Nutritional interventions that slow the age-associated decline in renal function in a canine geriatric model for elderly humans
Objective To determine the effects of feeding traditional and renal protective foods (RPF) supplemented with functional food bioactives on glomerular filtration rate (GFR), lean body percent (LB%), and selected circulating biomarker and metabolite concentrations in a geriatric dog model. Design Rand...
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| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2016-12, Vol.20 (10), p.1010-1023 |
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| creator | Hall, Jean A. Yerramilli, M. Obare, E. Panickar, K. S. Bobe, G. Jewell, D. E. |
| description | Objective
To determine the effects of feeding traditional and renal protective foods (RPF) supplemented with functional food bioactives on glomerular filtration rate (GFR), lean body percent (LB%), and selected circulating biomarker and metabolite concentrations in a geriatric dog model.
Design
Randomized block design and cross-sectional study. Setting: Hill’s Pet Nutrition, Inc. dog colony.
Participants
Eighty-one geriatric dogs (mean age, 10.4; range, 7.9-14.2 years) and 30 mature-adult dogs (mean age, 5.0; range, 3.3-6.9 years).
Intervention
Geriatric dogs were fed one of three foods (n = 27 per group) for 6 months: a traditional RPF (control) that was energy dense and mildly protein-restricted, or control food supplemented with increasing amounts of functional food bioactives: fish oil, lipoic acid, fruits and vegetables, and higher quality protein sources [functional foods one (FF1) and two (FF2)]. Geriatric dogs were compared before and after the feeding trial with mature adult dogs.
Measurements
Renal function was assessed by GFR, LB% was determined by dual energy x-ray absorptiometry, and circulating biomarkers and metabolites were measured in blood.
Results
Before the feeding trial, GFR (+28.2%), LB% (+18.6%), and serum total protein (+10.0%) were higher in mature versus healthy geriatric dogs (all P |
| doi_str_mv | 10.1007/s12603-015-0636-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1846722735</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1846722735</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-3301bdd1e667a1ed4b497b046c8b7038b121e2004fa5be5e0512202513c490a13</originalsourceid><addsrcrecordid>eNp1kctu1jAQhS0EoqXwAGyQJTZsDDO-JktUlYtUwQbWluPM36ZK7GInoK54dRz9BSEkVh7PfOdY48PYc4TXCODeVJQWlAA0AqyyQj1gp-gsCO267mGrpeuFc-BO2JNabwC06Tv7mJ20vjSo8ZT9_LStZVqnnMLMp7RS-U5pv1a-XoeV1zn_aBXxcEUi1JrjFFYa-UhxnhI1CS-0aw9birtu7wQeQ9qnV1QaXqbIlzxSg3LhNI9U5jt-vS0h1afs0SHMlZ7dn2fs67uLL-cfxOXn9x_P316KqNGsQinAYRyRrHUBadSD7t0A2sZucKC6ASWSbAseghnIEBiUEtqOKuoeAqoz9uroe1vyt43q6pepRprnkChv1WOnrZPSKdPQl_-gN3krbcedMhax17ZvFB6pWHKthQ7-tkxLKHcewe_p-GM6vqXj93S8apoX987bsND4R_E7jgbII1DbKLXf--vp_7r-ApgTmrY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1856119469</pqid></control><display><type>article</type><title>Nutritional interventions that slow the age-associated decline in renal function in a canine geriatric model for elderly humans</title><source>MEDLINE</source><source>Springer Journals</source><source>Alma/SFX Local Collection</source><creator>Hall, Jean A. ; Yerramilli, M. ; Obare, E. ; Panickar, K. S. ; Bobe, G. ; Jewell, D. E.</creator><creatorcontrib>Hall, Jean A. ; Yerramilli, M. ; Obare, E. ; Panickar, K. S. ; Bobe, G. ; Jewell, D. E.</creatorcontrib><description>Objective
To determine the effects of feeding traditional and renal protective foods (RPF) supplemented with functional food bioactives on glomerular filtration rate (GFR), lean body percent (LB%), and selected circulating biomarker and metabolite concentrations in a geriatric dog model.
Design
Randomized block design and cross-sectional study. Setting: Hill’s Pet Nutrition, Inc. dog colony.
Participants
Eighty-one geriatric dogs (mean age, 10.4; range, 7.9-14.2 years) and 30 mature-adult dogs (mean age, 5.0; range, 3.3-6.9 years).
Intervention
Geriatric dogs were fed one of three foods (n = 27 per group) for 6 months: a traditional RPF (control) that was energy dense and mildly protein-restricted, or control food supplemented with increasing amounts of functional food bioactives: fish oil, lipoic acid, fruits and vegetables, and higher quality protein sources [functional foods one (FF1) and two (FF2)]. Geriatric dogs were compared before and after the feeding trial with mature adult dogs.
Measurements
Renal function was assessed by GFR, LB% was determined by dual energy x-ray absorptiometry, and circulating biomarkers and metabolites were measured in blood.
Results
Before the feeding trial, GFR (+28.2%), LB% (+18.6%), and serum total protein (+10.0%) were higher in mature versus healthy geriatric dogs (all P<0.001). Geriatric dogs consuming all three foods increased (P<0.001) GFR over time; group averages ranged from 13.0–16.9%. Dogs fed the highest supplemented level of bioactives (FF2) had lower (P<0.001) symmetric dimethylarginine (SDMA) concentrations (-14.3%). Feeding functional foods did not alter body weight, but increased (P<0.001) serum protein concentration (+6.7%).
Conclusion
Supplementation with functional food bioactives can temporarily reverse the age-associated decline in renal function and serum total protein.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-015-0636-3</identifier><identifier>PMID: 27925141</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject><![CDATA[Absorptiometry, Photon ; Age ; Aged ; Aging ; Aging - blood ; Animals ; Arginine - analogs & derivatives ; Arginine - blood ; Biomarkers ; Biomarkers - blood ; Body Weight ; Carnitine - blood ; Cross-Sectional Studies ; Diet - veterinary ; Dietary Proteins - administration & dosage ; Dietary Proteins - blood ; Dietary Supplements ; Disease Models, Animal ; Dogs ; Fatty acids ; Female ; Fish oils ; Fish Oils - administration & dosage ; Fish Oils - blood ; Food ; Fruit ; Fruits ; Functional foods & nutraceuticals ; Geriatric Assessment ; Geriatrics ; Geriatrics/Gerontology ; Glomerular Filtration Rate ; Humans ; Hypotheses ; Kidney - physiology ; Kidney - physiopathology ; Kidney diseases ; Male ; Medicine ; Medicine & Public Health ; Metabolites ; Neurosciences ; Nutrition ; Pets ; Primary Care Medicine ; Proteins ; Quality of Life Research ; Sarcopenia ; Thioctic Acid - administration & dosage ; Thioctic Acid - blood ; Vegetables ; Veterinary colleges ; Veterinary medicine]]></subject><ispartof>The Journal of nutrition, health & aging, 2016-12, Vol.20 (10), p.1010-1023</ispartof><rights>Serdi and Springer-Verlag France 2016</rights><rights>The journal of nutrition, health & aging is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-3301bdd1e667a1ed4b497b046c8b7038b121e2004fa5be5e0512202513c490a13</citedby><cites>FETCH-LOGICAL-c415t-3301bdd1e667a1ed4b497b046c8b7038b121e2004fa5be5e0512202513c490a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-015-0636-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-015-0636-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27925141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hall, Jean A.</creatorcontrib><creatorcontrib>Yerramilli, M.</creatorcontrib><creatorcontrib>Obare, E.</creatorcontrib><creatorcontrib>Panickar, K. S.</creatorcontrib><creatorcontrib>Bobe, G.</creatorcontrib><creatorcontrib>Jewell, D. E.</creatorcontrib><title>Nutritional interventions that slow the age-associated decline in renal function in a canine geriatric model for elderly humans</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Objective
To determine the effects of feeding traditional and renal protective foods (RPF) supplemented with functional food bioactives on glomerular filtration rate (GFR), lean body percent (LB%), and selected circulating biomarker and metabolite concentrations in a geriatric dog model.
Design
Randomized block design and cross-sectional study. Setting: Hill’s Pet Nutrition, Inc. dog colony.
Participants
Eighty-one geriatric dogs (mean age, 10.4; range, 7.9-14.2 years) and 30 mature-adult dogs (mean age, 5.0; range, 3.3-6.9 years).
Intervention
Geriatric dogs were fed one of three foods (n = 27 per group) for 6 months: a traditional RPF (control) that was energy dense and mildly protein-restricted, or control food supplemented with increasing amounts of functional food bioactives: fish oil, lipoic acid, fruits and vegetables, and higher quality protein sources [functional foods one (FF1) and two (FF2)]. Geriatric dogs were compared before and after the feeding trial with mature adult dogs.
Measurements
Renal function was assessed by GFR, LB% was determined by dual energy x-ray absorptiometry, and circulating biomarkers and metabolites were measured in blood.
Results
Before the feeding trial, GFR (+28.2%), LB% (+18.6%), and serum total protein (+10.0%) were higher in mature versus healthy geriatric dogs (all P<0.001). Geriatric dogs consuming all three foods increased (P<0.001) GFR over time; group averages ranged from 13.0–16.9%. Dogs fed the highest supplemented level of bioactives (FF2) had lower (P<0.001) symmetric dimethylarginine (SDMA) concentrations (-14.3%). Feeding functional foods did not alter body weight, but increased (P<0.001) serum protein concentration (+6.7%).
Conclusion
Supplementation with functional food bioactives can temporarily reverse the age-associated decline in renal function and serum total protein.</description><subject>Absorptiometry, Photon</subject><subject>Age</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - blood</subject><subject>Animals</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - blood</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Body Weight</subject><subject>Carnitine - blood</subject><subject>Cross-Sectional Studies</subject><subject>Diet - veterinary</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Dietary Proteins - blood</subject><subject>Dietary Supplements</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Fish oils</subject><subject>Fish Oils - administration & dosage</subject><subject>Fish Oils - blood</subject><subject>Food</subject><subject>Fruit</subject><subject>Fruits</subject><subject>Functional foods & nutraceuticals</subject><subject>Geriatric Assessment</subject><subject>Geriatrics</subject><subject>Geriatrics/Gerontology</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Kidney - physiology</subject><subject>Kidney - physiopathology</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolites</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Pets</subject><subject>Primary Care Medicine</subject><subject>Proteins</subject><subject>Quality of Life Research</subject><subject>Sarcopenia</subject><subject>Thioctic Acid - administration & dosage</subject><subject>Thioctic Acid - blood</subject><subject>Vegetables</subject><subject>Veterinary colleges</subject><subject>Veterinary medicine</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kctu1jAQhS0EoqXwAGyQJTZsDDO-JktUlYtUwQbWluPM36ZK7GInoK54dRz9BSEkVh7PfOdY48PYc4TXCODeVJQWlAA0AqyyQj1gp-gsCO267mGrpeuFc-BO2JNabwC06Tv7mJ20vjSo8ZT9_LStZVqnnMLMp7RS-U5pv1a-XoeV1zn_aBXxcEUi1JrjFFYa-UhxnhI1CS-0aw9birtu7wQeQ9qnV1QaXqbIlzxSg3LhNI9U5jt-vS0h1afs0SHMlZ7dn2fs67uLL-cfxOXn9x_P316KqNGsQinAYRyRrHUBadSD7t0A2sZucKC6ASWSbAseghnIEBiUEtqOKuoeAqoz9uroe1vyt43q6pepRprnkChv1WOnrZPSKdPQl_-gN3krbcedMhax17ZvFB6pWHKthQ7-tkxLKHcewe_p-GM6vqXj93S8apoX987bsND4R_E7jgbII1DbKLXf--vp_7r-ApgTmrY</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Hall, Jean A.</creator><creator>Yerramilli, M.</creator><creator>Obare, E.</creator><creator>Panickar, K. S.</creator><creator>Bobe, G.</creator><creator>Jewell, D. E.</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Nutritional interventions that slow the age-associated decline in renal function in a canine geriatric model for elderly humans</title><author>Hall, Jean A. ; Yerramilli, M. ; Obare, E. ; Panickar, K. S. ; Bobe, G. ; Jewell, D. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-3301bdd1e667a1ed4b497b046c8b7038b121e2004fa5be5e0512202513c490a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Absorptiometry, Photon</topic><topic>Age</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging - blood</topic><topic>Animals</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - blood</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Body Weight</topic><topic>Carnitine - blood</topic><topic>Cross-Sectional Studies</topic><topic>Diet - veterinary</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Dietary Proteins - blood</topic><topic>Dietary Supplements</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Fish oils</topic><topic>Fish Oils - administration & dosage</topic><topic>Fish Oils - blood</topic><topic>Food</topic><topic>Fruit</topic><topic>Fruits</topic><topic>Functional foods & nutraceuticals</topic><topic>Geriatric Assessment</topic><topic>Geriatrics</topic><topic>Geriatrics/Gerontology</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Kidney - physiology</topic><topic>Kidney - physiopathology</topic><topic>Kidney diseases</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolites</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Pets</topic><topic>Primary Care Medicine</topic><topic>Proteins</topic><topic>Quality of Life Research</topic><topic>Sarcopenia</topic><topic>Thioctic Acid - administration & dosage</topic><topic>Thioctic Acid - blood</topic><topic>Vegetables</topic><topic>Veterinary colleges</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hall, Jean A.</creatorcontrib><creatorcontrib>Yerramilli, M.</creatorcontrib><creatorcontrib>Obare, E.</creatorcontrib><creatorcontrib>Panickar, K. S.</creatorcontrib><creatorcontrib>Bobe, G.</creatorcontrib><creatorcontrib>Jewell, D. E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Databases</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hall, Jean A.</au><au>Yerramilli, M.</au><au>Obare, E.</au><au>Panickar, K. S.</au><au>Bobe, G.</au><au>Jewell, D. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nutritional interventions that slow the age-associated decline in renal function in a canine geriatric model for elderly humans</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>20</volume><issue>10</issue><spage>1010</spage><epage>1023</epage><pages>1010-1023</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Objective
To determine the effects of feeding traditional and renal protective foods (RPF) supplemented with functional food bioactives on glomerular filtration rate (GFR), lean body percent (LB%), and selected circulating biomarker and metabolite concentrations in a geriatric dog model.
Design
Randomized block design and cross-sectional study. Setting: Hill’s Pet Nutrition, Inc. dog colony.
Participants
Eighty-one geriatric dogs (mean age, 10.4; range, 7.9-14.2 years) and 30 mature-adult dogs (mean age, 5.0; range, 3.3-6.9 years).
Intervention
Geriatric dogs were fed one of three foods (n = 27 per group) for 6 months: a traditional RPF (control) that was energy dense and mildly protein-restricted, or control food supplemented with increasing amounts of functional food bioactives: fish oil, lipoic acid, fruits and vegetables, and higher quality protein sources [functional foods one (FF1) and two (FF2)]. Geriatric dogs were compared before and after the feeding trial with mature adult dogs.
Measurements
Renal function was assessed by GFR, LB% was determined by dual energy x-ray absorptiometry, and circulating biomarkers and metabolites were measured in blood.
Results
Before the feeding trial, GFR (+28.2%), LB% (+18.6%), and serum total protein (+10.0%) were higher in mature versus healthy geriatric dogs (all P<0.001). Geriatric dogs consuming all three foods increased (P<0.001) GFR over time; group averages ranged from 13.0–16.9%. Dogs fed the highest supplemented level of bioactives (FF2) had lower (P<0.001) symmetric dimethylarginine (SDMA) concentrations (-14.3%). Feeding functional foods did not alter body weight, but increased (P<0.001) serum protein concentration (+6.7%).
Conclusion
Supplementation with functional food bioactives can temporarily reverse the age-associated decline in renal function and serum total protein.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>27925141</pmid><doi>10.1007/s12603-015-0636-3</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1279-7707 |
| ispartof | The Journal of nutrition, health & aging, 2016-12, Vol.20 (10), p.1010-1023 |
| issn | 1279-7707 1760-4788 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1846722735 |
| source | MEDLINE; Springer Journals; Alma/SFX Local Collection |
| subjects | Absorptiometry, Photon Age Aged Aging Aging - blood Animals Arginine - analogs & derivatives Arginine - blood Biomarkers Biomarkers - blood Body Weight Carnitine - blood Cross-Sectional Studies Diet - veterinary Dietary Proteins - administration & dosage Dietary Proteins - blood Dietary Supplements Disease Models, Animal Dogs Fatty acids Female Fish oils Fish Oils - administration & dosage Fish Oils - blood Food Fruit Fruits Functional foods & nutraceuticals Geriatric Assessment Geriatrics Geriatrics/Gerontology Glomerular Filtration Rate Humans Hypotheses Kidney - physiology Kidney - physiopathology Kidney diseases Male Medicine Medicine & Public Health Metabolites Neurosciences Nutrition Pets Primary Care Medicine Proteins Quality of Life Research Sarcopenia Thioctic Acid - administration & dosage Thioctic Acid - blood Vegetables Veterinary colleges Veterinary medicine |
| title | Nutritional interventions that slow the age-associated decline in renal function in a canine geriatric model for elderly humans |
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