Relevance of BRAF and NRAS mutations in the primary tumor and metastases of papillary thyroid carcinomas

Background Multifocality of papillary thyroid carcinoma (PTC) is common. BRAF and NRAS mutations are the most frequent genetic alterations in PTC. The purpose of this study was to determine the distribution and relevance of BRAFT1799A and NRAS mutations in PTC. Methods BRAFT1799A and NRAS mutations...

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Veröffentlicht in:	Head & neck 2016-12, Vol.38 (12), p.1772-1779
Hauptverfasser:	Cañadas-Garre, Marisa, Becerra-Massare, Patricia, Moreno Casares, Antonia, Calleja-Hernández, Miguel Ángel, Llamas-Elvira, José Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over BRAF Carcinoma, Papillary - genetics Carcinoma, Papillary - pathology Cohort Studies Female GTP Phosphohydrolases - genetics Humans Male Membrane Proteins - genetics metastases Middle Aged multifocality Mutation Neoplasm Invasiveness - pathology Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Neoplasm Recurrence, Local - pathology Neoplasm Staging NRAS papillary thyroid carcinoma Prognosis Proto-Oncogene Proteins B-raf - genetics Retrospective Studies Thyroid Cancer, Papillary Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology
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