Plazomicin is effective in a non-human primate pneumonic plague model

[Display omitted] The efficacy of plazomicin for pneumonic plague was evaluated in a non-human primate model. African Green monkeys challenged with a lethal aerosol of Yersinia pestis [median (range) of 98 (15–331) LD50s] received placebo (n=12) or ‘humanized’ dose regimens (6.25, 12.5 or 25mg/kg ev...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2016-12, Vol.24 (24), p.6429-6439
Hauptverfasser:	Mega, William M., Doyle-Eisele, Melanie, Cass, Robert T., Kostrub, Corwin F., Sherwood, Robert L., Metz, Matthew A., Cirz, Ryan T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycoside Animal rule Animals Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Molecular Conformation Plague Plague - drug therapy Plazomicin Pneumonia Sisomicin - analogs & derivatives Sisomicin - chemistry Sisomicin - therapeutic use Yersinia pestis
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