Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Chinese hamster ovary (CHO) cells are the preferred cell factory for the production of therapeutic glycoproteins. Although efforts primarily within bioprocess optimization have led to increased product titers of recombinant proteins (r-proteins) expressed in CHO cells, post-transcriptional bottlenec...

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Veröffentlicht in:Biotechnology advances 2017-01, Vol.35 (1), p.64-76
Hauptverfasser: Hansen, Henning Gram, Pristovšek, Nuša, Kildegaard, Helene Faustrup, Lee, Gyun Min
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Sprache:eng
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