Induction of Cyclooxygenase-2 in a Mouse Model of Peutz-Jeghers Polyposis

Inactivating germ-line mutations of LKB1 lead to Peutz-Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe gastrointestinal polyposis. In all cases, the polyps arising in the Lkb1+/-mice were found to be hamartomas...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-09, Vol.99 (19), p.12327-12332
Hauptverfasser:	Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, Henkemeyer, Mark, Ristimäki, Ari, Aaltonen, Lauri A., Mäkelä, Tomi P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Alleles AMP-Activated Protein Kinases Animals Biological Sciences Carrier Proteins Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Disease Disease Models, Animal Endothelial Growth Factors - metabolism Enzyme Induction Enzymes Genes, Tumor Suppressor Hamartoma Heterozygote Histology Humans In situ hybridization Inductive reasoning Intracellular Signaling Peptides and Proteins Isoenzymes - biosynthesis Loss of heterozygosity Lymphokines - metabolism Membrane Proteins Mice Mice, Knockout Mutation Peutz-Jeghers Syndrome - drug therapy Peutz-Jeghers Syndrome - enzymology Peutz-Jeghers Syndrome - genetics Peutz-Jeghers Syndrome - pathology Polymerase chain reaction Prostaglandin-Endoperoxide Synthases - biosynthesis Protein Serine-Threonine Kinases - deficiency Protein Serine-Threonine Kinases - genetics Signal Transduction Stomach Tumors Up-Regulation Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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