Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease

Chronic kidney disease (CKD) is associated with increased risk and worse prognosis of cardiovascular disease, including peripheral artery disease. An impaired angiogenic response to ischemia may contribute to poor outcomes of peripheral artery disease in patients with CKD. Hypoxia inducible factors...

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Veröffentlicht in:	Kidney international 2017-03, Vol.91 (3), p.616-627
Hauptverfasser:	Schellinger, Isabel N., Cordasic, Nada, Panesar, Julian, Buchholz, Björn, Jacobi, Johannes, Hartner, Andrea, Klanke, Bernd, Jakubiczka-Smorag, Joanna, Burzlaff, Nicolai, Heinze, Eva, Warnecke, Christina, Raaz, Uwe, Willam, Carsten, Tsao, Philip S., Eckardt, Kai-Uwe, Amann, Kerstin, Hilgers, Karl F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Capillaries - drug effects Capillaries - metabolism Capillaries - physiopathology Carbon Monoxide - pharmacology cardiovascular disease Cell Line chronic kidney disease Disease Models, Animal Gene Expression Regulation Glycine - analogs & derivatives Glycine - pharmacology Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - metabolism Hindlimb Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Ischemia - drug therapy Ischemia - genetics Ischemia - metabolism Ischemia - physiopathology Isoquinolines - pharmacology Male Muscle, Skeletal - blood supply Neovascularization, Physiologic - drug effects Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Protein Stability Rats, Sprague-Dawley Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - physiopathology Signal Transduction - drug effects Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism
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