Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage

Problem We aimed to investigate the modulatory effects of vitamin D on peripheral blood cellular immune response in patients with recurrent miscarriage (RM). Method of study The effect of vitamin D on the number of peripheral blood cells, T helper 1 (Th1) cytokines, and NK cytotoxicity was measured...

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Veröffentlicht in:	American journal of reproductive immunology (1989) 2016-12, Vol.76 (6), p.432-438
Hauptverfasser:	Chen, Xian, Yin, Biao, Lian, Ruo-Chun, Zhang, Tao, Zhang, Hong-Zhan, Diao, Liang-Hui, Li, Yu-Ye, Huang, Chun-Yu, Liang, De-Sheng, Zeng, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	1, 25‐dihydroxyvitamin D 25-dihydroxyvitamin D Abortion, Habitual - diet therapy Abortion, Habitual - genetics Abortion, Habitual - immunology Abortion, Habitual - pathology Administration, Oral Adult B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - pathology Calcitriol - administration & dosage Case-Control Studies Cytotoxicity Cytotoxicity, Immunologic Female Gene Expression Humans Immunologic Factors - administration & dosage Immunophenotyping Interferon-gamma - genetics Interferon-gamma - immunology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - pathology NK cytotoxicity peripheral blood lymphocyte Pregnancy recurrent miscarriage Th1 Cells - drug effects Th1 Cells - immunology Th1 Cells - pathology Th1 cytokines Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Vitamin D Vitamin D Deficiency - diet therapy Vitamin D Deficiency - genetics Vitamin D Deficiency - immunology Vitamin D Deficiency - pathology Vitamin deficiency
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Zusammenfassung:	Problem We aimed to investigate the modulatory effects of vitamin D on peripheral blood cellular immune response in patients with recurrent miscarriage (RM). Method of study The effect of vitamin D on the number of peripheral blood cells, T helper 1 (Th1) cytokines, and NK cytotoxicity was measured in 99 women with RM. Results The percentage of CD19+ B cells and NK cytotoxicity at an effector‐to‐target cell (E:T) ratio of 50:1, 25:1, and 12.5:1 were significantly higher in the vitamin D insufficiency group (VDI) than in the vitamin D normal group (VDN) (P
ISSN:	1046-7408 1600-0897
DOI:	10.1111/aji.12585