Case Report Demonstrating the Safe and Effective Means of Expanding the Donor Pool With Livers Recovered From Brain-Dead Donors After Ethylene Glycol Toxicity
Abstract The growing disparity between organ supply and demand has become the greatest hurdle facing transplant professionals and life-saving transplants. Because the organ shortage has become the rate-limiting step to effective transplants, it is critical for the transplant community to identify vi...
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Veröffentlicht in: | Transplantation proceedings 2016-11, Vol.48 (9), p.3064-3066 |
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creator | Fujii, M.H Gierlach, J Alami, S Ericksen, C Kashyap, R Orloff, M.S Marroquin, C.E |
description | Abstract The growing disparity between organ supply and demand has become the greatest hurdle facing transplant professionals and life-saving transplants. Because the organ shortage has become the rate-limiting step to effective transplants, it is critical for the transplant community to identify viable mechanisms to expand the donor pool and use every available allograft. Although using kidneys from deceased donors whose demise was secondary to ethylene glycol (EG) toxicity requires great deliberation and precise timing as described by Barbas et al [5] , using hepatic allografts in this setting involves far less risk. The following is a discussion of a 61-year-old male who was diagnosed with end-stage liver disease secondary to non-alcoholic steatohepatitis and ultimately underwent a life-saving transplant with a liver recovered from a donor with EG-induced brain death and allocated nationally due to trepidation by local and regional centers to use the liver from a donor after EG toxicity. |
doi_str_mv | 10.1016/j.transproceed.2016.04.003 |
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Because the organ shortage has become the rate-limiting step to effective transplants, it is critical for the transplant community to identify viable mechanisms to expand the donor pool and use every available allograft. Although using kidneys from deceased donors whose demise was secondary to ethylene glycol (EG) toxicity requires great deliberation and precise timing as described by Barbas et al [5] , using hepatic allografts in this setting involves far less risk. The following is a discussion of a 61-year-old male who was diagnosed with end-stage liver disease secondary to non-alcoholic steatohepatitis and ultimately underwent a life-saving transplant with a liver recovered from a donor with EG-induced brain death and allocated nationally due to trepidation by local and regional centers to use the liver from a donor after EG toxicity.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2016.04.003</identifier><identifier>PMID: 27932147</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Brain Death ; End Stage Liver Disease - surgery ; Ethylene Glycol - poisoning ; Humans ; Liver Transplantation - methods ; Male ; Middle Aged ; Suicide ; Surgery ; Tissue and Organ Procurement - methods ; Tissue Donors - supply & distribution ; Transplantation, Homologous - methods ; Transplants - physiology</subject><ispartof>Transplantation proceedings, 2016-11, Vol.48 (9), p.3064-3066</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. 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The following is a discussion of a 61-year-old male who was diagnosed with end-stage liver disease secondary to non-alcoholic steatohepatitis and ultimately underwent a life-saving transplant with a liver recovered from a donor with EG-induced brain death and allocated nationally due to trepidation by local and regional centers to use the liver from a donor after EG toxicity.</description><subject>Adult</subject><subject>Brain Death</subject><subject>End Stage Liver Disease - surgery</subject><subject>Ethylene Glycol - poisoning</subject><subject>Humans</subject><subject>Liver Transplantation - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Suicide</subject><subject>Surgery</subject><subject>Tissue and Organ Procurement - methods</subject><subject>Tissue Donors - supply & distribution</subject><subject>Transplantation, Homologous - methods</subject><subject>Transplants - physiology</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUstuEzEUHSEQDYVfQBYrNjP1a14skEqStkhBIFrE0vLY18RhYgfbqTo_w7fiKI2EWLHx656HfM8tijcEVwST5mJTpSBd3AWvAHRF81uFeYUxe1LMSNeykjaUPS1mGHNSEsbrs-JFjBuc75Sz58UZbXtGCW9nxe-5jIC-ws6HhBaw9S5m8WTdD5TWgG6lASSdRktjQCV7D-gTZG_kDVo-7HLlhFx45wP64v2Ivtu0RquMDTErK58PoNFV8Fv0IUjrygVIfSREdGkSBLRM62kEB-h6nFSWuPMPVtk0vSyeGTlGePW4nxffrpZ385ty9fn64_xyVSrO6lSatqENZu3Q9nrQimDTDZLLltMOamr6vHBqADcdpn1NqWRMD3VLa15r1TWanRdvj7q5qb_2EJPY2qhgHKUDv4-CdLztur7jdYa-O0JV8DEGMGIX7FaGSRAsDvmIjfg7H3HIR2Aucj6Z_PrRZz9sc-1EPQWSAYsjAPJv7y0EEZUFp0DbkAMQ2tv_83n_j4warbNKjj9hgrjx--ByPwURkQosbg-TchgU0jBMGKHsDy1UvlY</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Fujii, M.H</creator><creator>Gierlach, J</creator><creator>Alami, S</creator><creator>Ericksen, C</creator><creator>Kashyap, R</creator><creator>Orloff, M.S</creator><creator>Marroquin, C.E</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Case Report Demonstrating the Safe and Effective Means of Expanding the Donor Pool With Livers Recovered From Brain-Dead Donors After Ethylene Glycol Toxicity</title><author>Fujii, M.H ; Gierlach, J ; Alami, S ; Ericksen, C ; Kashyap, R ; Orloff, M.S ; Marroquin, C.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-f7626037b79dbdc10f8ba4a7428e52f9e5242fe068029522a33db572545dc86d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Brain Death</topic><topic>End Stage Liver Disease - surgery</topic><topic>Ethylene Glycol - poisoning</topic><topic>Humans</topic><topic>Liver Transplantation - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Suicide</topic><topic>Surgery</topic><topic>Tissue and Organ Procurement - methods</topic><topic>Tissue Donors - supply & distribution</topic><topic>Transplantation, Homologous - methods</topic><topic>Transplants - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujii, M.H</creatorcontrib><creatorcontrib>Gierlach, J</creatorcontrib><creatorcontrib>Alami, S</creatorcontrib><creatorcontrib>Ericksen, C</creatorcontrib><creatorcontrib>Kashyap, R</creatorcontrib><creatorcontrib>Orloff, M.S</creatorcontrib><creatorcontrib>Marroquin, C.E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujii, M.H</au><au>Gierlach, J</au><au>Alami, S</au><au>Ericksen, C</au><au>Kashyap, R</au><au>Orloff, M.S</au><au>Marroquin, C.E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Case Report Demonstrating the Safe and Effective Means of Expanding the Donor Pool With Livers Recovered From Brain-Dead Donors After Ethylene Glycol Toxicity</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>48</volume><issue>9</issue><spage>3064</spage><epage>3066</epage><pages>3064-3066</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><abstract>Abstract The growing disparity between organ supply and demand has become the greatest hurdle facing transplant professionals and life-saving transplants. Because the organ shortage has become the rate-limiting step to effective transplants, it is critical for the transplant community to identify viable mechanisms to expand the donor pool and use every available allograft. Although using kidneys from deceased donors whose demise was secondary to ethylene glycol (EG) toxicity requires great deliberation and precise timing as described by Barbas et al [5] , using hepatic allografts in this setting involves far less risk. 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subjects | Adult Brain Death End Stage Liver Disease - surgery Ethylene Glycol - poisoning Humans Liver Transplantation - methods Male Middle Aged Suicide Surgery Tissue and Organ Procurement - methods Tissue Donors - supply & distribution Transplantation, Homologous - methods Transplants - physiology |
title | Case Report Demonstrating the Safe and Effective Means of Expanding the Donor Pool With Livers Recovered From Brain-Dead Donors After Ethylene Glycol Toxicity |
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