Construction of a database of benzene biological monitoring
Biological monitoring of occupational exposure to benzene has been conducted in the petroleum, steel and chemical industries. The urinary benzene-specific biomarker, S-phenylmercapturic acid (PMA), was quantified in post-shift samples using a sensitive enzyme-linked immunosorbent assay (ELISA) and e...
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| Veröffentlicht in: | Toxicology letters 2002-08, Vol.134 (1), p.301-304 |
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| creator | Pople, J.E Ball, R.L Padgett, M.J Aston, J.P |
| description | Biological monitoring of occupational exposure to benzene has been conducted in the petroleum, steel and chemical industries. The urinary benzene-specific biomarker, S-phenylmercapturic acid (PMA), was quantified in post-shift samples using a sensitive enzyme-linked immunosorbent assay (ELISA) and expressed as a function of urinary creatinine concentration. The assay, based on a PMA-specific antiserum, is sufficiently sensitive to measure PMA levels in non-occupationally exposed control subjects. The assay delivers batch results in a timely manner which may be as short as 3 h. Samples were analysed from groups of workers engaged in coke oven combustion processes, petroleum refining and decontamination of a benzene land spill. The construction of a database of results provides an index of benzene uptake as a consequence of the respective work processes and tasks and readily enables benchmarking exercises aimed at comparing degrees of exposure across segments of industry. |
| doi_str_mv | 10.1016/S0378-4274(02)00194-7 |
| format | Article |
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The urinary benzene-specific biomarker, S-phenylmercapturic acid (PMA), was quantified in post-shift samples using a sensitive enzyme-linked immunosorbent assay (ELISA) and expressed as a function of urinary creatinine concentration. The assay, based on a PMA-specific antiserum, is sufficiently sensitive to measure PMA levels in non-occupationally exposed control subjects. The assay delivers batch results in a timely manner which may be as short as 3 h. Samples were analysed from groups of workers engaged in coke oven combustion processes, petroleum refining and decontamination of a benzene land spill. 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The urinary benzene-specific biomarker, S-phenylmercapturic acid (PMA), was quantified in post-shift samples using a sensitive enzyme-linked immunosorbent assay (ELISA) and expressed as a function of urinary creatinine concentration. The assay, based on a PMA-specific antiserum, is sufficiently sensitive to measure PMA levels in non-occupationally exposed control subjects. The assay delivers batch results in a timely manner which may be as short as 3 h. Samples were analysed from groups of workers engaged in coke oven combustion processes, petroleum refining and decontamination of a benzene land spill. The construction of a database of results provides an index of benzene uptake as a consequence of the respective work processes and tasks and readily enables benchmarking exercises aimed at comparing degrees of exposure across segments of industry.</description><subject>Acetylcysteine - analogs & derivatives</subject><subject>Acetylcysteine - urine</subject><subject>Benzene - pharmacokinetics</subject><subject>Benzene biological monitoring database</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - urine</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Chemical Industry</subject><subject>Databases, Factual</subject><subject>Environmental Monitoring - methods</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Medical sciences</subject><subject>Occupational Exposure - analysis</subject><subject>Petroleum</subject><subject>PMA-specific</subject><subject>Steel</subject><subject>Tumors</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MtKxDAUgOEgio6XR1C6UXRRzUnTpsGFyOANBBfqOqTJiUQ6iSYdQZ_ejjPo0lUIfOck_ITsAz0FCs3ZI61EW3Im-DFlJ5SC5KVYIxNohSwraOQ6mfySLbKd8yultOFNvUm2gIGEVrIJOZ_GkIc0N4OPoYiu0IXVg-50xsWtw_CFAYvOxz6-eKP7YhaDH2Ly4WWXbDjdZ9xbnTvk-frqaXpb3j_c3E0v70vDGRtKB44hByNYZyxUXCLXHdTGadoCNgIEc85oLhtg1mpeo6xaFBbAdtpyXu2Qo-XetxTf55gHNfPZYN_rgHGeFbRcthzaEdZLaFLMOaFTb8nPdPpUQNWimvqpphZJFGXqp5oS49zB6oF5N0P7N7XKNILDFdB5bOCSDsbnP1dJ2jBRj-5i6XDM8eExqWw8BoPWJzSDstH_85VvnyGJOw</recordid><startdate>20020805</startdate><enddate>20020805</enddate><creator>Pople, J.E</creator><creator>Ball, R.L</creator><creator>Padgett, M.J</creator><creator>Aston, J.P</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20020805</creationdate><title>Construction of a database of benzene biological monitoring</title><author>Pople, J.E ; Ball, R.L ; Padgett, M.J ; Aston, J.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-f1f2e41c72bcd1349e4ab15cfa081e67172ffca49612dda45e938e7d11dbad443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acetylcysteine - analogs & derivatives</topic><topic>Acetylcysteine - urine</topic><topic>Benzene - pharmacokinetics</topic><topic>Benzene biological monitoring database</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - urine</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>Chemical Industry</topic><topic>Databases, Factual</topic><topic>Environmental Monitoring - methods</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Medical sciences</topic><topic>Occupational Exposure - analysis</topic><topic>Petroleum</topic><topic>PMA-specific</topic><topic>Steel</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pople, J.E</creatorcontrib><creatorcontrib>Ball, R.L</creatorcontrib><creatorcontrib>Padgett, M.J</creatorcontrib><creatorcontrib>Aston, J.P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pople, J.E</au><au>Ball, R.L</au><au>Padgett, M.J</au><au>Aston, J.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Construction of a database of benzene biological monitoring</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2002-08-05</date><risdate>2002</risdate><volume>134</volume><issue>1</issue><spage>301</spage><epage>304</epage><pages>301-304</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>Biological monitoring of occupational exposure to benzene has been conducted in the petroleum, steel and chemical industries. The urinary benzene-specific biomarker, S-phenylmercapturic acid (PMA), was quantified in post-shift samples using a sensitive enzyme-linked immunosorbent assay (ELISA) and expressed as a function of urinary creatinine concentration. The assay, based on a PMA-specific antiserum, is sufficiently sensitive to measure PMA levels in non-occupationally exposed control subjects. The assay delivers batch results in a timely manner which may be as short as 3 h. Samples were analysed from groups of workers engaged in coke oven combustion processes, petroleum refining and decontamination of a benzene land spill. 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| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 2002-08, Vol.134 (1), p.301-304 |
| issn | 0378-4274 1879-3169 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcysteine - analogs & derivatives Acetylcysteine - urine Benzene - pharmacokinetics Benzene biological monitoring database Biological and medical sciences Biomarkers - urine Carcinogenesis, carcinogens and anticarcinogens Chemical agents Chemical Industry Databases, Factual Environmental Monitoring - methods Enzyme-Linked Immunosorbent Assay Humans Immunoassay Medical sciences Occupational Exposure - analysis Petroleum PMA-specific Steel Tumors |
| title | Construction of a database of benzene biological monitoring |
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