Ethylenethiourea in urine as an indicator of exposure to mancozeb in vineyard workers
In the present study, the personal exposure to mancozeb and/or ethilenethiourea (ETU) in 13 Italian vineyard workers and in 13 subjects without occupational exposure to pesticides was investigated. With this aim, the level of ETU in urine and the dermal exposure to mancozeb were determined. Baseline...
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| Veröffentlicht in: | Toxicology letters 2002-08, Vol.134 (1), p.133-140 |
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| creator | Colosio, Claudio Fustinoni, S Birindelli, S Bonomi, I De Paschale, G Mammone, T Tiramani, M Vercelli, F Visentin, S Maroni, M |
| description | In the present study, the personal exposure to mancozeb and/or ethilenethiourea (ETU) in 13 Italian vineyard workers and in 13 subjects without occupational exposure to pesticides was investigated. With this aim, the level of ETU in urine and the dermal exposure to mancozeb were determined. Baseline urinary ETU results were lower than the analytical limit of detection for all controls ( |
| doi_str_mv | 10.1016/S0378-4274(02)00182-0 |
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n=7) than in those using closed tractors (
n=5) (16.2 vs. 2.4 μg/g creatinine), but the difference was not significant (
P=0.073). End-shift urinary ETU was positively correlated with dermal exposure to mancozeb determined both over the clothes and on the skin (Spearman's
ρ=0.770 and 0.702,
P=0.009 and 0.024, respectively). Wine consumption positively influenced the excretion of ETU.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/S0378-4274(02)00182-0</identifier><identifier>PMID: 12191871</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Agricultural workers ; Agriculture ; Biological and medical sciences ; Biomarkers - analysis ; Biomonitoring ; Environmental Monitoring - methods ; Ethylenethiourea ; Ethylenethiourea - analysis ; Female ; Fungicides, Industrial - administration & dosage ; Fungicides, Industrial - pharmacokinetics ; Humans ; Male ; Mancozeb ; Maneb - administration & dosage ; Maneb - pharmacokinetics ; Medical sciences ; Occupational Exposure - analysis ; Pesticides, fertilizers and other agrochemicals toxicology ; Skin - chemistry ; Skin Absorption ; Toxicology ; Urine ; Zineb - administration & dosage ; Zineb - pharmacokinetics</subject><ispartof>Toxicology letters, 2002-08, Vol.134 (1), p.133-140</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-59911275f38280f4f02145dbccc5a1ffcbf813d9f9fa61b4618c2f027198eddb3</citedby><cites>FETCH-LOGICAL-c490t-59911275f38280f4f02145dbccc5a1ffcbf813d9f9fa61b4618c2f027198eddb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378427402001820$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13906254$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12191871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colosio, Claudio</creatorcontrib><creatorcontrib>Fustinoni, S</creatorcontrib><creatorcontrib>Birindelli, S</creatorcontrib><creatorcontrib>Bonomi, I</creatorcontrib><creatorcontrib>De Paschale, G</creatorcontrib><creatorcontrib>Mammone, T</creatorcontrib><creatorcontrib>Tiramani, M</creatorcontrib><creatorcontrib>Vercelli, F</creatorcontrib><creatorcontrib>Visentin, S</creatorcontrib><creatorcontrib>Maroni, M</creatorcontrib><title>Ethylenethiourea in urine as an indicator of exposure to mancozeb in vineyard workers</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>In the present study, the personal exposure to mancozeb and/or ethilenethiourea (ETU) in 13 Italian vineyard workers and in 13 subjects without occupational exposure to pesticides was investigated. With this aim, the level of ETU in urine and the dermal exposure to mancozeb were determined. Baseline urinary ETU results were lower than the analytical limit of detection for all controls (<0.5 μg/g creatinine) and for ten workers (median <0.5, range <0.5–3.4 μg/g creatinine). In workers, urinary ETU was significantly increased at the end of shift (2.5, <0.5–95.2 μg/g creatinine) compared with baseline levels. End-shift urinary ETU was higher in operators using open tractors (
n=7) than in those using closed tractors (
n=5) (16.2 vs. 2.4 μg/g creatinine), but the difference was not significant (
P=0.073). End-shift urinary ETU was positively correlated with dermal exposure to mancozeb determined both over the clothes and on the skin (Spearman's
ρ=0.770 and 0.702,
P=0.009 and 0.024, respectively). Wine consumption positively influenced the excretion of ETU.</description><subject>Adult</subject><subject>Agricultural workers</subject><subject>Agriculture</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Biomonitoring</subject><subject>Environmental Monitoring - methods</subject><subject>Ethylenethiourea</subject><subject>Ethylenethiourea - analysis</subject><subject>Female</subject><subject>Fungicides, Industrial - administration & dosage</subject><subject>Fungicides, Industrial - pharmacokinetics</subject><subject>Humans</subject><subject>Male</subject><subject>Mancozeb</subject><subject>Maneb - administration & dosage</subject><subject>Maneb - pharmacokinetics</subject><subject>Medical sciences</subject><subject>Occupational Exposure - analysis</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Skin - chemistry</subject><subject>Skin Absorption</subject><subject>Toxicology</subject><subject>Urine</subject><subject>Zineb - administration & dosage</subject><subject>Zineb - pharmacokinetics</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M9vFCEUwHFibOy6-idouGj0MPoe8wtOjWmqNmnSg_ZMGHik6Oywwkx1-9fLdjf26ImQfN6DfBl7hfABAbuP36DuZdWIvnkH4j0ASlHBE7ZC2auqxk49Zat_5JQ9z_kHAHRN1z5jpyhQFYgrdnMx3-5Gmmi-DXFJZHiY-JLCRNxkbqZydcGaOSYePac_25iL4nPkGzPZeE_DfuCu-J1Jjv-O6Sel_IKdeDNmenk81-zm88X386_V1fWXy_NPV5VtFMxVqxSi6FtfSyHBNx4ENq0brLWtQe_t4CXWTnnlTYdD06G0oqAelSTnhnrN3h72blP8tVCe9SZkS-NoJopL1ihbAFl2rFl7gDbFnBN5vU1hY9JOI-h9T_3QU-9jaRD6oaeGMvf6-MAybMg9Th0DFvDmCEy2ZvSpVAn50dUKOtE2xZ0dHJUcd4GSzjbQZMmFRHbWLob_fOUvYi-SgA</recordid><startdate>20020805</startdate><enddate>20020805</enddate><creator>Colosio, Claudio</creator><creator>Fustinoni, S</creator><creator>Birindelli, S</creator><creator>Bonomi, I</creator><creator>De Paschale, G</creator><creator>Mammone, T</creator><creator>Tiramani, M</creator><creator>Vercelli, F</creator><creator>Visentin, S</creator><creator>Maroni, M</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20020805</creationdate><title>Ethylenethiourea in urine as an indicator of exposure to mancozeb in vineyard workers</title><author>Colosio, Claudio ; Fustinoni, S ; Birindelli, S ; Bonomi, I ; De Paschale, G ; Mammone, T ; Tiramani, M ; Vercelli, F ; Visentin, S ; Maroni, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-59911275f38280f4f02145dbccc5a1ffcbf813d9f9fa61b4618c2f027198eddb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Agricultural workers</topic><topic>Agriculture</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Biomonitoring</topic><topic>Environmental Monitoring - methods</topic><topic>Ethylenethiourea</topic><topic>Ethylenethiourea - analysis</topic><topic>Female</topic><topic>Fungicides, Industrial - administration & dosage</topic><topic>Fungicides, Industrial - pharmacokinetics</topic><topic>Humans</topic><topic>Male</topic><topic>Mancozeb</topic><topic>Maneb - administration & dosage</topic><topic>Maneb - pharmacokinetics</topic><topic>Medical sciences</topic><topic>Occupational Exposure - analysis</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Skin - chemistry</topic><topic>Skin Absorption</topic><topic>Toxicology</topic><topic>Urine</topic><topic>Zineb - administration & dosage</topic><topic>Zineb - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colosio, Claudio</creatorcontrib><creatorcontrib>Fustinoni, S</creatorcontrib><creatorcontrib>Birindelli, S</creatorcontrib><creatorcontrib>Bonomi, I</creatorcontrib><creatorcontrib>De Paschale, G</creatorcontrib><creatorcontrib>Mammone, T</creatorcontrib><creatorcontrib>Tiramani, M</creatorcontrib><creatorcontrib>Vercelli, F</creatorcontrib><creatorcontrib>Visentin, S</creatorcontrib><creatorcontrib>Maroni, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colosio, Claudio</au><au>Fustinoni, S</au><au>Birindelli, S</au><au>Bonomi, I</au><au>De Paschale, G</au><au>Mammone, T</au><au>Tiramani, M</au><au>Vercelli, F</au><au>Visentin, S</au><au>Maroni, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethylenethiourea in urine as an indicator of exposure to mancozeb in vineyard workers</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2002-08-05</date><risdate>2002</risdate><volume>134</volume><issue>1</issue><spage>133</spage><epage>140</epage><pages>133-140</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>In the present study, the personal exposure to mancozeb and/or ethilenethiourea (ETU) in 13 Italian vineyard workers and in 13 subjects without occupational exposure to pesticides was investigated. With this aim, the level of ETU in urine and the dermal exposure to mancozeb were determined. Baseline urinary ETU results were lower than the analytical limit of detection for all controls (<0.5 μg/g creatinine) and for ten workers (median <0.5, range <0.5–3.4 μg/g creatinine). In workers, urinary ETU was significantly increased at the end of shift (2.5, <0.5–95.2 μg/g creatinine) compared with baseline levels. End-shift urinary ETU was higher in operators using open tractors (
n=7) than in those using closed tractors (
n=5) (16.2 vs. 2.4 μg/g creatinine), but the difference was not significant (
P=0.073). End-shift urinary ETU was positively correlated with dermal exposure to mancozeb determined both over the clothes and on the skin (Spearman's
ρ=0.770 and 0.702,
P=0.009 and 0.024, respectively). Wine consumption positively influenced the excretion of ETU.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>12191871</pmid><doi>10.1016/S0378-4274(02)00182-0</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 2002-08, Vol.134 (1), p.133-140 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Agricultural workers Agriculture Biological and medical sciences Biomarkers - analysis Biomonitoring Environmental Monitoring - methods Ethylenethiourea Ethylenethiourea - analysis Female Fungicides, Industrial - administration & dosage Fungicides, Industrial - pharmacokinetics Humans Male Mancozeb Maneb - administration & dosage Maneb - pharmacokinetics Medical sciences Occupational Exposure - analysis Pesticides, fertilizers and other agrochemicals toxicology Skin - chemistry Skin Absorption Toxicology Urine Zineb - administration & dosage Zineb - pharmacokinetics |
| title | Ethylenethiourea in urine as an indicator of exposure to mancozeb in vineyard workers |
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