Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2[alpha]

Hypoxia profoundly influences tumor development and response to therapy. While progress has been made in identifying individual gene products whose synthesis is altered under hypoxia, little is known about the mechanism by which hypoxia induces a global downregulation of protein synthesis. A critica...

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Veröffentlicht in:	Molecular and cellular biology 2002-11, Vol.22 (21), p.7405-7416
Hauptverfasser:	Koumenis, C, Naczki, C, Koritzinsky, M, Rastani, S, Diehl, A, Sonenberg, N, Koromilas, A, Wouters, B G
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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