Using Mechanical Force to Probe the Mechanism of Pausing and Arrest during Continuous Elongation by Escherichia coli RNA Polymerase

Escherichia coli RNA polymerase translocates along the DNA discontinuously during the elongation phase of transcription, spending proportionally more time at some template positions, known as pause and arrest sites, than at others. Current models of elongation suggest that the enzyme backtracks at t...

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