Dermal exposure to aqueous solutions of N-methyl pyrrolidone
N-methyl pyrrolidone (NMP) is a substance widely used for its strong and selective solvent capacity. The strong potential NMP has for skin absorption makes biological monitoring ideal for exposure assessment. This study looked at brief exposures to NMP in aqueous solutions over a range of concentrat...
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| Veröffentlicht in: | Toxicology letters 2002-08, Vol.134 (1), p.265-269 |
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| creator | Akrill, Peter Cocker, John Dixon, Steve |
| description | N-methyl pyrrolidone (NMP) is a substance widely used for its strong and selective solvent capacity. The strong potential NMP has for skin absorption makes biological monitoring ideal for exposure assessment. This study looked at brief exposures to NMP in aqueous solutions over a range of concentrations. Two volunteers placed one hand in NMP solutions ranging from 5 to 25% for as long as 15 min followed by urine collection for 48 h. The analyte of interest (analysed by GC-MS) was the NMP metabolite 5-hydroxy-
N-methyl pyrrolidone (5-HNMP). Excretion of 5-HNMP was plotted against time and this showed that urine concentrations were at a maximum after about 10 h and 5-HNMP excretion continued for 48 h after exposure. The half-life of excretion was found to be approximately 11 h. The mean correlation between exposure (as a measure of exposure duration and solution concentration) and total 5-HNMP excreted was 0.9297. |
| doi_str_mv | 10.1016/S0378-4274(02)00175-3 |
| format | Article |
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N-methyl pyrrolidone (5-HNMP). Excretion of 5-HNMP was plotted against time and this showed that urine concentrations were at a maximum after about 10 h and 5-HNMP excretion continued for 48 h after exposure. The half-life of excretion was found to be approximately 11 h. The mean correlation between exposure (as a measure of exposure duration and solution concentration) and total 5-HNMP excreted was 0.9297.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/S0378-4274(02)00175-3</identifier><identifier>PMID: 12191887</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Administration, Cutaneous ; Biological and medical sciences ; Biological monitoring ; Chemical and industrial products toxicology. Toxic occupational diseases ; Dermal exposure ; Dose-Response Relationship, Drug ; Environmental Monitoring - methods ; Gas Chromatography-Mass Spectrometry ; Half-Life ; Humans ; Medical sciences ; N-Methyl pyrrolidone ; Pyrrolidinones - administration & dosage ; Pyrrolidinones - pharmacokinetics ; Pyrrolidinones - urine ; Solvents ; Solvents - administration & dosage ; Solvents - pharmacokinetics ; Toxicology</subject><ispartof>Toxicology letters, 2002-08, Vol.134 (1), p.265-269</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-8974615ecb1c7d321b5d8a098e6743463376458c149963b4c41e51ff18c7deb53</citedby><cites>FETCH-LOGICAL-c422t-8974615ecb1c7d321b5d8a098e6743463376458c149963b4c41e51ff18c7deb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378427402001753$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13906270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12191887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akrill, Peter</creatorcontrib><creatorcontrib>Cocker, John</creatorcontrib><creatorcontrib>Dixon, Steve</creatorcontrib><title>Dermal exposure to aqueous solutions of N-methyl pyrrolidone</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>N-methyl pyrrolidone (NMP) is a substance widely used for its strong and selective solvent capacity. The strong potential NMP has for skin absorption makes biological monitoring ideal for exposure assessment. This study looked at brief exposures to NMP in aqueous solutions over a range of concentrations. Two volunteers placed one hand in NMP solutions ranging from 5 to 25% for as long as 15 min followed by urine collection for 48 h. The analyte of interest (analysed by GC-MS) was the NMP metabolite 5-hydroxy-
N-methyl pyrrolidone (5-HNMP). Excretion of 5-HNMP was plotted against time and this showed that urine concentrations were at a maximum after about 10 h and 5-HNMP excretion continued for 48 h after exposure. The half-life of excretion was found to be approximately 11 h. The mean correlation between exposure (as a measure of exposure duration and solution concentration) and total 5-HNMP excreted was 0.9297.</description><subject>Administration, Cutaneous</subject><subject>Biological and medical sciences</subject><subject>Biological monitoring</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Dermal exposure</subject><subject>Dose-Response Relationship, Drug</subject><subject>Environmental Monitoring - methods</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>N-Methyl pyrrolidone</subject><subject>Pyrrolidinones - administration & dosage</subject><subject>Pyrrolidinones - pharmacokinetics</subject><subject>Pyrrolidinones - urine</subject><subject>Solvents</subject><subject>Solvents - administration & dosage</subject><subject>Solvents - pharmacokinetics</subject><subject>Toxicology</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1P3DAQgGGrApVl259QlAuIHkI9tuMPCQkh2lIk1B6gZ8txJqpREi92grr_niy7giMnX54Zj15CvgA9Awry2x3lSpeCKXFK2VdKQVUl_0AWoJUpOUizRxav5IAc5vxAKZVCVh_JATAwoLVakPPvmHrXFfh_FfOUsBhj4R4njFMucuymMcQhF7Etfpc9jv_WXbFapxS70MQBP5H91nUZP-_eJfn788f91a_y9s_1zdXlbekFY2OpjRISKvQ1eNVwBnXVaEeNRqkEF5JzJUWlPQhjJK-FF4AVtC3omWNd8SU52e5dpTjflkfbh-yx69ywOdSCFkZxxWZYbaFPMeeErV2l0Lu0tkDtJpt9yWY3TSxl9iWb5fPc0e6Dqe6xeZvadZrB8Q647F3XJjf4kN8cN1QyRWd3sXU453gKmGz2AQePTUjoR9vE8M4pzw_hiFk</recordid><startdate>20020805</startdate><enddate>20020805</enddate><creator>Akrill, Peter</creator><creator>Cocker, John</creator><creator>Dixon, Steve</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20020805</creationdate><title>Dermal exposure to aqueous solutions of N-methyl pyrrolidone</title><author>Akrill, Peter ; Cocker, John ; Dixon, Steve</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-8974615ecb1c7d321b5d8a098e6743463376458c149963b4c41e51ff18c7deb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Cutaneous</topic><topic>Biological and medical sciences</topic><topic>Biological monitoring</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Dermal exposure</topic><topic>Dose-Response Relationship, Drug</topic><topic>Environmental Monitoring - methods</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>N-Methyl pyrrolidone</topic><topic>Pyrrolidinones - administration & dosage</topic><topic>Pyrrolidinones - pharmacokinetics</topic><topic>Pyrrolidinones - urine</topic><topic>Solvents</topic><topic>Solvents - administration & dosage</topic><topic>Solvents - pharmacokinetics</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akrill, Peter</creatorcontrib><creatorcontrib>Cocker, John</creatorcontrib><creatorcontrib>Dixon, Steve</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akrill, Peter</au><au>Cocker, John</au><au>Dixon, Steve</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dermal exposure to aqueous solutions of N-methyl pyrrolidone</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2002-08-05</date><risdate>2002</risdate><volume>134</volume><issue>1</issue><spage>265</spage><epage>269</epage><pages>265-269</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>N-methyl pyrrolidone (NMP) is a substance widely used for its strong and selective solvent capacity. The strong potential NMP has for skin absorption makes biological monitoring ideal for exposure assessment. This study looked at brief exposures to NMP in aqueous solutions over a range of concentrations. Two volunteers placed one hand in NMP solutions ranging from 5 to 25% for as long as 15 min followed by urine collection for 48 h. The analyte of interest (analysed by GC-MS) was the NMP metabolite 5-hydroxy-
N-methyl pyrrolidone (5-HNMP). Excretion of 5-HNMP was plotted against time and this showed that urine concentrations were at a maximum after about 10 h and 5-HNMP excretion continued for 48 h after exposure. The half-life of excretion was found to be approximately 11 h. The mean correlation between exposure (as a measure of exposure duration and solution concentration) and total 5-HNMP excreted was 0.9297.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>12191887</pmid><doi>10.1016/S0378-4274(02)00175-3</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 2002-08, Vol.134 (1), p.265-269 |
| issn | 0378-4274 1879-3169 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Cutaneous Biological and medical sciences Biological monitoring Chemical and industrial products toxicology. Toxic occupational diseases Dermal exposure Dose-Response Relationship, Drug Environmental Monitoring - methods Gas Chromatography-Mass Spectrometry Half-Life Humans Medical sciences N-Methyl pyrrolidone Pyrrolidinones - administration & dosage Pyrrolidinones - pharmacokinetics Pyrrolidinones - urine Solvents Solvents - administration & dosage Solvents - pharmacokinetics Toxicology |
| title | Dermal exposure to aqueous solutions of N-methyl pyrrolidone |
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