The RUNX1 Runt Domain at 1.25 Å Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding

The evolutionarily conserved Runt homology domain is characteristic of the RUNX family of heterodimeric eukaryotic transcription factors, including RUNX1, RUNX2 and RUNX3. The genes for RUNX1, also termed acute myeloid leukemia protein 1, AML1, and its dimerization partner core-binding factor β, CBF...

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Veröffentlicht in:	Journal of molecular biology 2002, Vol.322 (2), p.259-272
Hauptverfasser:	Bäckström, Stefan, Wolf-Watz, Magnus, Grundström, Christine, Härd, Torleif, Grundström, Thomas, Sauer, Uwe H.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myeloid leukemia chloride binding high-resolution crystal structure RUNX1 Runt DNA-binding domain transcription regulation
Online-Zugang:	Volltext
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