HCV NS3 naturally occurring variants in HIV/HCV coinfected DAA-naïve patients: consideration for HCV genotyping resistance testing
Purpose Data on the frequency of HCV naturally occurring drug-resistant variants (RAVs) at baseline in HIV/HCV coinfected patients are scarce. Methods NS3-HCV RAVs were studied by full-population direct sequencing from plasma specimens of 345 DAA-naïve patients with HCV chronic hepatitis (159 of the...
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| Veröffentlicht in: | Infection 2016-12, Vol.44 (6), p.789-792 |
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| container_title | Infection |
| container_volume | 44 |
| creator | Ruggiero, T. Burdino, E. Calcagno, A. Bonora, S. Boglione, L. Di Perri, G. Ghisetti, V. |
| description | Purpose
Data on the frequency of HCV naturally occurring drug-resistant variants (RAVs) at baseline in HIV/HCV coinfected patients are scarce.
Methods
NS3-HCV RAVs were studied by full-population direct sequencing from plasma specimens of 345 DAA-naïve patients with HCV chronic hepatitis (159 of them with HIV/HCV-coinfection).
Results
NS3 RAVs were identified in 31.5 % of patients, with a significant proportion of HIV/HCV coinfected DAA-naïve patients compared to those with HCV monoinfection (38 vs. 25 %
p
= 0.0104, OR 1.84; 95 % CI 1.162–2.916).
Conclusions
HCV resistance genotyping test before treatment may be worth in special populations such as HIV/HCV coinfection to optimize patient treatment. |
| doi_str_mv | 10.1007/s15010-016-0937-4 |
| format | Article |
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Data on the frequency of HCV naturally occurring drug-resistant variants (RAVs) at baseline in HIV/HCV coinfected patients are scarce.
Methods
NS3-HCV RAVs were studied by full-population direct sequencing from plasma specimens of 345 DAA-naïve patients with HCV chronic hepatitis (159 of them with HIV/HCV-coinfection).
Results
NS3 RAVs were identified in 31.5 % of patients, with a significant proportion of HIV/HCV coinfected DAA-naïve patients compared to those with HCV monoinfection (38 vs. 25 %
p
= 0.0104, OR 1.84; 95 % CI 1.162–2.916).
Conclusions
HCV resistance genotyping test before treatment may be worth in special populations such as HIV/HCV coinfection to optimize patient treatment.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/s15010-016-0937-4</identifier><identifier>PMID: 27522673</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antiviral Agents ; Brief Report ; Cohort Studies ; Coinfection ; Family Medicine ; Female ; General Practice ; Genotype ; Hepacivirus - genetics ; Hepatitis C - complications ; Hepatitis C - virology ; Hepatitis C virus ; HIV Infections - complications ; Humans ; Infectious Diseases ; Internal Medicine ; Lentivirus ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Pneumoviridae ; Retroviridae ; Viral Nonstructural Proteins - genetics</subject><ispartof>Infection, 2016-12, Vol.44 (6), p.789-792</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Infection is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-944c1b92f2003eb516d175b8a5994a33797c439250b2fb11e48ecaecc8c5830a3</citedby><cites>FETCH-LOGICAL-c405t-944c1b92f2003eb516d175b8a5994a33797c439250b2fb11e48ecaecc8c5830a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s15010-016-0937-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s15010-016-0937-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27522673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruggiero, T.</creatorcontrib><creatorcontrib>Burdino, E.</creatorcontrib><creatorcontrib>Calcagno, A.</creatorcontrib><creatorcontrib>Bonora, S.</creatorcontrib><creatorcontrib>Boglione, L.</creatorcontrib><creatorcontrib>Di Perri, G.</creatorcontrib><creatorcontrib>Ghisetti, V.</creatorcontrib><title>HCV NS3 naturally occurring variants in HIV/HCV coinfected DAA-naïve patients: consideration for HCV genotyping resistance testing</title><title>Infection</title><addtitle>Infection</addtitle><addtitle>Infection</addtitle><description>Purpose
Data on the frequency of HCV naturally occurring drug-resistant variants (RAVs) at baseline in HIV/HCV coinfected patients are scarce.
Methods
NS3-HCV RAVs were studied by full-population direct sequencing from plasma specimens of 345 DAA-naïve patients with HCV chronic hepatitis (159 of them with HIV/HCV-coinfection).
Results
NS3 RAVs were identified in 31.5 % of patients, with a significant proportion of HIV/HCV coinfected DAA-naïve patients compared to those with HCV monoinfection (38 vs. 25 %
p
= 0.0104, OR 1.84; 95 % CI 1.162–2.916).
Conclusions
HCV resistance genotyping test before treatment may be worth in special populations such as HIV/HCV coinfection to optimize patient treatment.</description><subject>Antiviral Agents</subject><subject>Brief Report</subject><subject>Cohort Studies</subject><subject>Coinfection</subject><subject>Family Medicine</subject><subject>Female</subject><subject>General Practice</subject><subject>Genotype</subject><subject>Hepacivirus - genetics</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - virology</subject><subject>Hepatitis C virus</subject><subject>HIV Infections - complications</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Internal Medicine</subject><subject>Lentivirus</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Pneumoviridae</subject><subject>Retroviridae</subject><subject>Viral Nonstructural Proteins - genetics</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc9u1DAQhy0EokvhAbggS1y4hI7_xQ631RbYShUcgF4txzupXGWdYCeV9swD8RB9sTraghASEifL429-49FHyEsGbxmAPstMAYMKWF1BI3QlH5EVk6IpNy0ekxUIgMowXp-QZznfAIBqpH5KTrhWnNdarMiP7eaKfvoiaHTTnFzfH-jg_ZxSiNf01qXg4pRpiHR7cXW2sH4IsUM_4Y6er9dVdHc_b5GObgpYyHflPeaww1QKQ6TdkOjSdY1xmA7jEpowhzy56JFOmKdSek6edK7P-OLhPCXfPrz_utlWl58_XmzWl5WXoKaqkdKztuEdBxDYKlbvmFatcapppBNCN9qX5bmClnctYygNeofeG6-MACdOyZtj7piG73OZbfche-x7F3GYs2VGgTZQa_kfaJlUGy54QV__hd4Mc4plkYXihjfAWKHYkfJpyDlhZ8cU9i4dLAO7yLRHmbbItItMu3zi1UPy3O5x97vjl70C8COQx8UXpj9G_zP1HpOkqU8</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Ruggiero, T.</creator><creator>Burdino, E.</creator><creator>Calcagno, A.</creator><creator>Bonora, S.</creator><creator>Boglione, L.</creator><creator>Di Perri, G.</creator><creator>Ghisetti, V.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>7T5</scope></search><sort><creationdate>20161201</creationdate><title>HCV NS3 naturally occurring variants in HIV/HCV coinfected DAA-naïve patients: consideration for HCV genotyping resistance testing</title><author>Ruggiero, T. ; Burdino, E. ; Calcagno, A. ; Bonora, S. ; Boglione, L. ; Di Perri, G. ; Ghisetti, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-944c1b92f2003eb516d175b8a5994a33797c439250b2fb11e48ecaecc8c5830a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antiviral Agents</topic><topic>Brief Report</topic><topic>Cohort Studies</topic><topic>Coinfection</topic><topic>Family Medicine</topic><topic>Female</topic><topic>General Practice</topic><topic>Genotype</topic><topic>Hepacivirus - genetics</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - virology</topic><topic>Hepatitis C virus</topic><topic>HIV Infections - complications</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Internal Medicine</topic><topic>Lentivirus</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Pneumoviridae</topic><topic>Retroviridae</topic><topic>Viral Nonstructural Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruggiero, T.</creatorcontrib><creatorcontrib>Burdino, E.</creatorcontrib><creatorcontrib>Calcagno, A.</creatorcontrib><creatorcontrib>Bonora, S.</creatorcontrib><creatorcontrib>Boglione, L.</creatorcontrib><creatorcontrib>Di Perri, G.</creatorcontrib><creatorcontrib>Ghisetti, V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><jtitle>Infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruggiero, T.</au><au>Burdino, E.</au><au>Calcagno, A.</au><au>Bonora, S.</au><au>Boglione, L.</au><au>Di Perri, G.</au><au>Ghisetti, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HCV NS3 naturally occurring variants in HIV/HCV coinfected DAA-naïve patients: consideration for HCV genotyping resistance testing</atitle><jtitle>Infection</jtitle><stitle>Infection</stitle><addtitle>Infection</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>44</volume><issue>6</issue><spage>789</spage><epage>792</epage><pages>789-792</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><abstract>Purpose
Data on the frequency of HCV naturally occurring drug-resistant variants (RAVs) at baseline in HIV/HCV coinfected patients are scarce.
Methods
NS3-HCV RAVs were studied by full-population direct sequencing from plasma specimens of 345 DAA-naïve patients with HCV chronic hepatitis (159 of them with HIV/HCV-coinfection).
Results
NS3 RAVs were identified in 31.5 % of patients, with a significant proportion of HIV/HCV coinfected DAA-naïve patients compared to those with HCV monoinfection (38 vs. 25 %
p
= 0.0104, OR 1.84; 95 % CI 1.162–2.916).
Conclusions
HCV resistance genotyping test before treatment may be worth in special populations such as HIV/HCV coinfection to optimize patient treatment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27522673</pmid><doi>10.1007/s15010-016-0937-4</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8126 |
| ispartof | Infection, 2016-12, Vol.44 (6), p.789-792 |
| issn | 0300-8126 1439-0973 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1850780674 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Antiviral Agents Brief Report Cohort Studies Coinfection Family Medicine Female General Practice Genotype Hepacivirus - genetics Hepatitis C - complications Hepatitis C - virology Hepatitis C virus HIV Infections - complications Humans Infectious Diseases Internal Medicine Lentivirus Male Medicine Medicine & Public Health Middle Aged Pneumoviridae Retroviridae Viral Nonstructural Proteins - genetics |
| title | HCV NS3 naturally occurring variants in HIV/HCV coinfected DAA-naïve patients: consideration for HCV genotyping resistance testing |
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