Activation of Peripheral κ-Opioid Receptors Normalizes Caffeine Effects Modified in Nicotine-Dependent Rats during Nicotine Withdrawal

The study examined the effect of peripheral (intragastric) ICI-204,448, an agonist of gastric κ-opioid receptors, on the psychostimulating and anxiolytic effects of caffeine in nicotinedependent rats at the stage of nicotine withdrawal. In these rats, the effects of caffeine (10 mg/kg) were perverte...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2016-10, Vol.161 (6), p.743-745
Hauptverfasser:	Sudakov, S. K., Bogdanova, N. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Behavior, Animal - drug effects Behavior, Animal - physiology Biomedical and Life Sciences Biomedicine Caffeine - pharmacology Cell Biology Central Nervous System Stimulants - pharmacology Gastric Absorption - physiology Internal Medicine Laboratory Medicine Male Maze Learning - drug effects Motor Activity - drug effects Motor Activity - physiology Nicotine - antagonists & inhibitors Nicotine - pharmacology Pathology Physiology Pyrrolidines - pharmacology Rats Rats, Wistar Receptors, Opioid, kappa - agonists Receptors, Opioid, kappa - metabolism Stomach - metabolism Substance Withdrawal Syndrome - drug therapy Substance Withdrawal Syndrome - metabolism Substance Withdrawal Syndrome - physiopathology Tobacco Use Disorder - drug therapy Tobacco Use Disorder - metabolism Tobacco Use Disorder - physiopathology
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