Interaction of the c-Jun/JNK Pathway and Cyclin-dependent Kinases in Death of Embryonic Cortical Neurons Evoked by DNA Damage

DNA damage, an important initiator of neuronal death, has been implicated in numerous neurodegenerative conditions. We previously delineated several pathways that control embryonic cortical neuronal death evoked by the DNA-damaging agent, camptothecin. In this model, the tumor suppressor p53 and cyc...

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Veröffentlicht in:	The Journal of biological chemistry 2002-09, Vol.277 (38), p.35586-35596
Hauptverfasser:	Ghahremani, Mohammad H, Keramaris, Elizabeth, Shree, Tanaya, Xia, Zhengui, Davis, Roger J, Flavell, Richard, Slack, Ruth S, Park, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence bcl-2-Associated X Protein Camptothecin - pharmacology Cell Death Cerebral Cortex - cytology Cerebral Cortex - embryology Cyclin-Dependent Kinases - metabolism DNA Damage DNA Primers Gene Expression Regulation, Developmental - drug effects JNK Mitogen-Activated Protein Kinases Mice Mitogen-Activated Protein Kinases - metabolism Neurons - cytology Phosphorylation Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-jun - metabolism Tumor Suppressor Protein p53 - metabolism
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