AVOIDING UNTOWARD IMMUNE RESPONSES TO NOVEL GENE PRODUCTS
ABSTRACT For successful therapeutic transfection of a missing (or corrective) gene, by the use of liposomes or other delivery systems, it is essential that the patient be immunosuppressed to the corresponding immunogenic, transgenic protein prior to its transfection. We have developed a method for a...
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| Veröffentlicht in: | Journal of liposome research 2002-01, Vol.12 (1-2), p.199-204 |
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| container_end_page | 204 |
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| container_issue | 1-2 |
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| container_title | Journal of liposome research |
| container_volume | 12 |
| creator | Sehon, Alec H. Lang, Glen. M. |
| description | ABSTRACT
For successful therapeutic transfection of a missing (or corrective) gene, by the use of liposomes or other delivery systems, it is essential that the patient be immunosuppressed to the corresponding immunogenic, transgenic protein prior to its transfection. We have developed a method for antigen-specific, long-term suppression of de novo induction of both antibodies and cytotoxic T lymphocytes-in spite of repeated administration of the antigen in question over extended periods. The method consists of converting the antigen to its tolerogenic derivative by coupling it to an appropriate number of molecules of monomethoxypolyethylene glycol (mPEG).[1] |
| doi_str_mv | 10.1081/LPR-120004793 |
| format | Article |
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For successful therapeutic transfection of a missing (or corrective) gene, by the use of liposomes or other delivery systems, it is essential that the patient be immunosuppressed to the corresponding immunogenic, transgenic protein prior to its transfection. We have developed a method for antigen-specific, long-term suppression of de novo induction of both antibodies and cytotoxic T lymphocytes-in spite of repeated administration of the antigen in question over extended periods. The method consists of converting the antigen to its tolerogenic derivative by coupling it to an appropriate number of molecules of monomethoxypolyethylene glycol (mPEG).[1]</description><subject>Allergens - chemistry</subject><subject>Animals</subject><subject>Gene Transfer Techniques</subject><subject>Genetic Therapy - methods</subject><subject>Humans</subject><subject>Immunoglobulin E - metabolism</subject><subject>Immunotherapy - methods</subject><subject>Mice</subject><subject>Organ Transplantation - methods</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Rats</subject><subject>T-Lymphocytes, Cytotoxic - metabolism</subject><subject>Transfection</subject><issn>0898-2104</issn><issn>1532-2394</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9PwjAUxxujEUSPXs1O3qZ97bZ2RwITSWAj44fHpittgAym7Yjhv3cGovFAPL3k5fP95r0PQveAnwBzeB5Nch8IxjhgMb1AbQgp8QmNg0vUxjzmPgEctNCNc5sGIjwk16gFJMIBDoM2iruLbNgfpgNvns6yt27e94bj8TxNvDyZTrJ0mky9Weal2SIZeYOk2U_yrD_vzaa36MrI0um70-yg-Usy6736o2ww7HVHvgqA1T4ow6OiCFUUApbaRBGVrKAQQkF0aLThhNKAKay0YXHBlowvY8kZAKeaMUI76PHY-26rj712tdiundJlKXe62jvBmp8wjfC_IPCARYxCA_pHUNnKOauNeLfrrbQHAVh8SxWNVPEjteEfTsX7YquXv_TJYgPwI7Demcpu5Wdly6Wo5aGsrLFyp9ZO0HPd7E90pWVZr5S0Wmyqvd01Zs9c9QU1jY_n</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Sehon, Alec H.</creator><creator>Lang, Glen. M.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>AVOIDING UNTOWARD IMMUNE RESPONSES TO NOVEL GENE PRODUCTS</title><author>Sehon, Alec H. ; Lang, Glen. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-1cf86bb5c6510aef663a7b3151b2e5fef823347c0cef79b7d78d9a871183e7723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Allergens - chemistry</topic><topic>Animals</topic><topic>Gene Transfer Techniques</topic><topic>Genetic Therapy - methods</topic><topic>Humans</topic><topic>Immunoglobulin E - metabolism</topic><topic>Immunotherapy - methods</topic><topic>Mice</topic><topic>Organ Transplantation - methods</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>Rats</topic><topic>T-Lymphocytes, Cytotoxic - metabolism</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sehon, Alec H.</creatorcontrib><creatorcontrib>Lang, Glen. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of liposome research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sehon, Alec H.</au><au>Lang, Glen. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AVOIDING UNTOWARD IMMUNE RESPONSES TO NOVEL GENE PRODUCTS</atitle><jtitle>Journal of liposome research</jtitle><addtitle>J Liposome Res</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>12</volume><issue>1-2</issue><spage>199</spage><epage>204</epage><pages>199-204</pages><issn>0898-2104</issn><eissn>1532-2394</eissn><abstract>ABSTRACT
For successful therapeutic transfection of a missing (or corrective) gene, by the use of liposomes or other delivery systems, it is essential that the patient be immunosuppressed to the corresponding immunogenic, transgenic protein prior to its transfection. We have developed a method for antigen-specific, long-term suppression of de novo induction of both antibodies and cytotoxic T lymphocytes-in spite of repeated administration of the antigen in question over extended periods. The method consists of converting the antigen to its tolerogenic derivative by coupling it to an appropriate number of molecules of monomethoxypolyethylene glycol (mPEG).[1]</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>12604054</pmid><doi>10.1081/LPR-120004793</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0898-2104 |
| ispartof | Journal of liposome research, 2002-01, Vol.12 (1-2), p.199-204 |
| issn | 0898-2104 1532-2394 |
| language | eng |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Allergens - chemistry Animals Gene Transfer Techniques Genetic Therapy - methods Humans Immunoglobulin E - metabolism Immunotherapy - methods Mice Organ Transplantation - methods Polyethylene Glycols - pharmacology Rats T-Lymphocytes, Cytotoxic - metabolism Transfection |
| title | AVOIDING UNTOWARD IMMUNE RESPONSES TO NOVEL GENE PRODUCTS |
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