Inactivation of inflammasomes by pathogens regulates inflammation

Inflammatory response is initiated and sustained by the action of quintessential pro-inflammatory cytokines of immune system namely IL-1β and IL-18. The maturation process of those cytokines is ensured by caspase-1 enzymatic activity, that is in turn is tightly controlled by multiprotein complexes c...

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Veröffentlicht in:	Biochemistry (Moscow) 2016-11, Vol.81 (11), p.1326-1339
Hauptverfasser:	Garib, F. Yu, Rizopulu, A. P., Kuchmiy, A. A., Garib, V. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Caspase 1 - immunology Caspase-1 Cell death Cellular biology Coevolution Cytokines Damage patterns Enzymatic activity Humans IL-1β Immune clearance Immune response Immune system Inactivation Infectious diseases Inflammasomes Inflammasomes - immunology Inflammation Inflammation - immunology Inflammation - pathology Inflammatory response Innate immunity Interleukin 18 Interleukin-18 - immunology Interleukin-1beta - immunology Life Sciences Microbiology Pathogens Pyroptosis Review
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