Blood Concentration of Milnacipran in a Case of a Fatal Automobile Accident

A fatal automobile accident involving milnacipran and ethyl alcohol is reported. The drug was identified and quantitated in blood by high-performance liquid chromatography-diode-array detection. The concentration of milnacipran in peripheral blood was 3.15 µg/mL exceeded 10.5 times the therapeutic c...

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Veröffentlicht in:	Journal of analytical toxicology 2002-03, Vol.26 (2), p.123-126
Hauptverfasser:	Rop, Pok P., Sournac, Marie H., Burle, Joelle, Fornaris, Monique, Coiffait, Philippe E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accidents, Traffic Adult Alcohol Drinking - adverse effects Analysis Antidepressive Agents - adverse effects Antidepressive Agents - blood Biological and medical sciences Chromatography, High Pressure Liquid Cyclopropanes - adverse effects Cyclopropanes - blood Drug Interactions Ethanol - adverse effects Ethanol - blood Fatal Outcome Female Forensic Medicine - methods General pharmacology Humans Medical sciences Milnacipran Pharmacology. Drug treatments Substance Abuse Detection - methods
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Beschreibung
Zusammenfassung:	A fatal automobile accident involving milnacipran and ethyl alcohol is reported. The drug was identified and quantitated in blood by high-performance liquid chromatography-diode-array detection. The concentration of milnacipran in peripheral blood was 3.15 µg/mL exceeded 10.5 times the therapeutic concentration. The blood ethyl alcohol level was 1.3 g/L.
ISSN:	0146-4760 1945-2403
DOI:	10.1093/jat/26.2.123