A repeated 28-day oral dose toxicity study of genistein in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals

In association with the international validation project to establish an OECD Enhanced Test Guideline 407, we performed a 28-day repeated-dose toxicity study of genistein, which is known as a phytoestrogen. Attention was paid to the sensitivity of certain additional parameters, such as histopatholog...

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Veröffentlicht in:	Archives of toxicology 2002-10, Vol.76 (10), p.553-559
Hauptverfasser:	OKAZAKI, Kazushi, OKAZAKI, Shuzo, NAKAMURA, Hideaki, KITAMURA, Yasuki, HATAYAMA, Kazuhisa, WAKABAYASHI, Sachiko, TSUDA, Toshiharu, KATSUMATA, Tomoyoshi, NISHIKAWA, Akiyoshi, HIROSE, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Blood Chemical Analysis Dose-Response Relationship, Drug Endocrine system Environmental pollutants toxicology Estrous Cycle - drug effects European Union Female General aspects Genistein - administration & dosage Genistein - toxicity Genitalia, Female - drug effects Genitalia, Female - pathology Genitalia, Female - physiopathology Genitalia, Male - drug effects Genitalia, Male - pathology Genitalia, Male - physiopathology Histopathology Hormone Antagonists - toxicity Male Medical sciences Motor Activity - drug effects No-Observed-Adverse-Effect Level Organ Size Prolactin - blood Rats Rats, Inbred Strains Rodents Spermatozoa - drug effects Spermatozoa - pathology Toxicity Toxicology
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