Extended exposure to sugar and/or caffeine produces distinct behavioral and neurochemical profiles in the orbitofrontal cortex of rats: Implications for neural function
Caffeine is a psychostimulant commonly consumed with high levels of sugar. The increased availability of highly caffeinated, high sugar energy drinks could put some consumers at risk of being exposed to high doses of caffeine and sugar. Notably, research that has examined the consequences of this co...
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| Veröffentlicht in: | Proteomics (Weinheim) 2016-11, Vol.16 (22), p.2894-2910 |
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| creator | Franklin, Jane L. Mirzaei, Mehdi Wearne, Travis A. Homewood, Judi Goodchild, Ann K. Haynes, Paul A. Cornish, Jennifer L. |
| description | Caffeine is a psychostimulant commonly consumed with high levels of sugar. The increased availability of highly caffeinated, high sugar energy drinks could put some consumers at risk of being exposed to high doses of caffeine and sugar. Notably, research that has examined the consequences of this combination is limited. Here, we explored the effect of chronic exposure to caffeine and/or sugar on behavior and protein levels in the orbitofrontal cortex (OFC) of rats. The OFC brain region has been implicated in neuropsychiatric conditions, including obesity and addiction behaviors. Adult male Sprague–Dawley rats were treated for 26 days with control, caffeine (0.6 g/L), 10% sugar, or combination of both. Locomotor behavior was measured on the first and last day of treatment, then 1 week after treatment. Two hours following final behavioral testing, brains were rapidly removed and prepared for proteomic analysis of the OFC. Label‐free quantitative shotgun analysis revealed that 21, 12, and 23% of proteins identified in the OFC were differentially expressed by sugar and/or caffeine. The results demonstrate that the intake of high levels of sugar and/or low to moderate levels of caffeine has different behavioral consequences. Moreover, each treatment results in a unique proteomic profile with different implications for neural health. |
| doi_str_mv | 10.1002/pmic.201600032 |
| format | Article |
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The increased availability of highly caffeinated, high sugar energy drinks could put some consumers at risk of being exposed to high doses of caffeine and sugar. Notably, research that has examined the consequences of this combination is limited. Here, we explored the effect of chronic exposure to caffeine and/or sugar on behavior and protein levels in the orbitofrontal cortex (OFC) of rats. The OFC brain region has been implicated in neuropsychiatric conditions, including obesity and addiction behaviors. Adult male Sprague–Dawley rats were treated for 26 days with control, caffeine (0.6 g/L), 10% sugar, or combination of both. Locomotor behavior was measured on the first and last day of treatment, then 1 week after treatment. Two hours following final behavioral testing, brains were rapidly removed and prepared for proteomic analysis of the OFC. Label‐free quantitative shotgun analysis revealed that 21, 12, and 23% of proteins identified in the OFC were differentially expressed by sugar and/or caffeine. The results demonstrate that the intake of high levels of sugar and/or low to moderate levels of caffeine has different behavioral consequences. Moreover, each treatment results in a unique proteomic profile with different implications for neural health.</description><identifier>ISSN: 1615-9853</identifier><identifier>EISSN: 1615-9861</identifier><identifier>DOI: 10.1002/pmic.201600032</identifier><identifier>PMID: 27588558</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Addictions ; Animal proteomics ; Animals ; Behavior ; Behavior, Animal - drug effects ; Beverages ; Beverages - adverse effects ; Brain ; Caffeine ; Caffeine - adverse effects ; Caffeine - pharmacology ; Central Nervous System Stimulants - adverse effects ; Central Nervous System Stimulants - pharmacology ; Chronic exposure ; Dietary Carbohydrates - adverse effects ; Dietary Carbohydrates - pharmacology ; Exposure ; Hyperactivity ; Locomotion - drug effects ; Male ; Neurological disease ; Orbitofrontal cortex ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - physiology ; Proteins ; Proteome - analysis ; Proteome - metabolism ; Proteomics ; Rats ; Rats, Sprague-Dawley ; Signal Transduction - drug effects ; Sugar ; Weight Gain - drug effects</subject><ispartof>Proteomics (Weinheim), 2016-11, Vol.16 (22), p.2894-2910</ispartof><rights>2016 WILEY‐VCH Verlag GmbH & Co. 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KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4404-6abc14b61f675476870fe7870121979804d4c428128a87c707989de73ca28d393</citedby><cites>FETCH-LOGICAL-c4404-6abc14b61f675476870fe7870121979804d4c428128a87c707989de73ca28d393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpmic.201600032$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpmic.201600032$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27588558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Franklin, Jane L.</creatorcontrib><creatorcontrib>Mirzaei, Mehdi</creatorcontrib><creatorcontrib>Wearne, Travis A.</creatorcontrib><creatorcontrib>Homewood, Judi</creatorcontrib><creatorcontrib>Goodchild, Ann K.</creatorcontrib><creatorcontrib>Haynes, Paul A.</creatorcontrib><creatorcontrib>Cornish, Jennifer L.</creatorcontrib><title>Extended exposure to sugar and/or caffeine produces distinct behavioral and neurochemical profiles in the orbitofrontal cortex of rats: Implications for neural function</title><title>Proteomics (Weinheim)</title><addtitle>Proteomics</addtitle><description>Caffeine is a psychostimulant commonly consumed with high levels of sugar. The increased availability of highly caffeinated, high sugar energy drinks could put some consumers at risk of being exposed to high doses of caffeine and sugar. Notably, research that has examined the consequences of this combination is limited. Here, we explored the effect of chronic exposure to caffeine and/or sugar on behavior and protein levels in the orbitofrontal cortex (OFC) of rats. The OFC brain region has been implicated in neuropsychiatric conditions, including obesity and addiction behaviors. Adult male Sprague–Dawley rats were treated for 26 days with control, caffeine (0.6 g/L), 10% sugar, or combination of both. Locomotor behavior was measured on the first and last day of treatment, then 1 week after treatment. Two hours following final behavioral testing, brains were rapidly removed and prepared for proteomic analysis of the OFC. Label‐free quantitative shotgun analysis revealed that 21, 12, and 23% of proteins identified in the OFC were differentially expressed by sugar and/or caffeine. The results demonstrate that the intake of high levels of sugar and/or low to moderate levels of caffeine has different behavioral consequences. Moreover, each treatment results in a unique proteomic profile with different implications for neural health.</description><subject>Addictions</subject><subject>Animal proteomics</subject><subject>Animals</subject><subject>Behavior</subject><subject>Behavior, Animal - drug effects</subject><subject>Beverages</subject><subject>Beverages - adverse effects</subject><subject>Brain</subject><subject>Caffeine</subject><subject>Caffeine - adverse effects</subject><subject>Caffeine - pharmacology</subject><subject>Central Nervous System Stimulants - adverse effects</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Chronic exposure</subject><subject>Dietary Carbohydrates - adverse effects</subject><subject>Dietary Carbohydrates - pharmacology</subject><subject>Exposure</subject><subject>Hyperactivity</subject><subject>Locomotion - drug effects</subject><subject>Male</subject><subject>Neurological disease</subject><subject>Orbitofrontal cortex</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - physiology</subject><subject>Proteins</subject><subject>Proteome - analysis</subject><subject>Proteome - metabolism</subject><subject>Proteomics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Signal Transduction - drug effects</subject><subject>Sugar</subject><subject>Weight Gain - drug effects</subject><issn>1615-9853</issn><issn>1615-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkT-P1DAQxSME4v5AS4ks0dBkz3bs2KFDq2NvYQ8oQEg0luOMWR_ZONgOt_eN-Jg42mMLGmhsa_x7b2b0iuIZwQuCMb0Yd84sKCY1xriiD4pTUhNeNrImD49vXp0UZzHeYEyEbMTj4oQKLiXn8rT4dblPMHTQIdiPPk4BUPIoTt90QHroLnxARlsLbgA0Bt9NBiLqXExuMAm1sNU_nQ-6n2E0wBS82UKeKVcybl2fcTegtAXkQ-uSt8EPKf8aHxLskbco6BRfofVu7LMsOT9EZHPb2SxzdsqNcvFJ8cjqPsLT-_u8-Pzm8tPyqtx8WK2XrzelYQyzstatIaytia0FZ6KWAlsQ-SSUNKKRmHXMMCoJlVoKI3CuNR2Iymgqu6qpzouXB988_o8JYlI7Fw30vR7AT1ERybEQnJP_QSvOcFNzmtEXf6E3fgpDXkRRXPGaCy5manGgTPAxBrBqDG6nw50iWM1xqzludYw7C57f207tDroj_iffDPADcJuTuPuHnfp4vV4SyhqWdeVBl5OG_VGnw3dVi0pw9eX9Sr39evVuJa-x2lS_Ae38xys</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Franklin, Jane L.</creator><creator>Mirzaei, Mehdi</creator><creator>Wearne, Travis A.</creator><creator>Homewood, Judi</creator><creator>Goodchild, Ann K.</creator><creator>Haynes, Paul A.</creator><creator>Cornish, Jennifer L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201611</creationdate><title>Extended exposure to sugar and/or caffeine produces distinct behavioral and neurochemical profiles in the orbitofrontal cortex of rats: Implications for neural function</title><author>Franklin, Jane L. ; Mirzaei, Mehdi ; Wearne, Travis A. ; Homewood, Judi ; Goodchild, Ann K. ; Haynes, Paul A. ; Cornish, Jennifer L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4404-6abc14b61f675476870fe7870121979804d4c428128a87c707989de73ca28d393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Addictions</topic><topic>Animal proteomics</topic><topic>Animals</topic><topic>Behavior</topic><topic>Behavior, Animal - drug effects</topic><topic>Beverages</topic><topic>Beverages - adverse effects</topic><topic>Brain</topic><topic>Caffeine</topic><topic>Caffeine - adverse effects</topic><topic>Caffeine - pharmacology</topic><topic>Central Nervous System Stimulants - adverse effects</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Chronic exposure</topic><topic>Dietary Carbohydrates - adverse effects</topic><topic>Dietary Carbohydrates - pharmacology</topic><topic>Exposure</topic><topic>Hyperactivity</topic><topic>Locomotion - drug effects</topic><topic>Male</topic><topic>Neurological disease</topic><topic>Orbitofrontal cortex</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - physiology</topic><topic>Proteins</topic><topic>Proteome - analysis</topic><topic>Proteome - metabolism</topic><topic>Proteomics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Signal Transduction - drug effects</topic><topic>Sugar</topic><topic>Weight Gain - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franklin, Jane L.</creatorcontrib><creatorcontrib>Mirzaei, Mehdi</creatorcontrib><creatorcontrib>Wearne, Travis A.</creatorcontrib><creatorcontrib>Homewood, Judi</creatorcontrib><creatorcontrib>Goodchild, Ann K.</creatorcontrib><creatorcontrib>Haynes, Paul A.</creatorcontrib><creatorcontrib>Cornish, Jennifer L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Proteomics (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franklin, Jane L.</au><au>Mirzaei, Mehdi</au><au>Wearne, Travis A.</au><au>Homewood, Judi</au><au>Goodchild, Ann K.</au><au>Haynes, Paul A.</au><au>Cornish, Jennifer L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extended exposure to sugar and/or caffeine produces distinct behavioral and neurochemical profiles in the orbitofrontal cortex of rats: Implications for neural function</atitle><jtitle>Proteomics (Weinheim)</jtitle><addtitle>Proteomics</addtitle><date>2016-11</date><risdate>2016</risdate><volume>16</volume><issue>22</issue><spage>2894</spage><epage>2910</epage><pages>2894-2910</pages><issn>1615-9853</issn><eissn>1615-9861</eissn><abstract>Caffeine is a psychostimulant commonly consumed with high levels of sugar. The increased availability of highly caffeinated, high sugar energy drinks could put some consumers at risk of being exposed to high doses of caffeine and sugar. Notably, research that has examined the consequences of this combination is limited. Here, we explored the effect of chronic exposure to caffeine and/or sugar on behavior and protein levels in the orbitofrontal cortex (OFC) of rats. The OFC brain region has been implicated in neuropsychiatric conditions, including obesity and addiction behaviors. Adult male Sprague–Dawley rats were treated for 26 days with control, caffeine (0.6 g/L), 10% sugar, or combination of both. Locomotor behavior was measured on the first and last day of treatment, then 1 week after treatment. Two hours following final behavioral testing, brains were rapidly removed and prepared for proteomic analysis of the OFC. Label‐free quantitative shotgun analysis revealed that 21, 12, and 23% of proteins identified in the OFC were differentially expressed by sugar and/or caffeine. The results demonstrate that the intake of high levels of sugar and/or low to moderate levels of caffeine has different behavioral consequences. Moreover, each treatment results in a unique proteomic profile with different implications for neural health.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>27588558</pmid><doi>10.1002/pmic.201600032</doi><tpages>17</tpages></addata></record> |
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| subjects | Addictions Animal proteomics Animals Behavior Behavior, Animal - drug effects Beverages Beverages - adverse effects Brain Caffeine Caffeine - adverse effects Caffeine - pharmacology Central Nervous System Stimulants - adverse effects Central Nervous System Stimulants - pharmacology Chronic exposure Dietary Carbohydrates - adverse effects Dietary Carbohydrates - pharmacology Exposure Hyperactivity Locomotion - drug effects Male Neurological disease Orbitofrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Proteins Proteome - analysis Proteome - metabolism Proteomics Rats Rats, Sprague-Dawley Signal Transduction - drug effects Sugar Weight Gain - drug effects |
| title | Extended exposure to sugar and/or caffeine produces distinct behavioral and neurochemical profiles in the orbitofrontal cortex of rats: Implications for neural function |
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