Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes

Oxidative damage of nucleotides within DNA or precursor pools caused by oxygen radicals is thought to play an important role in spontaneous mutagenesis, as well as carcinogenesis and aging. In particular, 8-oxodGTP and 2-OHdATP are potent mutagenic substrate for DNA synthesis. Mammalian MTH1 catalyz...

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Veröffentlicht in:	DNA repair 2002-11, Vol.1 (11), p.881-893
Hauptverfasser:	Egashira, Akinori, Yamauchi, Kazumi, Yoshiyama, Kaoru, Kawate, Hisaya, Katsuki, Motoya, Sekiguchi, Mutsuo, Sugimachi, Keizo, Maki, Hisaji, Tsuzuki, Teruhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Pair Mismatch Base Sequence Deoxyguanine Nucleotides - metabolism DNA Damage DNA Mutational Analysis DNA Primers - chemistry DNA Repair DNA Repair Enzymes DNA-Binding Proteins Female Gene Frequency Gene Targeting Genotype Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Molecular Sequence Data MSH2 MTH1 Mutagenesis - drug effects Mutation MutS Homolog 2 Protein Oxidative DNA damage Phosphoric Monoester Hydrolases - physiology Polymerase Chain Reaction Proto-Oncogene Proteins - physiology Ribosomal Proteins - genetics Ribosomal Proteins - metabolism rpsL gene Spleen - metabolism Spontaneous mutagenesis Transgenic mice
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