P2 receptor modulation and cytotoxic function in cultured CNS neurons

In this study we investigate the presence, modulation and biological function of P2 receptors and extracellular ATP in cultured cerebellar granule neurons. As we demonstrate by RT-PCR and western blotting, both P2X and P2Y receptor subtypes are expressed and furthermore regulated as a function of ne...

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Veröffentlicht in:	Neuropharmacology 2002-03, Vol.42 (4), p.489-501
Hauptverfasser:	Amadio, S., D’Ambrosi, N., Cavaliere, F., Murra, B., Sancesario, G., Bernardi, G., Burnstock, G., Volonté, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - physiology Adenosine Triphosphate - toxicity Adenosinic and purinergic receptors Animals Apoptosis Biological and medical sciences Cell receptors Cell structures and functions Cells, Cultured Central nervous system Central Nervous System - cytology Central Nervous System - drug effects Central Nervous System - physiology Central neurotransmission. Neuromudulation. Pathways and receptors Cerebellum - cytology Cerebellum - physiology Dose-Response Relationship, Drug Extracellular ATP Fundamental and applied biological sciences. Psychology Granule neurons Hippocampal organotypic cultures Hippocampus - cytology Hippocampus - drug effects Hippocampus - physiology Intracellular Fluid - drug effects Intracellular Fluid - physiology Membrane Potentials - drug effects Microelectrodes Molecular and cellular biology Necrosis Neurons - classification Neurons - cytology Neurons - drug effects Neurons - physiology P2 receptors Patch-Clamp Techniques Purinergic P2 Receptor Agonists Rats Rats, Wistar Receptors, Purinergic P2 - physiology Vertebrates: nervous system and sense organs
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