Suppressive Effects of Copper Sulfate Accumulation on the Spermatogenesis of Rats
This study investigated the effect of copper sulfate (CuSO 4 ) in the rat spermatogenesis. Forty male rats, weighing 70–80 g, were randomly divided into four groups: control group (CG, 0 mg/kg BW), low-dose group (LG, 100 mg/kg BW), mid-dose group (MG, 200 mg/kg BW), and high-dose group (HG, 400 mg/...
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| Veröffentlicht in: | Biological trace element research 2016-12, Vol.174 (2), p.356-361 |
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| creator | Liu, J. Y. Yang, X. Sun, X. D. Zhuang, C. C. Xu, F. B. Li, Y. F. |
| description | This study investigated the effect of copper sulfate (CuSO
4
) in the rat spermatogenesis. Forty male rats, weighing 70–80 g, were randomly divided into four groups: control group (CG, 0 mg/kg BW), low-dose group (LG, 100 mg/kg BW), mid-dose group (MG, 200 mg/kg BW), and high-dose group (HG, 400 mg/kg BW). Rats were administered CuSO
4
by gavage for 30 days. A variety of measurements were taken including the testis coefficients, the sperm count, the abnormal malformation rate, testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) concentrations in the serum. In addition, glutathione peroxidase (GSH-P
x
) and superoxide dismutase (SOD) activities, and malondialdehyde (MDA) concentration in the testis were determined. The results showed that in the CuSO
4
-treated groups, the testis coefficients, sperm count, T, LH, and FSH concentrations, and GSH-P
x
and SOD activities decreased, while the abnormal malformation rate and MDA concentration increased, compared with the CG. It indicates that CuSO
4
exposure impairs the sperm quality and inhibits secretion of sex hormone and gonadotropin, and testis anti-oxidative function, suppressing the rat spermatogenesis. |
| doi_str_mv | 10.1007/s12011-016-0710-7 |
| format | Article |
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4
) in the rat spermatogenesis. Forty male rats, weighing 70–80 g, were randomly divided into four groups: control group (CG, 0 mg/kg BW), low-dose group (LG, 100 mg/kg BW), mid-dose group (MG, 200 mg/kg BW), and high-dose group (HG, 400 mg/kg BW). Rats were administered CuSO
4
by gavage for 30 days. A variety of measurements were taken including the testis coefficients, the sperm count, the abnormal malformation rate, testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) concentrations in the serum. In addition, glutathione peroxidase (GSH-P
x
) and superoxide dismutase (SOD) activities, and malondialdehyde (MDA) concentration in the testis were determined. The results showed that in the CuSO
4
-treated groups, the testis coefficients, sperm count, T, LH, and FSH concentrations, and GSH-P
x
and SOD activities decreased, while the abnormal malformation rate and MDA concentration increased, compared with the CG. It indicates that CuSO
4
exposure impairs the sperm quality and inhibits secretion of sex hormone and gonadotropin, and testis anti-oxidative function, suppressing the rat spermatogenesis.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-016-0710-7</identifier><identifier>PMID: 27129317</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Copper ; Copper sulfate ; Copper Sulfate - pharmacokinetics ; Copper Sulfate - toxicity ; Dose-Response Relationship, Drug ; Gonadal Steroid Hormones - blood ; Life Sciences ; Male ; Malondialdehyde - metabolism ; Nutrition ; Oncology ; Oxidative stress ; Rats ; Rats, Wistar ; Rodents ; Sperm Count ; Spermatogenesis ; Spermatogenesis - drug effects ; Spermatozoa - metabolism ; Spermatozoa - pathology ; Sulfates ; Superoxide Dismutase - metabolism ; Toxicity</subject><ispartof>Biological trace element research, 2016-12, Vol.174 (2), p.356-361</ispartof><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-8558b23778ac36707392d02e0739365f8e9bbff751b10150abf847cb9d0667f73</citedby><cites>FETCH-LOGICAL-c405t-8558b23778ac36707392d02e0739365f8e9bbff751b10150abf847cb9d0667f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-016-0710-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-016-0710-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27129317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, J. Y.</creatorcontrib><creatorcontrib>Yang, X.</creatorcontrib><creatorcontrib>Sun, X. D.</creatorcontrib><creatorcontrib>Zhuang, C. C.</creatorcontrib><creatorcontrib>Xu, F. B.</creatorcontrib><creatorcontrib>Li, Y. F.</creatorcontrib><title>Suppressive Effects of Copper Sulfate Accumulation on the Spermatogenesis of Rats</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>This study investigated the effect of copper sulfate (CuSO
4
) in the rat spermatogenesis. Forty male rats, weighing 70–80 g, were randomly divided into four groups: control group (CG, 0 mg/kg BW), low-dose group (LG, 100 mg/kg BW), mid-dose group (MG, 200 mg/kg BW), and high-dose group (HG, 400 mg/kg BW). Rats were administered CuSO
4
by gavage for 30 days. A variety of measurements were taken including the testis coefficients, the sperm count, the abnormal malformation rate, testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) concentrations in the serum. In addition, glutathione peroxidase (GSH-P
x
) and superoxide dismutase (SOD) activities, and malondialdehyde (MDA) concentration in the testis were determined. The results showed that in the CuSO
4
-treated groups, the testis coefficients, sperm count, T, LH, and FSH concentrations, and GSH-P
x
and SOD activities decreased, while the abnormal malformation rate and MDA concentration increased, compared with the CG. It indicates that CuSO
4
exposure impairs the sperm quality and inhibits secretion of sex hormone and gonadotropin, and testis anti-oxidative function, suppressing the rat spermatogenesis.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Copper</subject><subject>Copper sulfate</subject><subject>Copper Sulfate - pharmacokinetics</subject><subject>Copper Sulfate - toxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Oxidative stress</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Sperm Count</subject><subject>Spermatogenesis</subject><subject>Spermatogenesis - drug effects</subject><subject>Spermatozoa - metabolism</subject><subject>Spermatozoa - pathology</subject><subject>Sulfates</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Toxicity</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkV1LHTEQhkOp6NH2B3hTFnrjzepMsvnYSzlYFQTRo9chu2eiK_vVZLfgvzfHo0UKBSGQCfPMm4SHsUOEYwTQJxE5IOaAKgeNkOsvbIFSlunE4StbpIbIi9IUe2w_xicA1LwUu2yPa0wF6gW7Wc3jGCjG5g9lZ95TPcVs8NlyGEcK2WpuvZsoO63ruZtbNzVDn6U1PVK2SkDnpuGBeorN69Stm-I3tuNdG-n7237A7n-d3S0v8qvr88vl6VVeFyCn3EhpKi60Nq4WSoMWJV8Dp00hlPSGyqryXkusEFCCq7wpdF2Va1BKey0O2NE2dwzD75niZLsm1tS2rqdhjhaNBK1K4PITKFfKFKBEQn_-gz4Nc-jTRxIlCi2NEiZRuKXqMMQYyNsxNJ0LzxbBbtTYrRqbDNiNGrt574-35LnqaP134t1FAvgWiKnVP1D4cPV_U18AKNSWuw</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Liu, J. Y.</creator><creator>Yang, X.</creator><creator>Sun, X. D.</creator><creator>Zhuang, C. C.</creator><creator>Xu, F. B.</creator><creator>Li, Y. F.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Suppressive Effects of Copper Sulfate Accumulation on the Spermatogenesis of Rats</title><author>Liu, J. Y. ; Yang, X. ; Sun, X. D. ; Zhuang, C. C. ; Xu, F. B. ; Li, Y. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-8558b23778ac36707392d02e0739365f8e9bbff751b10150abf847cb9d0667f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Copper</topic><topic>Copper sulfate</topic><topic>Copper Sulfate - pharmacokinetics</topic><topic>Copper Sulfate - toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Oxidative stress</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Sperm Count</topic><topic>Spermatogenesis</topic><topic>Spermatogenesis - drug effects</topic><topic>Spermatozoa - metabolism</topic><topic>Spermatozoa - pathology</topic><topic>Sulfates</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, J. 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Y.</au><au>Yang, X.</au><au>Sun, X. D.</au><au>Zhuang, C. C.</au><au>Xu, F. B.</au><au>Li, Y. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppressive Effects of Copper Sulfate Accumulation on the Spermatogenesis of Rats</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>174</volume><issue>2</issue><spage>356</spage><epage>361</epage><pages>356-361</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>This study investigated the effect of copper sulfate (CuSO
4
) in the rat spermatogenesis. Forty male rats, weighing 70–80 g, were randomly divided into four groups: control group (CG, 0 mg/kg BW), low-dose group (LG, 100 mg/kg BW), mid-dose group (MG, 200 mg/kg BW), and high-dose group (HG, 400 mg/kg BW). Rats were administered CuSO
4
by gavage for 30 days. A variety of measurements were taken including the testis coefficients, the sperm count, the abnormal malformation rate, testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) concentrations in the serum. In addition, glutathione peroxidase (GSH-P
x
) and superoxide dismutase (SOD) activities, and malondialdehyde (MDA) concentration in the testis were determined. The results showed that in the CuSO
4
-treated groups, the testis coefficients, sperm count, T, LH, and FSH concentrations, and GSH-P
x
and SOD activities decreased, while the abnormal malformation rate and MDA concentration increased, compared with the CG. It indicates that CuSO
4
exposure impairs the sperm quality and inhibits secretion of sex hormone and gonadotropin, and testis anti-oxidative function, suppressing the rat spermatogenesis.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27129317</pmid><doi>10.1007/s12011-016-0710-7</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biological trace element research, 2016-12, Vol.174 (2), p.356-361 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biochemistry Biomedical and Life Sciences Biotechnology Copper Copper sulfate Copper Sulfate - pharmacokinetics Copper Sulfate - toxicity Dose-Response Relationship, Drug Gonadal Steroid Hormones - blood Life Sciences Male Malondialdehyde - metabolism Nutrition Oncology Oxidative stress Rats Rats, Wistar Rodents Sperm Count Spermatogenesis Spermatogenesis - drug effects Spermatozoa - metabolism Spermatozoa - pathology Sulfates Superoxide Dismutase - metabolism Toxicity |
| title | Suppressive Effects of Copper Sulfate Accumulation on the Spermatogenesis of Rats |
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