Polycarbonate and polystyrene nanoplastic particles act as stressors to the innate immune system of fathead minnow (Pimephales promelas)
Water pollution with large‐scale and small‐scale plastic litter is an area of growing concern. Macro‐plastic litter is a well‐known threat to aquatic wildlife; however, the effects of micro‐sized and nano‐sized plastic particles on the health of organisms are not well understood. Small‐scale plastic...
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| Veröffentlicht in: | Environmental toxicology and chemistry 2016-12, Vol.35 (12), p.3093-3100 |
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| creator | Greven, Anne-Catherine Merk, Teresa Karagöz, Filiz Mohr, Kristin Klapper, Markus Jovanović, Boris Palić, Dušan |
| description | Water pollution with large‐scale and small‐scale plastic litter is an area of growing concern. Macro‐plastic litter is a well‐known threat to aquatic wildlife; however, the effects of micro‐sized and nano‐sized plastic particles on the health of organisms are not well understood. Small‐scale plastic particles can easily be ingested by various aquatic organisms and potentially interfere with their immune system; therefore, the authors used a freshwater fish species as a model organism for nanoplastic exposure. Characterization of polystyrene (41.0 nm) and polycarbonate (158.7 nm) nanoplastic particles (PSNPs and PCNPs, respectively) in plasma was performed, and the effects of PSNPs and PCNPs on the innate immune system of fathead minnow were investigated. In vitro effects of PSNPs and PCNPs on neutrophil function were determined using a battery of neutrophil function assays. Exposure of neutrophils to PSNPs or PCNPs caused significant increases in degranulation of primary granules and neutrophil extracellular trap release compared to a nontreated control, whereas oxidative burst was less affected. The present study outlines the stress response of the cellular component of fish innate immune system to polystyrene and polycarbonate nanoparticles/aggregates and indicates their potential to interfere with disease resistance in fish populations. Environ Toxicol Chem 2016;35:3093–3100. © 2016 SETAC |
| doi_str_mv | 10.1002/etc.3501 |
| format | Article |
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Macro‐plastic litter is a well‐known threat to aquatic wildlife; however, the effects of micro‐sized and nano‐sized plastic particles on the health of organisms are not well understood. Small‐scale plastic particles can easily be ingested by various aquatic organisms and potentially interfere with their immune system; therefore, the authors used a freshwater fish species as a model organism for nanoplastic exposure. Characterization of polystyrene (41.0 nm) and polycarbonate (158.7 nm) nanoplastic particles (PSNPs and PCNPs, respectively) in plasma was performed, and the effects of PSNPs and PCNPs on the innate immune system of fathead minnow were investigated. In vitro effects of PSNPs and PCNPs on neutrophil function were determined using a battery of neutrophil function assays. Exposure of neutrophils to PSNPs or PCNPs caused significant increases in degranulation of primary granules and neutrophil extracellular trap release compared to a nontreated control, whereas oxidative burst was less affected. The present study outlines the stress response of the cellular component of fish innate immune system to polystyrene and polycarbonate nanoparticles/aggregates and indicates their potential to interfere with disease resistance in fish populations. 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Macro‐plastic litter is a well‐known threat to aquatic wildlife; however, the effects of micro‐sized and nano‐sized plastic particles on the health of organisms are not well understood. Small‐scale plastic particles can easily be ingested by various aquatic organisms and potentially interfere with their immune system; therefore, the authors used a freshwater fish species as a model organism for nanoplastic exposure. Characterization of polystyrene (41.0 nm) and polycarbonate (158.7 nm) nanoplastic particles (PSNPs and PCNPs, respectively) in plasma was performed, and the effects of PSNPs and PCNPs on the innate immune system of fathead minnow were investigated. In vitro effects of PSNPs and PCNPs on neutrophil function were determined using a battery of neutrophil function assays. Exposure of neutrophils to PSNPs or PCNPs caused significant increases in degranulation of primary granules and neutrophil extracellular trap release compared to a nontreated control, whereas oxidative burst was less affected. The present study outlines the stress response of the cellular component of fish innate immune system to polystyrene and polycarbonate nanoparticles/aggregates and indicates their potential to interfere with disease resistance in fish populations. Environ Toxicol Chem 2016;35:3093–3100. © 2016 SETAC</description><subject>Animals</subject><subject>Aquatic organisms</subject><subject>Aquatic toxicology</subject><subject>Cyprinidae - immunology</subject><subject>Cyprinidae - metabolism</subject><subject>Disease resistance</subject><subject>Dynamic Light Scattering</subject><subject>Fish</subject><subject>Fish diseases</subject><subject>Fish innate immunity</subject><subject>Fish populations</subject><subject>Freshwater fish</subject><subject>Immune system</subject><subject>Immunity, Innate - drug effects</subject><subject>Immunotoxicity</subject><subject>Litter</subject><subject>Microplastic</subject><subject>Nanoparticles - analysis</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - toxicity</subject><subject>Nanotoxicology</subject><subject>Neutrophil function</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - metabolism</subject><subject>Particle Size</subject><subject>Phagocytosis - drug effects</subject><subject>Pimephales promelas</subject><subject>Plastics</subject><subject>Polycarbonate nanoplastic</subject><subject>Polycarboxylate Cement - chemistry</subject><subject>Polystyrene</subject><subject>Polystyrene nanoplastic</subject><subject>Polystyrenes - chemistry</subject><subject>Respiratory Burst - drug effects</subject><subject>Secretory Vesicles - metabolism</subject><subject>Toxicology</subject><subject>Water pollution</subject><subject>Wildlife</subject><issn>0730-7268</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu1TAQhi1ERQ8FiSdAlti0ixRf4kuWUMpppRa6ALG0XHuipiRxsBOV8wY8NnPooaqQWM3I8_kbyz8hrzg75oyJtzCHY6kYf0JWXClRWc3tU7JiRrLKCG33yfNSbhnjummaZ2RfGIEzLlfk11XqN8Hn6zT6GagfI53wpMybDCPQ0Y9p6n2Zu0Ann7H0UKgPM_WFljlDKSkXOic63wDtxj-SbhgWvFvQAgNNLW09Tn2kAwLpjh5edQNMN36rmnIaABccvSB7re8LvNzVA_L14-mXk7Pq4vP6_OTdRRWUMLyKFljUWgUdwQiporGSCdsEgW0jrKyFCLW3tdLYNlaYqAM3bRODUUJxeUAO7724-ccCZXZDVwL0vR8hLcVxq5gxghuG6Jt_0Nu05BFfh1RdW417HwlDTqVkaN2Uu8HnjePMbdNxmI7bpoPo651wuR4gPoB_40Cgugfuuh42_xU5ZHbCHd_hV_984H3-7rSRRrlvn9Zu_YHX-ky8d5fyN_rIp_A</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Greven, Anne-Catherine</creator><creator>Merk, Teresa</creator><creator>Karagöz, Filiz</creator><creator>Mohr, Kristin</creator><creator>Klapper, Markus</creator><creator>Jovanović, Boris</creator><creator>Palić, Dušan</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7TV</scope></search><sort><creationdate>201612</creationdate><title>Polycarbonate and polystyrene nanoplastic particles act as stressors to the innate immune system of fathead minnow (Pimephales promelas)</title><author>Greven, Anne-Catherine ; 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Macro‐plastic litter is a well‐known threat to aquatic wildlife; however, the effects of micro‐sized and nano‐sized plastic particles on the health of organisms are not well understood. Small‐scale plastic particles can easily be ingested by various aquatic organisms and potentially interfere with their immune system; therefore, the authors used a freshwater fish species as a model organism for nanoplastic exposure. Characterization of polystyrene (41.0 nm) and polycarbonate (158.7 nm) nanoplastic particles (PSNPs and PCNPs, respectively) in plasma was performed, and the effects of PSNPs and PCNPs on the innate immune system of fathead minnow were investigated. In vitro effects of PSNPs and PCNPs on neutrophil function were determined using a battery of neutrophil function assays. Exposure of neutrophils to PSNPs or PCNPs caused significant increases in degranulation of primary granules and neutrophil extracellular trap release compared to a nontreated control, whereas oxidative burst was less affected. The present study outlines the stress response of the cellular component of fish innate immune system to polystyrene and polycarbonate nanoparticles/aggregates and indicates their potential to interfere with disease resistance in fish populations. Environ Toxicol Chem 2016;35:3093–3100. © 2016 SETAC</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27207313</pmid><doi>10.1002/etc.3501</doi><tpages>8</tpages></addata></record> |
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| ispartof | Environmental toxicology and chemistry, 2016-12, Vol.35 (12), p.3093-3100 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Aquatic organisms Aquatic toxicology Cyprinidae - immunology Cyprinidae - metabolism Disease resistance Dynamic Light Scattering Fish Fish diseases Fish innate immunity Fish populations Freshwater fish Immune system Immunity, Innate - drug effects Immunotoxicity Litter Microplastic Nanoparticles - analysis Nanoparticles - chemistry Nanoparticles - toxicity Nanotoxicology Neutrophil function Neutrophils - drug effects Neutrophils - metabolism Particle Size Phagocytosis - drug effects Pimephales promelas Plastics Polycarbonate nanoplastic Polycarboxylate Cement - chemistry Polystyrene Polystyrene nanoplastic Polystyrenes - chemistry Respiratory Burst - drug effects Secretory Vesicles - metabolism Toxicology Water pollution Wildlife |
| title | Polycarbonate and polystyrene nanoplastic particles act as stressors to the innate immune system of fathead minnow (Pimephales promelas) |
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