Genetic Basis of Attenuation of Dengue Virus Type 4 Small Plaque Mutants with Restricted Replication in Suckling Mice and in SCID Mice Transplanted with Human Liver Cells

Mutations that restrict replication of dengue virus have been sought for the generation of recombinant live-attenuated dengue virus vaccines. Dengue virus type 4 (DEN4) was previously grown in Vero cells in the presence of 5-fluorouracil, and the characterization of 1248 mutagenized, Vero cell passa...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2002-08, Vol.300 (1), p.125-139
Hauptverfasser:	Blaney, Joseph E., Johnson, Daniel H., Manipon, Gracielle G., Firestone, Cai-Yen, Hanson, Christopher T., Murphy, Brian R., Whitehead, Stephen S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Suckling attenuation Cell Transplantation Cercopithecus aethiops Dengue virus Dengue Virus - genetics Dengue Virus - physiology Humans Liver Transplantation Mice Mice, SCID mutagenesis Mutation Phenotype Recombination, Genetic small-plaque temperature-sensitive Transplantation, Heterologous vaccine Vero Cells Viral Plaque Assay Virus Replication - physiology
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