Protective effect of betulin on cognitive decline in streptozotocin (STZ)-induced diabetic rats

•Betulin inhibited NF-kB in STZ-induced rats.•Betulin increased HO-1and Nrf-2 in STZ-induced rats.•Betulin improved cognitive impairments induced by STZ in rats. Betulin is extracted from birch tree bark and exerts diverse pharmacological activities. The present study was designed to investigate the...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2016-12, Vol.57, p.104-111
Hauptverfasser:	Ma, Chunhua, Long, Hongyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bark Betulin Chemical compounds Cognitive ability Cognitive decline Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology Cognitive Dysfunction - pathology Cytokines Cytokines - metabolism Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - complications Disease Models, Animal Dose-Response Relationship, Drug Experiments GA-binding protein Glucose Glucose tolerance Glucose Tolerance Test Heme Heme oxygenase (decyclizing) Heme Oxygenase-1 - metabolism Hippocampus Hippocampus - drug effects Hippocampus - metabolism HO-1/Nrf-2/NF-κB Inflammation Insulin Interleukin 6 Intolerance Learning Male Malondialdehyde Malondialdehyde - blood Maze Learning - drug effects Memory NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism Oxygenase Pharmacology Rats Rats, Sprague-Dawley Streptozocin STZ Superoxide dismutase Superoxide Dismutase - blood Triterpenes - therapeutic use Tumor necrosis factor-α Up-Regulation - drug effects
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