Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow
Background and Objective The objective of the study was to investigate the splanchnic blood flow velocity and oximetry response to blood transfusion in preterm infants according to postnatal age. Materials and Methods Preterm infants receiving blood transfusion were recruited to three groups: 1–7 (g...
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| Veröffentlicht in: | Vox sanguinis 2016-11, Vol.111 (4), p.399-408 |
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| creator | Banerjee, J. Leung, T. S. Aladangady, N. |
| description | Background and Objective
The objective of the study was to investigate the splanchnic blood flow velocity and oximetry response to blood transfusion in preterm infants according to postnatal age.
Materials and Methods
Preterm infants receiving blood transfusion were recruited to three groups: 1–7 (group 1; n = 20), 8–28 (group 2; n = 21) and ≥29 days of life (group 3; n = 18). Superior mesenteric artery (SMA) peak systolic (PSV) and diastolic velocities were measured 30–60 min pre‐ and post‐transfusion using Doppler ultrasound scan. Splanchnic tissue haemoglobin index (sTHI), tissue oxygenation index (sTOI) and fractional tissue oxygen extraction (sFTOE) were measured from 15–20 min before to post‐transfusion using near‐infrared spectroscopy.
Results
The mean pretransfusion Hb in group 1, 2 and 3 was 11, 10 and 9 g/dl, respectively. The mean (SD) pretransfusion SMA PSV in group 1, 2 and 3 was 0·63 (0·32), 0·81 (0·33) and 0·97 (0·40) m/s, respectively, and this did not change significantly following transfusion. The mean (SD) pretransfusion sTOI in group 1, 2 and 3 was 36·7 (19·3), 44·6 (10·4) and 41·3 (10·4)%, respectively. The sTHI and sTOI increased (P < 0·01), and sFTOE decreased (P < 0·01) following transfusion in all groups. On multivariate analysis, changes in SMA PSV and sTOI following blood transfusion were not associated with PDA, feeding, pretransfusion Hb and mean blood pressure.
Conclusion
Pretransfusion baseline splanchnic tissue oximetry and blood flow velocity varied with postnatal age. Blood transfusion improved intestinal tissue oxygenation without altering mesenteric blood flow velocity irrespective of postnatal ages. |
| doi_str_mv | 10.1111/vox.12436 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1850774259</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1841796731</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4596-fc5fc8f9dadb01210a1a6e1331f9c566eedd07f925c76001fd332e9603dd3a43</originalsourceid><addsrcrecordid>eNqNkU9vEzEQxS0EomnhwBdAK3GBw7bjf7vxESIISFV7qVrExXLWNrh418H2Nsm3r5Nte0BCwhePRr_3ZuyH0BsMp7ics7uwPcWE0eYZmmFGaA0Mw3M0A2CkFgDtETpO6RYA5mTOX6Ij0nIQhMIM-U8-BF3lqIZkx-TCULmhWkeTTexLadWQU-X6dQx3phRDNim7Qfkqu5RGU4Xt7qcZVN4rNy7_CmOulC_qqVXMVocJ1ofNK_TCKp_M64f7BF19-Xy1-FqfXy6_LT6e1x3joqltx203t0IrvQJMMCisGoMpxVZ0vGmM0RpaKwjv2gYAW00pMaIBqjVVjJ6g95NtWfrPWPaVvUud8V4NJoxJ4jmHtmWEi_9AGW5F01Jc0Hd_obdhjOUnDhTnAETsZ3-YqC6GlKKxch1dr-JOYpD7sGQJSx7CKuzbB8dx1Rv9RD6mU4CzCdg4b3b_dpLXl98fLetJ4VI22yeFir9leUTL5c3FUrLlDf1xLS7kgt4Ddqyu_g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1845500294</pqid></control><display><type>article</type><title>Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Banerjee, J. ; Leung, T. S. ; Aladangady, N.</creator><creatorcontrib>Banerjee, J. ; Leung, T. S. ; Aladangady, N.</creatorcontrib><description>Background and Objective
The objective of the study was to investigate the splanchnic blood flow velocity and oximetry response to blood transfusion in preterm infants according to postnatal age.
Materials and Methods
Preterm infants receiving blood transfusion were recruited to three groups: 1–7 (group 1; n = 20), 8–28 (group 2; n = 21) and ≥29 days of life (group 3; n = 18). Superior mesenteric artery (SMA) peak systolic (PSV) and diastolic velocities were measured 30–60 min pre‐ and post‐transfusion using Doppler ultrasound scan. Splanchnic tissue haemoglobin index (sTHI), tissue oxygenation index (sTOI) and fractional tissue oxygen extraction (sFTOE) were measured from 15–20 min before to post‐transfusion using near‐infrared spectroscopy.
Results
The mean pretransfusion Hb in group 1, 2 and 3 was 11, 10 and 9 g/dl, respectively. The mean (SD) pretransfusion SMA PSV in group 1, 2 and 3 was 0·63 (0·32), 0·81 (0·33) and 0·97 (0·40) m/s, respectively, and this did not change significantly following transfusion. The mean (SD) pretransfusion sTOI in group 1, 2 and 3 was 36·7 (19·3), 44·6 (10·4) and 41·3 (10·4)%, respectively. The sTHI and sTOI increased (P < 0·01), and sFTOE decreased (P < 0·01) following transfusion in all groups. On multivariate analysis, changes in SMA PSV and sTOI following blood transfusion were not associated with PDA, feeding, pretransfusion Hb and mean blood pressure.
Conclusion
Pretransfusion baseline splanchnic tissue oximetry and blood flow velocity varied with postnatal age. Blood transfusion improved intestinal tissue oxygenation without altering mesenteric blood flow velocity irrespective of postnatal ages.</description><identifier>ISSN: 0042-9007</identifier><identifier>EISSN: 1423-0410</identifier><identifier>DOI: 10.1111/vox.12436</identifier><identifier>PMID: 27509230</identifier><identifier>CODEN: VOSAAD</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Blood Flow Velocity ; Blood Transfusion ; Blood transfusions ; Female ; Flow velocity ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Male ; Mesenteric Artery, Superior - physiopathology ; Multivariate analysis ; Oxygen - metabolism ; Regional Blood Flow ; Splanchnic Circulation ; strategy ; transfusion ; transfusion - pediatrics ; transfusion medicine (in general) ; Treatment Outcome</subject><ispartof>Vox sanguinis, 2016-11, Vol.111 (4), p.399-408</ispartof><rights>2016 International Society of Blood Transfusion</rights><rights>2016 International Society of Blood Transfusion.</rights><rights>Copyright © 2016 International Society of Blood Transfusion</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4596-fc5fc8f9dadb01210a1a6e1331f9c566eedd07f925c76001fd332e9603dd3a43</citedby><cites>FETCH-LOGICAL-c4596-fc5fc8f9dadb01210a1a6e1331f9c566eedd07f925c76001fd332e9603dd3a43</cites><orcidid>0000-0002-7765-8439</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvox.12436$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvox.12436$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27509230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banerjee, J.</creatorcontrib><creatorcontrib>Leung, T. S.</creatorcontrib><creatorcontrib>Aladangady, N.</creatorcontrib><title>Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow</title><title>Vox sanguinis</title><addtitle>Vox Sang</addtitle><description>Background and Objective
The objective of the study was to investigate the splanchnic blood flow velocity and oximetry response to blood transfusion in preterm infants according to postnatal age.
Materials and Methods
Preterm infants receiving blood transfusion were recruited to three groups: 1–7 (group 1; n = 20), 8–28 (group 2; n = 21) and ≥29 days of life (group 3; n = 18). Superior mesenteric artery (SMA) peak systolic (PSV) and diastolic velocities were measured 30–60 min pre‐ and post‐transfusion using Doppler ultrasound scan. Splanchnic tissue haemoglobin index (sTHI), tissue oxygenation index (sTOI) and fractional tissue oxygen extraction (sFTOE) were measured from 15–20 min before to post‐transfusion using near‐infrared spectroscopy.
Results
The mean pretransfusion Hb in group 1, 2 and 3 was 11, 10 and 9 g/dl, respectively. The mean (SD) pretransfusion SMA PSV in group 1, 2 and 3 was 0·63 (0·32), 0·81 (0·33) and 0·97 (0·40) m/s, respectively, and this did not change significantly following transfusion. The mean (SD) pretransfusion sTOI in group 1, 2 and 3 was 36·7 (19·3), 44·6 (10·4) and 41·3 (10·4)%, respectively. The sTHI and sTOI increased (P < 0·01), and sFTOE decreased (P < 0·01) following transfusion in all groups. On multivariate analysis, changes in SMA PSV and sTOI following blood transfusion were not associated with PDA, feeding, pretransfusion Hb and mean blood pressure.
Conclusion
Pretransfusion baseline splanchnic tissue oximetry and blood flow velocity varied with postnatal age. Blood transfusion improved intestinal tissue oxygenation without altering mesenteric blood flow velocity irrespective of postnatal ages.</description><subject>Blood Flow Velocity</subject><subject>Blood Transfusion</subject><subject>Blood transfusions</subject><subject>Female</subject><subject>Flow velocity</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Male</subject><subject>Mesenteric Artery, Superior - physiopathology</subject><subject>Multivariate analysis</subject><subject>Oxygen - metabolism</subject><subject>Regional Blood Flow</subject><subject>Splanchnic Circulation</subject><subject>strategy</subject><subject>transfusion</subject><subject>transfusion - pediatrics</subject><subject>transfusion medicine (in general)</subject><subject>Treatment Outcome</subject><issn>0042-9007</issn><issn>1423-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9vEzEQxS0EomnhwBdAK3GBw7bjf7vxESIISFV7qVrExXLWNrh418H2Nsm3r5Nte0BCwhePRr_3ZuyH0BsMp7ics7uwPcWE0eYZmmFGaA0Mw3M0A2CkFgDtETpO6RYA5mTOX6Ij0nIQhMIM-U8-BF3lqIZkx-TCULmhWkeTTexLadWQU-X6dQx3phRDNim7Qfkqu5RGU4Xt7qcZVN4rNy7_CmOulC_qqVXMVocJ1ofNK_TCKp_M64f7BF19-Xy1-FqfXy6_LT6e1x3joqltx203t0IrvQJMMCisGoMpxVZ0vGmM0RpaKwjv2gYAW00pMaIBqjVVjJ6g95NtWfrPWPaVvUud8V4NJoxJ4jmHtmWEi_9AGW5F01Jc0Hd_obdhjOUnDhTnAETsZ3-YqC6GlKKxch1dr-JOYpD7sGQJSx7CKuzbB8dx1Rv9RD6mU4CzCdg4b3b_dpLXl98fLetJ4VI22yeFir9leUTL5c3FUrLlDf1xLS7kgt4Ddqyu_g</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Banerjee, J.</creator><creator>Leung, T. S.</creator><creator>Aladangady, N.</creator><general>Blackwell Publishing Ltd</general><general>S. Karger AG</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7765-8439</orcidid></search><sort><creationdate>201611</creationdate><title>Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow</title><author>Banerjee, J. ; Leung, T. S. ; Aladangady, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4596-fc5fc8f9dadb01210a1a6e1331f9c566eedd07f925c76001fd332e9603dd3a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Blood Flow Velocity</topic><topic>Blood Transfusion</topic><topic>Blood transfusions</topic><topic>Female</topic><topic>Flow velocity</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Male</topic><topic>Mesenteric Artery, Superior - physiopathology</topic><topic>Multivariate analysis</topic><topic>Oxygen - metabolism</topic><topic>Regional Blood Flow</topic><topic>Splanchnic Circulation</topic><topic>strategy</topic><topic>transfusion</topic><topic>transfusion - pediatrics</topic><topic>transfusion medicine (in general)</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banerjee, J.</creatorcontrib><creatorcontrib>Leung, T. S.</creatorcontrib><creatorcontrib>Aladangady, N.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Vox sanguinis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banerjee, J.</au><au>Leung, T. S.</au><au>Aladangady, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow</atitle><jtitle>Vox sanguinis</jtitle><addtitle>Vox Sang</addtitle><date>2016-11</date><risdate>2016</risdate><volume>111</volume><issue>4</issue><spage>399</spage><epage>408</epage><pages>399-408</pages><issn>0042-9007</issn><eissn>1423-0410</eissn><coden>VOSAAD</coden><abstract>Background and Objective
The objective of the study was to investigate the splanchnic blood flow velocity and oximetry response to blood transfusion in preterm infants according to postnatal age.
Materials and Methods
Preterm infants receiving blood transfusion were recruited to three groups: 1–7 (group 1; n = 20), 8–28 (group 2; n = 21) and ≥29 days of life (group 3; n = 18). Superior mesenteric artery (SMA) peak systolic (PSV) and diastolic velocities were measured 30–60 min pre‐ and post‐transfusion using Doppler ultrasound scan. Splanchnic tissue haemoglobin index (sTHI), tissue oxygenation index (sTOI) and fractional tissue oxygen extraction (sFTOE) were measured from 15–20 min before to post‐transfusion using near‐infrared spectroscopy.
Results
The mean pretransfusion Hb in group 1, 2 and 3 was 11, 10 and 9 g/dl, respectively. The mean (SD) pretransfusion SMA PSV in group 1, 2 and 3 was 0·63 (0·32), 0·81 (0·33) and 0·97 (0·40) m/s, respectively, and this did not change significantly following transfusion. The mean (SD) pretransfusion sTOI in group 1, 2 and 3 was 36·7 (19·3), 44·6 (10·4) and 41·3 (10·4)%, respectively. The sTHI and sTOI increased (P < 0·01), and sFTOE decreased (P < 0·01) following transfusion in all groups. On multivariate analysis, changes in SMA PSV and sTOI following blood transfusion were not associated with PDA, feeding, pretransfusion Hb and mean blood pressure.
Conclusion
Pretransfusion baseline splanchnic tissue oximetry and blood flow velocity varied with postnatal age. Blood transfusion improved intestinal tissue oxygenation without altering mesenteric blood flow velocity irrespective of postnatal ages.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27509230</pmid><doi>10.1111/vox.12436</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7765-8439</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Vox sanguinis, 2016-11, Vol.111 (4), p.399-408 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Blood Flow Velocity Blood Transfusion Blood transfusions Female Flow velocity Humans Infant Infant, Newborn Infant, Premature Male Mesenteric Artery, Superior - physiopathology Multivariate analysis Oxygen - metabolism Regional Blood Flow Splanchnic Circulation strategy transfusion transfusion - pediatrics transfusion medicine (in general) Treatment Outcome |
| title | Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow |
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