Structure−Activity Relationships in 4-Aminoquinoline Antiplasmodials. The Role of the Group at the 7-Position

Antiplasmodial activities versus the chloroquine sensitive D10 strain of Plasmodium falciparum of a series of N ,N 1-diethyl-N -(4-quinolinyl)-1,2-ethanediamines with 11 different substituents at the 7-position on the quinoline ring have been investigated in vitro. Electron-withdrawing groups at the...

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