Exposure to exogenous 17β-oestradiol disrupts P450aromB mRNA expression in the brain and gonad of adult fathead minnows ( Pimephales promelas)

Oestrogens are key regulators in sexual differentiation and development in higher vertebrates. P450 aromatase (P450arom) is the steroidogenic enzyme responsible for the synthesis of oestrogens from aromatisable androgens. Effects of endocrine disrupting chemicals on steroidogenic enzyme gene express...

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Veröffentlicht in:	Aquatic toxicology 2002-10, Vol.60 (3), p.285-299
Hauptverfasser:	Halm, S, Pounds, N, Maddix, S, Rand-Weaver, M, Sumpter, J.P, Hutchinson, T.H, Tyler, C.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Agnatha. Pisces Animal, plant and microbial ecology Applied ecology Aromatase Biological and medical sciences Brain Competitive-RT-PCR double prime P450 aromatase Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Endocrine disruption Fundamental and applied biological sciences. Psychology Gene expression Gonads In vivo Medical sciences Pesticides, fertilizers and other agrochemicals toxicology Pimephales promelas sexual development Toxicology
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