Potent Inhibition of 3‑Deoxy‑d‑arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic

3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) synthase catalyzes the first step in the shikimate pathway. It catalyzes an aldol-like reaction of phosphoenolpyruvate (PEP) with erythrose 4-phosphate (E4P) to form DAHP. The kinetic mechanism was rapid equilibrium sequential ordered ter ter, with t...

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Veröffentlicht in:	Biochemistry (Easton) 2016-12, Vol.55 (48), p.6617-6629
Hauptverfasser:	Balachandran, Naresh, Heimhalt, Maren, Liuni, Peter, To, Frederick, Wilson, Derek J, Junop, Murray S, Berti, Paul J
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Deoxy-7-Phosphoheptulonate Synthase - antagonists & inhibitors 3-Deoxy-7-Phosphoheptulonate Synthase - chemistry 3-Deoxy-7-Phosphoheptulonate Synthase - metabolism Algorithms Biocatalysis - drug effects Crystallography, X-Ray Deuterium Exchange Measurement Escherichia coli - enzymology Escherichia coli Proteins - antagonists & inhibitors Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Kinetics Models, Molecular Molecular Structure Oximes - chemistry Oximes - pharmacology Protein Binding Protein Domains Protein Multimerization Sugar Acids - chemistry Sugar Acids - pharmacology
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