GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App

ABSTRACT It has been suggested that increased GABAergic innervation in the hippocampus plays a significant role in cognitive dysfunction in Down syndrome (DS). Bolstering this notion, are studies linking hyper‐innervation of the dentate gyrus (DG) by GABAergic terminals to failure in LTP induction i...

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Veröffentlicht in:	Hippocampus 2016-12, Vol.26 (12), p.1641-1654
Hauptverfasser:	Mojabi, Fatemeh S., Fahimi, Atoossa, Moghadam, Shahrzad, Moghadam, Sarah, Windy McNerneny, M., Ponnusamy, Ravikumar, Kleschevnikov, Alexander, Mobley, William C., Salehi, Ahmad
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Aging - pathology Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals basket cells Cyclin-Dependent Kinase 5 - metabolism Dentate Gyrus - metabolism Dentate Gyrus - pathology Disease Models, Animal down syndrome Down Syndrome - metabolism Down Syndrome - pathology GABA GABAergic Neurons - metabolism GABAergic Neurons - pathology gamma-Aminobutyric Acid - metabolism Immunohistochemistry Interneurons - metabolism Interneurons - pathology Male Mice, Inbred C57BL Mice, Transgenic parvalbumin Parvalbumins - metabolism Receptors, Kainic Acid - metabolism Synapses - metabolism Synapses - pathology Ts65Dn
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