Urinary Beta-2Microglobulin: An Indicator of Renal Tubular Damage after Extracorporeal Shock Wave Lithotripsy
This study aims to determine extracorporeal shock wave lithotripsy (ESWL)-induced renal tubular damageand the affecting factors by measuring urinary beta2microglobulin (β2M) excretion. This is a cross-sectional study conducted on 91 patients with renal stones who underwentESWL during 2012. Urinary b...
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| Veröffentlicht in: | Urology journal 2016-12, Vol.13 (6), p.2911-2915 |
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| creator | Nasseh, Hamidreza Abdi, Sepideh Roshani, Ali Kazemnezhad, Ehsan |
| description | This study aims to determine extracorporeal shock wave lithotripsy (ESWL)-induced renal tubular damageand the affecting factors by measuring urinary beta2microglobulin (β2M) excretion.
This is a cross-sectional study conducted on 91 patients with renal stones who underwentESWL during 2012. Urinary beta2microglobulin was measured immediately before and after the procedure foreach patient and analyzed based on different variables to evaluate factors affecting ESWL-induced renal tubularinjury.
Mean ± SD urinary beta2-microglobulin values, before and after ESWL were 0.08 ± 0.07 and 0.22 ± 0.71mg/dL respectively, the average difference between which was equal to 0.14 ± 0.07 mg/dL. These figures exhibiteda 166.66% rise in the urinary β2M concentration after ESWL which was statistically significant (P < .001). Multivariateanalysis showed that hypertension (P = .05) and the history of ESWL (P = .02) were predictive factors ofhigher post-ESWL urinary beta2-microglobulin excretion.
Urinary excretion of beta2-microglobulin increased significantly immediately after ESWL. Thesechanges could indicate that ESWL is a contributing factor to renal tubular damage. It also seems that in patientswith hypertension and a previous history of ESWL the likelihood of this injury is higher than others. |
| doi_str_mv | 10.22037/UJ.V13I6.3624 |
| format | Article |
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This is a cross-sectional study conducted on 91 patients with renal stones who underwentESWL during 2012. Urinary beta2microglobulin was measured immediately before and after the procedure foreach patient and analyzed based on different variables to evaluate factors affecting ESWL-induced renal tubularinjury.
Mean ± SD urinary beta2-microglobulin values, before and after ESWL were 0.08 ± 0.07 and 0.22 ± 0.71mg/dL respectively, the average difference between which was equal to 0.14 ± 0.07 mg/dL. These figures exhibiteda 166.66% rise in the urinary β2M concentration after ESWL which was statistically significant (P < .001). Multivariateanalysis showed that hypertension (P = .05) and the history of ESWL (P = .02) were predictive factors ofhigher post-ESWL urinary beta2-microglobulin excretion.
Urinary excretion of beta2-microglobulin increased significantly immediately after ESWL. Thesechanges could indicate that ESWL is a contributing factor to renal tubular damage. It also seems that in patientswith hypertension and a previous history of ESWL the likelihood of this injury is higher than others.</description><identifier>ISSN: 1735-1308</identifier><identifier>EISSN: 1735-546X</identifier><identifier>DOI: 10.22037/UJ.V13I6.3624</identifier><identifier>PMID: 27928813</identifier><language>eng</language><publisher>Iran: Urology and Nephrology Research Center</publisher><subject>beta 2-Microglobulin - urine ; Cross-Sectional Studies ; Female ; Humans ; Hypertension ; Kidney Calculi - therapy ; Kidney Tubules - injuries ; Lithotripsy ; Lithotripsy - adverse effects ; Male ; Middle Aged</subject><ispartof>Urology journal, 2016-12, Vol.13 (6), p.2911-2915</ispartof><rights>Copyright Urology and Nephrology Research Center Nov-Dec 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27928813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nasseh, Hamidreza</creatorcontrib><creatorcontrib>Abdi, Sepideh</creatorcontrib><creatorcontrib>Roshani, Ali</creatorcontrib><creatorcontrib>Kazemnezhad, Ehsan</creatorcontrib><title>Urinary Beta-2Microglobulin: An Indicator of Renal Tubular Damage after Extracorporeal Shock Wave Lithotripsy</title><title>Urology journal</title><addtitle>Urol J</addtitle><description>This study aims to determine extracorporeal shock wave lithotripsy (ESWL)-induced renal tubular damageand the affecting factors by measuring urinary beta2microglobulin (β2M) excretion.
This is a cross-sectional study conducted on 91 patients with renal stones who underwentESWL during 2012. Urinary beta2microglobulin was measured immediately before and after the procedure foreach patient and analyzed based on different variables to evaluate factors affecting ESWL-induced renal tubularinjury.
Mean ± SD urinary beta2-microglobulin values, before and after ESWL were 0.08 ± 0.07 and 0.22 ± 0.71mg/dL respectively, the average difference between which was equal to 0.14 ± 0.07 mg/dL. These figures exhibiteda 166.66% rise in the urinary β2M concentration after ESWL which was statistically significant (P < .001). Multivariateanalysis showed that hypertension (P = .05) and the history of ESWL (P = .02) were predictive factors ofhigher post-ESWL urinary beta2-microglobulin excretion.
Urinary excretion of beta2-microglobulin increased significantly immediately after ESWL. Thesechanges could indicate that ESWL is a contributing factor to renal tubular damage. It also seems that in patientswith hypertension and a previous history of ESWL the likelihood of this injury is higher than others.</description><subject>beta 2-Microglobulin - urine</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Kidney Calculi - therapy</subject><subject>Kidney Tubules - injuries</subject><subject>Lithotripsy</subject><subject>Lithotripsy - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><issn>1735-1308</issn><issn>1735-546X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0D1PwzAQBmALgWgprIzIEgtLSmzHX2ylFCgqQoIW2CrHcVqXJA6Og-i_JxJlYbo73aOT7gXgFMVDjGPCLxcPw1dEpmxIGE72QB9xQiOasPf9XY9ILHrgqGk2cUy7gR2CHuYSC4FIH5QLbyvlt_DaBBXhR6u9WxUubQtbXcFRBadVZrUKzkOXw2dTqQLO226tPLxRpVoZqPJgPJx8B6-087XzpjMva6c_4Jv6MnBmw9oFb-tmewwOclU05mRXB2BxO5mP76PZ0910PJpFNYlliDThOsEsx2lCE6wZT0mW55JwQ3lMCZeUZpIijpSkDHOtGVPKUCEyQtI0k2QALn7v1t59tqYJy9I22hSFqoxrmyUSCRcCC8I7ev6Pblzruzc7JSVCnFMUd-psp9q0NNmy9rbsUlv-BUl-AMPjdFA</recordid><startdate>20161208</startdate><enddate>20161208</enddate><creator>Nasseh, Hamidreza</creator><creator>Abdi, Sepideh</creator><creator>Roshani, Ali</creator><creator>Kazemnezhad, Ehsan</creator><general>Urology and Nephrology Research Center</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161208</creationdate><title>Urinary Beta-2Microglobulin: An Indicator of Renal Tubular Damage after Extracorporeal Shock Wave Lithotripsy</title><author>Nasseh, Hamidreza ; Abdi, Sepideh ; Roshani, Ali ; Kazemnezhad, Ehsan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p309t-c37c426f2b4542c67b3dff937e570537955d95171a95627cc66aae588d33bbd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>beta 2-Microglobulin - urine</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Kidney Calculi - therapy</topic><topic>Kidney Tubules - injuries</topic><topic>Lithotripsy</topic><topic>Lithotripsy - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nasseh, Hamidreza</creatorcontrib><creatorcontrib>Abdi, Sepideh</creatorcontrib><creatorcontrib>Roshani, Ali</creatorcontrib><creatorcontrib>Kazemnezhad, Ehsan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Urology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nasseh, Hamidreza</au><au>Abdi, Sepideh</au><au>Roshani, Ali</au><au>Kazemnezhad, Ehsan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary Beta-2Microglobulin: An Indicator of Renal Tubular Damage after Extracorporeal Shock Wave Lithotripsy</atitle><jtitle>Urology journal</jtitle><addtitle>Urol J</addtitle><date>2016-12-08</date><risdate>2016</risdate><volume>13</volume><issue>6</issue><spage>2911</spage><epage>2915</epage><pages>2911-2915</pages><issn>1735-1308</issn><eissn>1735-546X</eissn><abstract>This study aims to determine extracorporeal shock wave lithotripsy (ESWL)-induced renal tubular damageand the affecting factors by measuring urinary beta2microglobulin (β2M) excretion.
This is a cross-sectional study conducted on 91 patients with renal stones who underwentESWL during 2012. Urinary beta2microglobulin was measured immediately before and after the procedure foreach patient and analyzed based on different variables to evaluate factors affecting ESWL-induced renal tubularinjury.
Mean ± SD urinary beta2-microglobulin values, before and after ESWL were 0.08 ± 0.07 and 0.22 ± 0.71mg/dL respectively, the average difference between which was equal to 0.14 ± 0.07 mg/dL. These figures exhibiteda 166.66% rise in the urinary β2M concentration after ESWL which was statistically significant (P < .001). Multivariateanalysis showed that hypertension (P = .05) and the history of ESWL (P = .02) were predictive factors ofhigher post-ESWL urinary beta2-microglobulin excretion.
Urinary excretion of beta2-microglobulin increased significantly immediately after ESWL. Thesechanges could indicate that ESWL is a contributing factor to renal tubular damage. It also seems that in patientswith hypertension and a previous history of ESWL the likelihood of this injury is higher than others.</abstract><cop>Iran</cop><pub>Urology and Nephrology Research Center</pub><pmid>27928813</pmid><doi>10.22037/UJ.V13I6.3624</doi><tpages>5</tpages></addata></record> |
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| subjects | beta 2-Microglobulin - urine Cross-Sectional Studies Female Humans Hypertension Kidney Calculi - therapy Kidney Tubules - injuries Lithotripsy Lithotripsy - adverse effects Male Middle Aged |
| title | Urinary Beta-2Microglobulin: An Indicator of Renal Tubular Damage after Extracorporeal Shock Wave Lithotripsy |
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