Toward Understanding the Mutagenicity of an Environmental Carcinogen: Structural Insights into Nucleotide Incorporation Preferences

Bulky carcinogen–DNA adducts, including (+)- trans- anti-[BP]- N 2-dG derived from the reaction of (+)- anti-benzo[ a]pyrene diol epoxide with guanine, often block the progression of DNA polymerases. However, when rare bypass of the lesions does occur, they may be misreplicated. Experimental results...

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