Microscale mechanical and mineral heterogeneity of human cortical bone governs osteoclast activity

Abstract Human cortical bone permanently remodels itself resulting in a haversian microstructure with heterogeneous mechanical and mineral properties. Remodeling is carried out by a subtle equilibrium between bone formation by osteoblasts and bone degradation by osteoclasts. The mechanisms regulatin...

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Veröffentlicht in:Bone (New York, N.Y.) N.Y.), 2017-01, Vol.94, p.42-49
Hauptverfasser: Pernelle, K, Imbert, L, Bosser, C, Auregan, J-C, Cruel, M, Ogier, A, Jurdic, P, Hoc, T
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container_end_page 49
container_issue
container_start_page 42
container_title Bone (New York, N.Y.)
container_volume 94
creator Pernelle, K
Imbert, L
Bosser, C
Auregan, J-C
Cruel, M
Ogier, A
Jurdic, P
Hoc, T
description Abstract Human cortical bone permanently remodels itself resulting in a haversian microstructure with heterogeneous mechanical and mineral properties. Remodeling is carried out by a subtle equilibrium between bone formation by osteoblasts and bone degradation by osteoclasts. The mechanisms regulating osteoclast activity were studied using easy access supports whose homogeneous microstructures differ from human bone microstructure. In the current study, we show that human osteoclasts resorb human cortical bone non-randomly with respect to this specific human bone microstructural heterogeneity. The characterization of this new resorption profile demonstrates that osteoclasts preferentially resorb particular osteons that have weak mechanical properties and mineral contents and that contain small hydroxyapatite crystals with a high carbonate content. Therefore, the influence of human bone microstructure heterogeneity on osteoclast activity could be a key parameter for osteoclast behaviour, for both in vitro and clinical studies.
doi_str_mv 10.1016/j.bone.2016.10.002
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Adult
Aged
Animals
Biomechanical Phenomena
Biomechanics
Bone Resorption - pathology
Cattle
Cortical Bone - physiology
Humans
Male
Matrix mineralization
Minerals - metabolism
Nano indentation
Orthopedics
Osteoclasts
Osteoclasts - metabolism
Raman spectroscopy
title Microscale mechanical and mineral heterogeneity of human cortical bone governs osteoclast activity
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