The impact of glycemic variability on diabetic peripheral neuropathy
Mean glucose values alone cannot explain the patterns of morbidity and mortality due to dysglycemia in diabetes. Development of continuous glucose monitoring systems has improved the analysis and interpretation of glycemic variability. The roles of glycemic components other than constant hyperglycem...
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| Veröffentlicht in: | Endocrine 2016-09, Vol.53 (3), p.643-648 |
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| container_title | Endocrine |
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| creator | Jin, Heung Yong Lee, Kyung Ae Park, Tae Sun |
| description | Mean glucose values alone cannot explain the patterns of morbidity and mortality due to dysglycemia in diabetes. Development of continuous glucose monitoring systems has improved the analysis and interpretation of glycemic variability. The roles of glycemic components other than constant hyperglycemia in diabetic complications must be investigated because large clinical studies have indicated that risk factors besides the average glucose value of HbA1c are involved in chronic macrocomplications/microcomplications of diabetes. Among these complications, the pathogenesis of diabetic peripheral neuropathy is particularly complex, and several factors related to glucose and nonglucose pathways have been suggested as risk factors. There is little information regarding the effect of glycemic variability on diabetic peripheral neuropathy, unlike other microvascular complications of retinopathy and nephropathy, and whether glycemic variability causes harmful effects is still a matter of debate. In this review, we discuss the relationships between glycemic variability and diabetic peripheral neuropathy, focusing on somatosensory peripheral neuropathies rather than autonomic neuropathies. |
| doi_str_mv | 10.1007/s12020-016-1005-7 |
| format | Article |
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Development of continuous glucose monitoring systems has improved the analysis and interpretation of glycemic variability. The roles of glycemic components other than constant hyperglycemia in diabetic complications must be investigated because large clinical studies have indicated that risk factors besides the average glucose value of HbA1c are involved in chronic macrocomplications/microcomplications of diabetes. Among these complications, the pathogenesis of diabetic peripheral neuropathy is particularly complex, and several factors related to glucose and nonglucose pathways have been suggested as risk factors. There is little information regarding the effect of glycemic variability on diabetic peripheral neuropathy, unlike other microvascular complications of retinopathy and nephropathy, and whether glycemic variability causes harmful effects is still a matter of debate. In this review, we discuss the relationships between glycemic variability and diabetic peripheral neuropathy, focusing on somatosensory peripheral neuropathies rather than autonomic neuropathies.</description><subject>Autonomic nervous system</subject><subject>Blood Glucose - analysis</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic Neuropathies - blood</subject><subject>Endocrinology</subject><subject>Glucose</subject><subject>Glucose monitoring</subject><subject>Health risk assessment</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvasculature</subject><subject>Mini Review</subject><subject>Morbidity</subject><subject>multidisciplinary</subject><subject>Nephropathy</subject><subject>Peripheral Nervous System Diseases - blood</subject><subject>Peripheral neuropathy</subject><subject>Retinopathy</subject><subject>Risk factors</subject><subject>Science</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtLxTAQhYMoPq7-ADdScOOmOpM0TbIU3yC4UXBXctOpt9KXSSvcf28uV0UEwVVyJl_OMHMYO0Q4RQB1FpADhxQwT6OWqdpguyiliRWAzXgXUqYA-nmH7YXwCsA5z9U22-FKaIEad9nl44KSuh2sG5O-Sl6apaO2dsm79bWd1009LpO-S8ooaIz1gXw9LMjbJulo8v1gx8Vyn21Vtgl08HnO2NP11ePFbXr_cHN3cX6fugzkmJIUc6wArCwroaR0VlltUTk0Ym4U5mUuHYkMbUXaUM7LDESuDc9QohVOzNjJ2nfw_dtEYSzaOjhqGttRP4UCtQRluDLqHyhqIYzJVujxL_S1n3wXB4mUBq0yDTJSuKac70PwVBWDr1vrlwVCsUqjWKdRxDRWWhYr56NP52neUvn942v9EeBrIMSn7oX8j9Z_un4AUR6Sxg</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Jin, Heung Yong</creator><creator>Lee, Kyung Ae</creator><creator>Park, Tae Sun</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160901</creationdate><title>The impact of glycemic variability on diabetic peripheral neuropathy</title><author>Jin, Heung Yong ; Lee, Kyung Ae ; Park, Tae Sun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-e53b1f00a5df3755ca7a8a17c193b9716d65ce341afe89e62d40368924151a3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Autonomic nervous system</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic Neuropathies - blood</topic><topic>Endocrinology</topic><topic>Glucose</topic><topic>Glucose monitoring</topic><topic>Health risk assessment</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microvasculature</topic><topic>Mini Review</topic><topic>Morbidity</topic><topic>multidisciplinary</topic><topic>Nephropathy</topic><topic>Peripheral Nervous System Diseases - blood</topic><topic>Peripheral neuropathy</topic><topic>Retinopathy</topic><topic>Risk factors</topic><topic>Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Heung Yong</creatorcontrib><creatorcontrib>Lee, Kyung Ae</creatorcontrib><creatorcontrib>Park, Tae Sun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Heung Yong</au><au>Lee, Kyung Ae</au><au>Park, Tae Sun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of glycemic variability on diabetic peripheral neuropathy</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>53</volume><issue>3</issue><spage>643</spage><epage>648</epage><pages>643-648</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Mean glucose values alone cannot explain the patterns of morbidity and mortality due to dysglycemia in diabetes. 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| subjects | Autonomic nervous system Blood Glucose - analysis Diabetes Diabetes mellitus Diabetic Neuropathies - blood Endocrinology Glucose Glucose monitoring Health risk assessment Humanities and Social Sciences Humans Hyperglycemia Internal Medicine Medicine Medicine & Public Health Microvasculature Mini Review Morbidity multidisciplinary Nephropathy Peripheral Nervous System Diseases - blood Peripheral neuropathy Retinopathy Risk factors Science |
| title | The impact of glycemic variability on diabetic peripheral neuropathy |
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