Effect of vitamin D on biochemical parameters in polycystic ovary syndrome women: a meta-analysis
Aim To investigate the therapeutical effect of vitamin D supplementation on the metabolism and endocrine parameters of PCOS patients. Materials and methods Clinical studies investigating the therapeutic effect of vitamin D supplementation on PCOS patients were selected by searching PubMed, Embase, T...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2017-02, Vol.295 (2), p.487-496 |
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| container_title | Archives of gynecology and obstetrics |
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| creator | Xue, Yunping Xu, Pengfei Xue, Kai Duan, Xiaoyi Cao, Jian Luan, Ting Li, Qian Gu, Lin |
| description | Aim
To investigate the therapeutical effect of vitamin D supplementation on the metabolism and endocrine parameters of PCOS patients.
Materials and methods
Clinical studies investigating the therapeutic effect of vitamin D supplementation on PCOS patients were selected by searching PubMed, Embase, The Cochrane library and Web of Science until April 2016. The included articles were selected according to the inclusion criteria. Serum HOMA-IR, QUICKI, LDL, DHEAS, free testosterone (FT), total testosterone (TT), PTH, 25-hydroxy-vitamin D, and triglyceride of PCOS patients were enrolled for evaluating the therapeutic effects of vitamin D.
Results
16 studies were included in this study. There was no significant difference between the placebo group and vitamin D group in the concentration of serum 25-hydroxy-vitamin D in patients with PCOS (
P
= 0.06). After treated with vitamin D, the serum 25-hydroxy-vitamin D in PCOS patients was increased (
P
|
| doi_str_mv | 10.1007/s00404-016-4247-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1847894113</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2261528861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-e46c0669079fab51ddfc5b74822e65a6db3aa32acfbda5b018d74e1fe25fd21c3</originalsourceid><addsrcrecordid>eNp1kMFO3DAQhq2KqmyhD8AFWeLSS1qP7dgJN7TdQiWkXsrZmjh2CUrixU5Aeft6tQtISL14LM03vz0fIWfAvgFj-ntiTDJZMFCF5FIXyweyAil4wTTAEVmxendnSh-Tzyk9MAa8qtQncsx1LYSo9IrgxntnJxo8feomHLqR_qBhpE0X7L0bOos93WLEwU0uJprb29AvdklTZ2l4wrjQtIxtDIOjz_kYLynSDGOBI_ZL6tIp-eixT-7LoZ6Qu5-bP-ub4vb39a_11W1hheZT4aSyTKma6dpjU0Lbels2WlacO1WiahuBKDha37RYNgyqVksH3vHStxysOCFf97nbGB5nlyYzdMm6vsfRhTkZqKSuagkgMnrxDn0Ic8z_TYZzBeXOEmQK9pSNIaXovNnGbsgbG2Bm59_s_Zvs3-z8myXPnB-S52Zw7evEi_AM8D2Qcmv86-Lb0_9P_QcqDZG8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261528861</pqid></control><display><type>article</type><title>Effect of vitamin D on biochemical parameters in polycystic ovary syndrome women: a meta-analysis</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Xue, Yunping ; Xu, Pengfei ; Xue, Kai ; Duan, Xiaoyi ; Cao, Jian ; Luan, Ting ; Li, Qian ; Gu, Lin</creator><creatorcontrib>Xue, Yunping ; Xu, Pengfei ; Xue, Kai ; Duan, Xiaoyi ; Cao, Jian ; Luan, Ting ; Li, Qian ; Gu, Lin</creatorcontrib><description>Aim
To investigate the therapeutical effect of vitamin D supplementation on the metabolism and endocrine parameters of PCOS patients.
Materials and methods
Clinical studies investigating the therapeutic effect of vitamin D supplementation on PCOS patients were selected by searching PubMed, Embase, The Cochrane library and Web of Science until April 2016. The included articles were selected according to the inclusion criteria. Serum HOMA-IR, QUICKI, LDL, DHEAS, free testosterone (FT), total testosterone (TT), PTH, 25-hydroxy-vitamin D, and triglyceride of PCOS patients were enrolled for evaluating the therapeutic effects of vitamin D.
Results
16 studies were included in this study. There was no significant difference between the placebo group and vitamin D group in the concentration of serum 25-hydroxy-vitamin D in patients with PCOS (
P
= 0.06). After treated with vitamin D, the serum 25-hydroxy-vitamin D in PCOS patients was increased (
P
< 0.00001), while the serum PTH (
P
= 0.003) and triglyceride (
P
= 0.006) were decreased. In addition, the serum HOMA-IR, QUICKI, LDL, DHEAS, FT, and TT in PCOS patients did not change. Subgroup analysis showed that the serum triglyceride of PCOS patients was decreased by low dose of vitamin D supplementation (<50,000 IU) (
P
= 0.03), but no significantly changed by high-dose vitamin D supplementation (≥50,000 IU) (
P
= 0.17).
Conclusion
Vitamin D supplementation significantly attenuates serum PTH and triglyceride in PCOS patients except for serum HOMA-IR, QUICKI, LDL, DHEAS, FT, and TT. Furthermore, less than 50,000 IU vitamin D supplementation is sufficient for decreasing serum triglyceride.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-016-4247-y</identifier><identifier>PMID: 27933387</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Dietary Supplements ; Endocrinology ; Female ; Gynecologic Endocrinology and Reproductive Medicine ; Gynecology ; Human Genetics ; Humans ; Medicine ; Medicine & Public Health ; Meta-analysis ; Obstetrics/Perinatology/Midwifery ; Parathyroid Hormone - blood ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Testosterone - blood ; Triglycerides - blood ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>Archives of gynecology and obstetrics, 2017-02, Vol.295 (2), p.487-496</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2016). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-e46c0669079fab51ddfc5b74822e65a6db3aa32acfbda5b018d74e1fe25fd21c3</citedby><cites>FETCH-LOGICAL-c372t-e46c0669079fab51ddfc5b74822e65a6db3aa32acfbda5b018d74e1fe25fd21c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-016-4247-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-016-4247-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27933387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Yunping</creatorcontrib><creatorcontrib>Xu, Pengfei</creatorcontrib><creatorcontrib>Xue, Kai</creatorcontrib><creatorcontrib>Duan, Xiaoyi</creatorcontrib><creatorcontrib>Cao, Jian</creatorcontrib><creatorcontrib>Luan, Ting</creatorcontrib><creatorcontrib>Li, Qian</creatorcontrib><creatorcontrib>Gu, Lin</creatorcontrib><title>Effect of vitamin D on biochemical parameters in polycystic ovary syndrome women: a meta-analysis</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Aim
To investigate the therapeutical effect of vitamin D supplementation on the metabolism and endocrine parameters of PCOS patients.
Materials and methods
Clinical studies investigating the therapeutic effect of vitamin D supplementation on PCOS patients were selected by searching PubMed, Embase, The Cochrane library and Web of Science until April 2016. The included articles were selected according to the inclusion criteria. Serum HOMA-IR, QUICKI, LDL, DHEAS, free testosterone (FT), total testosterone (TT), PTH, 25-hydroxy-vitamin D, and triglyceride of PCOS patients were enrolled for evaluating the therapeutic effects of vitamin D.
Results
16 studies were included in this study. There was no significant difference between the placebo group and vitamin D group in the concentration of serum 25-hydroxy-vitamin D in patients with PCOS (
P
= 0.06). After treated with vitamin D, the serum 25-hydroxy-vitamin D in PCOS patients was increased (
P
< 0.00001), while the serum PTH (
P
= 0.003) and triglyceride (
P
= 0.006) were decreased. In addition, the serum HOMA-IR, QUICKI, LDL, DHEAS, FT, and TT in PCOS patients did not change. Subgroup analysis showed that the serum triglyceride of PCOS patients was decreased by low dose of vitamin D supplementation (<50,000 IU) (
P
= 0.03), but no significantly changed by high-dose vitamin D supplementation (≥50,000 IU) (
P
= 0.17).
Conclusion
Vitamin D supplementation significantly attenuates serum PTH and triglyceride in PCOS patients except for serum HOMA-IR, QUICKI, LDL, DHEAS, FT, and TT. Furthermore, less than 50,000 IU vitamin D supplementation is sufficient for decreasing serum triglyceride.</description><subject>Dietary Supplements</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Gynecologic Endocrinology and Reproductive Medicine</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Parathyroid Hormone - blood</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Testosterone - blood</subject><subject>Triglycerides - blood</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kMFO3DAQhq2KqmyhD8AFWeLSS1qP7dgJN7TdQiWkXsrZmjh2CUrixU5Aeft6tQtISL14LM03vz0fIWfAvgFj-ntiTDJZMFCF5FIXyweyAil4wTTAEVmxendnSh-Tzyk9MAa8qtQncsx1LYSo9IrgxntnJxo8feomHLqR_qBhpE0X7L0bOos93WLEwU0uJprb29AvdklTZ2l4wrjQtIxtDIOjz_kYLynSDGOBI_ZL6tIp-eixT-7LoZ6Qu5-bP-ub4vb39a_11W1hheZT4aSyTKma6dpjU0Lbels2WlacO1WiahuBKDha37RYNgyqVksH3vHStxysOCFf97nbGB5nlyYzdMm6vsfRhTkZqKSuagkgMnrxDn0Ic8z_TYZzBeXOEmQK9pSNIaXovNnGbsgbG2Bm59_s_Zvs3-z8myXPnB-S52Zw7evEi_AM8D2Qcmv86-Lb0_9P_QcqDZG8</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Xue, Yunping</creator><creator>Xu, Pengfei</creator><creator>Xue, Kai</creator><creator>Duan, Xiaoyi</creator><creator>Cao, Jian</creator><creator>Luan, Ting</creator><creator>Li, Qian</creator><creator>Gu, Lin</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>Effect of vitamin D on biochemical parameters in polycystic ovary syndrome women: a meta-analysis</title><author>Xue, Yunping ; Xu, Pengfei ; Xue, Kai ; Duan, Xiaoyi ; Cao, Jian ; Luan, Ting ; Li, Qian ; Gu, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-e46c0669079fab51ddfc5b74822e65a6db3aa32acfbda5b018d74e1fe25fd21c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Dietary Supplements</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Gynecologic Endocrinology and Reproductive Medicine</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Parathyroid Hormone - blood</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Testosterone - blood</topic><topic>Triglycerides - blood</topic><topic>Vitamin D</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xue, Yunping</creatorcontrib><creatorcontrib>Xu, Pengfei</creatorcontrib><creatorcontrib>Xue, Kai</creatorcontrib><creatorcontrib>Duan, Xiaoyi</creatorcontrib><creatorcontrib>Cao, Jian</creatorcontrib><creatorcontrib>Luan, Ting</creatorcontrib><creatorcontrib>Li, Qian</creatorcontrib><creatorcontrib>Gu, Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xue, Yunping</au><au>Xu, Pengfei</au><au>Xue, Kai</au><au>Duan, Xiaoyi</au><au>Cao, Jian</au><au>Luan, Ting</au><au>Li, Qian</au><au>Gu, Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vitamin D on biochemical parameters in polycystic ovary syndrome women: a meta-analysis</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>295</volume><issue>2</issue><spage>487</spage><epage>496</epage><pages>487-496</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Aim
To investigate the therapeutical effect of vitamin D supplementation on the metabolism and endocrine parameters of PCOS patients.
Materials and methods
Clinical studies investigating the therapeutic effect of vitamin D supplementation on PCOS patients were selected by searching PubMed, Embase, The Cochrane library and Web of Science until April 2016. The included articles were selected according to the inclusion criteria. Serum HOMA-IR, QUICKI, LDL, DHEAS, free testosterone (FT), total testosterone (TT), PTH, 25-hydroxy-vitamin D, and triglyceride of PCOS patients were enrolled for evaluating the therapeutic effects of vitamin D.
Results
16 studies were included in this study. There was no significant difference between the placebo group and vitamin D group in the concentration of serum 25-hydroxy-vitamin D in patients with PCOS (
P
= 0.06). After treated with vitamin D, the serum 25-hydroxy-vitamin D in PCOS patients was increased (
P
< 0.00001), while the serum PTH (
P
= 0.003) and triglyceride (
P
= 0.006) were decreased. In addition, the serum HOMA-IR, QUICKI, LDL, DHEAS, FT, and TT in PCOS patients did not change. Subgroup analysis showed that the serum triglyceride of PCOS patients was decreased by low dose of vitamin D supplementation (<50,000 IU) (
P
= 0.03), but no significantly changed by high-dose vitamin D supplementation (≥50,000 IU) (
P
= 0.17).
Conclusion
Vitamin D supplementation significantly attenuates serum PTH and triglyceride in PCOS patients except for serum HOMA-IR, QUICKI, LDL, DHEAS, FT, and TT. Furthermore, less than 50,000 IU vitamin D supplementation is sufficient for decreasing serum triglyceride.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27933387</pmid><doi>10.1007/s00404-016-4247-y</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2017-02, Vol.295 (2), p.487-496 |
| issn | 0932-0067 1432-0711 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Dietary Supplements Endocrinology Female Gynecologic Endocrinology and Reproductive Medicine Gynecology Human Genetics Humans Medicine Medicine & Public Health Meta-analysis Obstetrics/Perinatology/Midwifery Parathyroid Hormone - blood Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Testosterone - blood Triglycerides - blood Vitamin D Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Effect of vitamin D on biochemical parameters in polycystic ovary syndrome women: a meta-analysis |
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