Evaluating the potential of the GFAP‐KLH immune‐tolerizing vaccine for type 1 diabetes in mice

Glial fibrillary acidic protein (GFAP), expressed in peri‐islet Schwann cells, is a novel target for the treatment of type 1 diabetes mellitus (T1DM). We designed a GFAP immune‐tolerizing vaccine that successfully suppresses hyperglycemia and enhances C peptide secretion. The GFAP vaccine significan...

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Veröffentlicht in:	FEBS letters 2017-01, Vol.591 (1), p.129-136
Hauptverfasser:	Pang, Zhengda, Higuchi, Masayoshi, Koriyama, Hiroshi, Yoshida, Shota, Kurinami, Hitomi, Shimamura, Munehisa, Takami, Yoichi, Rakugi, Hiromi, Morishita, Ryuichi, Nakagami, Hironori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals C-Peptide - biosynthesis Diabetes Mellitus, Type 1 - immunology Female glial fibrillary acidic protein Glial Fibrillary Acidic Protein - immunology Hemocyanins - immunology Immune Tolerance Immunity Immunoglobulin G - metabolism Interferon-gamma - biosynthesis Interleukin-4 - biosynthesis Mice, Inbred NOD Pancreas - pathology Phenotype Th1 Cells - immunology Th2 Cells - immunology type 1 diabetes Vaccination vaccine Vaccines - immunology
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