In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)
Aniba riparia(Lauraceae) is an important medicinal plant found in the Amazon region and presents alkaloids of the type alkamide known as riparins. Riparin A is structurally represented as the fundamental core of all Amazon riparins. This work aimed to assess the in vitro antioxidant, antitumor and a...
Gespeichert in:
| Veröffentlicht in: | Acta amazonica 2016-09, Vol.46 (3) |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | por |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | |
| container_title | Acta amazonica |
| container_volume | 46 |
| creator | de Araujo, Everton Jose Ferreira Lima, Layana Karine Farias Silva, Oskar Almeida Rezende Junior, Luis Mario Gutierrez, Stanley Juan Chavez Carvalho, Fernando Aecio de Amorim Lima, Francisco das Chagas Alves Pessoa, Claudia de Freitas, Rivelilson Mendes Ferreira, Paulo Michel Pinheiro |
| description | Aniba riparia(Lauraceae) is an important medicinal plant found in the Amazon region and presents alkaloids of the type alkamide known as riparins. Riparin A is structurally represented as the fundamental core of all Amazon riparins. This work aimed to assess the in vitro antioxidant, antitumor and antileishmanial effects of riparin A. Riparin A presented weak antioxidant capacity by tecniques of DPPH[middot] (EC50 of 296.2 [mu]g mL super(-1)) and ABTS[middot]+ (EC50 of 450.1 [mu]g mL super(-1)), showed moderate activity against colon carcinoma (HCT-116: IC50 of 21.7 [mu]g mL super(-1)) and leishmanicidal activity on promastigotes of L. amazonensis(IC sub(50) of 307.0 + or - 79.6, 193.7 + or - 44.3 and 81.8 + or - 11.2 [mu]g mL super(-1), respectively, after 24, 48 and 72 h of incubation). Then, in addition to its structural simplicity, riparin A revealed promising biological activities and remarkable in vitro leishmanicidal action, an important result in epidemiological point of view to control leishmaniasis in Brazil, including in the Amazon region.Original Abstract: Aniba riparia(Lauraceae) e uma importante planta medicinal encontrada na regiao amazonica que apresenta alcaloides do tipo alcamida e conhecidos como riparinas. Este trabalho teve como objetivo avaliar os efeitos antioxidantes, antitumorais e leishmanicidas in vitro da riparina A. Riparina A apresentou fraca capacidade antioxidante pelas tecnicas do DPPH[middot] (CE50 de 296,2 [mu]g mL super(-1)) e ABTS[middot]+ (CE50 de 450,1 [mu]g mL super(-1)), mostrou moderada atividade contra carcinoma de colon (HCT-116: CI50 de 21,7 [mu]g mL super(-1)) e atividade leishmanicida sobre formas promastigotas de Leishmania amazonensis(CI sub(50) de 307,0 + or - 79,6; 193,7 + or - 44,3 e 81,8 + or - 11,2 [mu]g mL super(-1), respectivamente, apos 24, 48 e 72 h de incubacao). Assim, alem de sua simplicidade estrutural, a riparina A revelou atividades biologicas promissoras e significativa acao leishmanicida in vitro, resultado importante diante da relevancia epidemiologica para controle da leishmaniose no Brasil, inclusive na regiao amazonica. |
| doi_str_mv | 10.1590/1809-4392201505436 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_1850782676</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1850782676</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_18507826763</originalsourceid><addsrcrecordid>eNqVi8tKxEAQRRtRMD5-wFUtRzBaSTqv5SCKgkv3Q5l0nNJ-jN0dUT_Br7ZHBvdCwa17qo4QZwVeFnWPV0WHfS6rviyxqLGWVbMnsj-4LzJEKfO6b9pDcRTCC2IlsZSZ-L638M7ROyAb2X3wmPLit8TZOJ-2EbTisDZkeUhnDTRETs4nuAk8b8izheXWSUPaPW95XCtYGvpyCepXMjyqAJN3BpaWn2jnESweaPY0KFLnJ-JgIh3U6S6PxeL25vH6Lt949zarEFeGw6C0JqvcHFZFV2PblU3bVP94_QFF3V5N</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1850782676</pqid></control><display><type>article</type><title>In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>de Araujo, Everton Jose Ferreira ; Lima, Layana Karine Farias ; Silva, Oskar Almeida ; Rezende Junior, Luis Mario ; Gutierrez, Stanley Juan Chavez ; Carvalho, Fernando Aecio de Amorim ; Lima, Francisco das Chagas Alves ; Pessoa, Claudia ; de Freitas, Rivelilson Mendes ; Ferreira, Paulo Michel Pinheiro</creator><creatorcontrib>de Araujo, Everton Jose Ferreira ; Lima, Layana Karine Farias ; Silva, Oskar Almeida ; Rezende Junior, Luis Mario ; Gutierrez, Stanley Juan Chavez ; Carvalho, Fernando Aecio de Amorim ; Lima, Francisco das Chagas Alves ; Pessoa, Claudia ; de Freitas, Rivelilson Mendes ; Ferreira, Paulo Michel Pinheiro</creatorcontrib><description>Aniba riparia(Lauraceae) is an important medicinal plant found in the Amazon region and presents alkaloids of the type alkamide known as riparins. Riparin A is structurally represented as the fundamental core of all Amazon riparins. This work aimed to assess the in vitro antioxidant, antitumor and antileishmanial effects of riparin A. Riparin A presented weak antioxidant capacity by tecniques of DPPH[middot] (EC50 of 296.2 [mu]g mL super(-1)) and ABTS[middot]+ (EC50 of 450.1 [mu]g mL super(-1)), showed moderate activity against colon carcinoma (HCT-116: IC50 of 21.7 [mu]g mL super(-1)) and leishmanicidal activity on promastigotes of L. amazonensis(IC sub(50) of 307.0 + or - 79.6, 193.7 + or - 44.3 and 81.8 + or - 11.2 [mu]g mL super(-1), respectively, after 24, 48 and 72 h of incubation). Then, in addition to its structural simplicity, riparin A revealed promising biological activities and remarkable in vitro leishmanicidal action, an important result in epidemiological point of view to control leishmaniasis in Brazil, including in the Amazon region.Original Abstract: Aniba riparia(Lauraceae) e uma importante planta medicinal encontrada na regiao amazonica que apresenta alcaloides do tipo alcamida e conhecidos como riparinas. Este trabalho teve como objetivo avaliar os efeitos antioxidantes, antitumorais e leishmanicidas in vitro da riparina A. Riparina A apresentou fraca capacidade antioxidante pelas tecnicas do DPPH[middot] (CE50 de 296,2 [mu]g mL super(-1)) e ABTS[middot]+ (CE50 de 450,1 [mu]g mL super(-1)), mostrou moderada atividade contra carcinoma de colon (HCT-116: CI50 de 21,7 [mu]g mL super(-1)) e atividade leishmanicida sobre formas promastigotas de Leishmania amazonensis(CI sub(50) de 307,0 + or - 79,6; 193,7 + or - 44,3 e 81,8 + or - 11,2 [mu]g mL super(-1), respectivamente, apos 24, 48 e 72 h de incubacao). Assim, alem de sua simplicidade estrutural, a riparina A revelou atividades biologicas promissoras e significativa acao leishmanicida in vitro, resultado importante diante da relevancia epidemiologica para controle da leishmaniose no Brasil, inclusive na regiao amazonica.</description><identifier>ISSN: 0044-5967</identifier><identifier>EISSN: 1809-4392</identifier><identifier>DOI: 10.1590/1809-4392201505436</identifier><language>por</language><subject>Aniba ; Lauraceae</subject><ispartof>Acta amazonica, 2016-09, Vol.46 (3)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>de Araujo, Everton Jose Ferreira</creatorcontrib><creatorcontrib>Lima, Layana Karine Farias</creatorcontrib><creatorcontrib>Silva, Oskar Almeida</creatorcontrib><creatorcontrib>Rezende Junior, Luis Mario</creatorcontrib><creatorcontrib>Gutierrez, Stanley Juan Chavez</creatorcontrib><creatorcontrib>Carvalho, Fernando Aecio de Amorim</creatorcontrib><creatorcontrib>Lima, Francisco das Chagas Alves</creatorcontrib><creatorcontrib>Pessoa, Claudia</creatorcontrib><creatorcontrib>de Freitas, Rivelilson Mendes</creatorcontrib><creatorcontrib>Ferreira, Paulo Michel Pinheiro</creatorcontrib><title>In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)</title><title>Acta amazonica</title><description>Aniba riparia(Lauraceae) is an important medicinal plant found in the Amazon region and presents alkaloids of the type alkamide known as riparins. Riparin A is structurally represented as the fundamental core of all Amazon riparins. This work aimed to assess the in vitro antioxidant, antitumor and antileishmanial effects of riparin A. Riparin A presented weak antioxidant capacity by tecniques of DPPH[middot] (EC50 of 296.2 [mu]g mL super(-1)) and ABTS[middot]+ (EC50 of 450.1 [mu]g mL super(-1)), showed moderate activity against colon carcinoma (HCT-116: IC50 of 21.7 [mu]g mL super(-1)) and leishmanicidal activity on promastigotes of L. amazonensis(IC sub(50) of 307.0 + or - 79.6, 193.7 + or - 44.3 and 81.8 + or - 11.2 [mu]g mL super(-1), respectively, after 24, 48 and 72 h of incubation). Then, in addition to its structural simplicity, riparin A revealed promising biological activities and remarkable in vitro leishmanicidal action, an important result in epidemiological point of view to control leishmaniasis in Brazil, including in the Amazon region.Original Abstract: Aniba riparia(Lauraceae) e uma importante planta medicinal encontrada na regiao amazonica que apresenta alcaloides do tipo alcamida e conhecidos como riparinas. Este trabalho teve como objetivo avaliar os efeitos antioxidantes, antitumorais e leishmanicidas in vitro da riparina A. Riparina A apresentou fraca capacidade antioxidante pelas tecnicas do DPPH[middot] (CE50 de 296,2 [mu]g mL super(-1)) e ABTS[middot]+ (CE50 de 450,1 [mu]g mL super(-1)), mostrou moderada atividade contra carcinoma de colon (HCT-116: CI50 de 21,7 [mu]g mL super(-1)) e atividade leishmanicida sobre formas promastigotas de Leishmania amazonensis(CI sub(50) de 307,0 + or - 79,6; 193,7 + or - 44,3 e 81,8 + or - 11,2 [mu]g mL super(-1), respectivamente, apos 24, 48 e 72 h de incubacao). Assim, alem de sua simplicidade estrutural, a riparina A revelou atividades biologicas promissoras e significativa acao leishmanicida in vitro, resultado importante diante da relevancia epidemiologica para controle da leishmaniose no Brasil, inclusive na regiao amazonica.</description><subject>Aniba</subject><subject>Lauraceae</subject><issn>0044-5967</issn><issn>1809-4392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqVi8tKxEAQRRtRMD5-wFUtRzBaSTqv5SCKgkv3Q5l0nNJ-jN0dUT_Br7ZHBvdCwa17qo4QZwVeFnWPV0WHfS6rviyxqLGWVbMnsj-4LzJEKfO6b9pDcRTCC2IlsZSZ-L638M7ROyAb2X3wmPLit8TZOJ-2EbTisDZkeUhnDTRETs4nuAk8b8izheXWSUPaPW95XCtYGvpyCepXMjyqAJN3BpaWn2jnESweaPY0KFLnJ-JgIh3U6S6PxeL25vH6Lt949zarEFeGw6C0JqvcHFZFV2PblU3bVP94_QFF3V5N</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>de Araujo, Everton Jose Ferreira</creator><creator>Lima, Layana Karine Farias</creator><creator>Silva, Oskar Almeida</creator><creator>Rezende Junior, Luis Mario</creator><creator>Gutierrez, Stanley Juan Chavez</creator><creator>Carvalho, Fernando Aecio de Amorim</creator><creator>Lima, Francisco das Chagas Alves</creator><creator>Pessoa, Claudia</creator><creator>de Freitas, Rivelilson Mendes</creator><creator>Ferreira, Paulo Michel Pinheiro</creator><scope>7ST</scope><scope>7UA</scope><scope>C1K</scope><scope>M7N</scope><scope>SOI</scope></search><sort><creationdate>20160901</creationdate><title>In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)</title><author>de Araujo, Everton Jose Ferreira ; Lima, Layana Karine Farias ; Silva, Oskar Almeida ; Rezende Junior, Luis Mario ; Gutierrez, Stanley Juan Chavez ; Carvalho, Fernando Aecio de Amorim ; Lima, Francisco das Chagas Alves ; Pessoa, Claudia ; de Freitas, Rivelilson Mendes ; Ferreira, Paulo Michel Pinheiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_18507826763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>por</language><creationdate>2016</creationdate><topic>Aniba</topic><topic>Lauraceae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Araujo, Everton Jose Ferreira</creatorcontrib><creatorcontrib>Lima, Layana Karine Farias</creatorcontrib><creatorcontrib>Silva, Oskar Almeida</creatorcontrib><creatorcontrib>Rezende Junior, Luis Mario</creatorcontrib><creatorcontrib>Gutierrez, Stanley Juan Chavez</creatorcontrib><creatorcontrib>Carvalho, Fernando Aecio de Amorim</creatorcontrib><creatorcontrib>Lima, Francisco das Chagas Alves</creatorcontrib><creatorcontrib>Pessoa, Claudia</creatorcontrib><creatorcontrib>de Freitas, Rivelilson Mendes</creatorcontrib><creatorcontrib>Ferreira, Paulo Michel Pinheiro</creatorcontrib><collection>Environment Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Environment Abstracts</collection><jtitle>Acta amazonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Araujo, Everton Jose Ferreira</au><au>Lima, Layana Karine Farias</au><au>Silva, Oskar Almeida</au><au>Rezende Junior, Luis Mario</au><au>Gutierrez, Stanley Juan Chavez</au><au>Carvalho, Fernando Aecio de Amorim</au><au>Lima, Francisco das Chagas Alves</au><au>Pessoa, Claudia</au><au>de Freitas, Rivelilson Mendes</au><au>Ferreira, Paulo Michel Pinheiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)</atitle><jtitle>Acta amazonica</jtitle><date>2016-09-01</date><risdate>2016</risdate><volume>46</volume><issue>3</issue><issn>0044-5967</issn><eissn>1809-4392</eissn><abstract>Aniba riparia(Lauraceae) is an important medicinal plant found in the Amazon region and presents alkaloids of the type alkamide known as riparins. Riparin A is structurally represented as the fundamental core of all Amazon riparins. This work aimed to assess the in vitro antioxidant, antitumor and antileishmanial effects of riparin A. Riparin A presented weak antioxidant capacity by tecniques of DPPH[middot] (EC50 of 296.2 [mu]g mL super(-1)) and ABTS[middot]+ (EC50 of 450.1 [mu]g mL super(-1)), showed moderate activity against colon carcinoma (HCT-116: IC50 of 21.7 [mu]g mL super(-1)) and leishmanicidal activity on promastigotes of L. amazonensis(IC sub(50) of 307.0 + or - 79.6, 193.7 + or - 44.3 and 81.8 + or - 11.2 [mu]g mL super(-1), respectively, after 24, 48 and 72 h of incubation). Then, in addition to its structural simplicity, riparin A revealed promising biological activities and remarkable in vitro leishmanicidal action, an important result in epidemiological point of view to control leishmaniasis in Brazil, including in the Amazon region.Original Abstract: Aniba riparia(Lauraceae) e uma importante planta medicinal encontrada na regiao amazonica que apresenta alcaloides do tipo alcamida e conhecidos como riparinas. Este trabalho teve como objetivo avaliar os efeitos antioxidantes, antitumorais e leishmanicidas in vitro da riparina A. Riparina A apresentou fraca capacidade antioxidante pelas tecnicas do DPPH[middot] (CE50 de 296,2 [mu]g mL super(-1)) e ABTS[middot]+ (CE50 de 450,1 [mu]g mL super(-1)), mostrou moderada atividade contra carcinoma de colon (HCT-116: CI50 de 21,7 [mu]g mL super(-1)) e atividade leishmanicida sobre formas promastigotas de Leishmania amazonensis(CI sub(50) de 307,0 + or - 79,6; 193,7 + or - 44,3 e 81,8 + or - 11,2 [mu]g mL super(-1), respectivamente, apos 24, 48 e 72 h de incubacao). Assim, alem de sua simplicidade estrutural, a riparina A revelou atividades biologicas promissoras e significativa acao leishmanicida in vitro, resultado importante diante da relevancia epidemiologica para controle da leishmaniose no Brasil, inclusive na regiao amazonica.</abstract><doi>10.1590/1809-4392201505436</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0044-5967 |
| ispartof | Acta amazonica, 2016-09, Vol.46 (3) |
| issn | 0044-5967 1809-4392 |
| language | por |
| recordid | cdi_proquest_miscellaneous_1850782676 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aniba Lauraceae |
| title | In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T12%3A37%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vitro%20antioxidant,%20antitumor%20and%20leishmanicidal%20activity%20of%20riparin%20A,%20an%20analog%20of%20the%20Amazon%20alkamides%20from%20Aniba%20riparia%20(Lauraceae)&rft.jtitle=Acta%20amazonica&rft.au=de%20Araujo,%20Everton%20Jose%20Ferreira&rft.date=2016-09-01&rft.volume=46&rft.issue=3&rft.issn=0044-5967&rft.eissn=1809-4392&rft_id=info:doi/10.1590/1809-4392201505436&rft_dat=%3Cproquest%3E1850782676%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1850782676&rft_id=info:pmid/&rfr_iscdi=true |