Ezetimibe increases intestinal expression of the LDL receptor gene in dyslipidaemic men with insulin resistance

Aim To gain further insight into intestinal cholesterol homeostasis in dyslipidaemic men with insulin resistance (IR) by examining the impact of treatment with ezetimibe on the expression of key genes involved in cholesterol synthesis and LDL receptor (R)‐mediated uptake of lipoproteins. Methods A t...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2016-12, Vol.18 (12), p.1226-1235
Hauptverfasser:	Drouin-Chartier, Jean-Philippe, Tremblay, André J., Lemelin, Valéry, Lépine, Marie-Claude, Lamarche, Benoît, Couture, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticholesteremic Agents - therapeutic use Blood Glucose - metabolism Cholesterol Cholesterol - blood cholesterol absorption Cross-Over Studies Double-Blind Method Duodenum - metabolism Dyslipidemia Dyslipidemias - drug therapy Dyslipidemias - metabolism Endoscopy, Digestive System ezetimibe Ezetimibe - therapeutic use Gene Expression Humans Hydroxymethylglutaryl CoA Reductases - genetics Insulin - metabolism Insulin Resistance LDL receptor Male Metabolic disorders Middle Aged Proprotein Convertase 9 - genetics Real-Time Polymerase Chain Reaction Receptors, LDL - genetics RNA, Messenger - metabolism Sterol O-Acyltransferase - genetics Sterol O-Acyltransferase 2 Sterol Regulatory Element Binding Protein 2 - genetics Triglycerides - metabolism
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