Oxidant-induced Vascular Endothelial Growth Factor Expression in Human Keratinocytes and Cutaneous Wound Healing

Neutrophils and macrophages, recruited to the wound site, release reactive oxygen species by respiratory burst. It is commonly understood that oxidants serve mainly to kill bacteria and prevent wound infection. We tested the hypothesis that oxidants generated at the wound site promote dermal wound r...

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Veröffentlicht in:	The Journal of biological chemistry 2002-09, Vol.277 (36), p.33284-33290
Hauptverfasser:	Sen, Chandan K., Khanna, Savita, Babior, Bernard M., Hunt, Thomas K., Ellison, E. Christopher, Roy, Sashwati
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Collagen - metabolism Endothelial Growth Factors - metabolism Gene Deletion Gene Transfer Techniques Green Fluorescent Proteins Humans Hydrogen Peroxide - pharmacology Immunoblotting Keratinocytes - metabolism Luciferases - metabolism Luminescent Proteins - metabolism Lymphokines - metabolism Male Mice Mice, Inbred BALB C Microscopy, Fluorescence NADPH Oxidases - metabolism Neovascularization, Pathologic Oxidants - pharmacology Oxidation-Reduction Phosphotyrosine - metabolism Plasmids - metabolism Precipitin Tests Promoter Regions, Genetic rac1 GTP-Binding Protein - metabolism Reverse Transcriptase Polymerase Chain Reaction Ribonucleases - metabolism Skin - pathology Skin Physiological Phenomena Time Factors Transcriptional Activation Transfection Tumor Cells, Cultured Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Wound Healing
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