The effect of ezetimibe monotheraphy on mean platelet volume in patients with hyperlipidaemia: a retrospective study of 45 patients

To investigate the effect of ezetimibe on platelet functions as a drug which increases mevalonate levels. This retrospective study was conducted in Istanbul, Turkey, and comprised record of normolipidaemic and hyperlipidaemic patients taken from the outpatient clinic from October 2004 to February 20...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the Pakistan Medical Association 2016-12, Vol.66 (12), p.1559-1561
Hauptverfasser:	Sertbas, Yasar, Sertbas, Meltem, Ersoy, Ugur, Bilir, Bulent, Gunaydin, Seracettin, Ozdemir, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticholesteremic Agents - pharmacology Ezetimibe - pharmacology Humans Hyperlipidemias - drug therapy Mean Platelet Volume Retrospective Studies Turkey
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	1561
container_issue	12
container_start_page	1559
container_title	Journal of the Pakistan Medical Association
container_volume	66
creator	Sertbas, Yasar Sertbas, Meltem Ersoy, Ugur Bilir, Bulent Gunaydin, Seracettin Ozdemir, Ali
description	To investigate the effect of ezetimibe on platelet functions as a drug which increases mevalonate levels. This retrospective study was conducted in Istanbul, Turkey, and comprised record of normolipidaemic and hyperlipidaemic patients taken from the outpatient clinic from October 2004 to February 2015,. The results were taken from the baseline and third-month data of ezetimibe treatment. SPSS 22 was used for statistical analysis. Of the total, there were 50(53%) normolipidaemic patients and 45(47%) hyperlipidaemic ones. Pre- and post-treatment values of mean platelet volume were significantly higher in the hyperlipidaemic group than controls (p0.05). The use of ezetimibe alone should not be the first choice in hyperlipidaemia treatment.
format	Article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1846722140</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1846722140</sourcerecordid><originalsourceid>FETCH-LOGICAL-p211t-6f64189553312e5d0df2db71a057a2bcdb740f303139d9a854aac6edc5a8372d3</originalsourceid><addsrcrecordid>eNo9UEtLxDAY7EFx19W_IDl6KeTR9OFNFh8LC17Wc_nafKWRpIlNulKv_nErrp5mGOYBc5asKRU0raqSr5LLEN4o5bmk9CJZ8aLiWZXLdfJ16JFg12EbiesIfmLUVjdIrBtc7HEE38_EDcQiDMQbiGgwkqMzk0WiFwmixiEG8qFjT_rZ42i01wrQargjQEaMowt-GdBHJCFOav5ZyuR_9Co578AEvD7hJnl9fDhsn9P9y9Nue79PPWcspnmXZ6yspBSCcZSKqo6rpmBAZQG8aRee0U5QwUSlKihlBtDmqFoJpSi4Epvk9rfXj-59whBrq0OLxsCAbgo1K7O84JxldLHenKxTY1HVftQWxrn-O058A3LTa0Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1846722140</pqid></control><display><type>article</type><title>The effect of ezetimibe monotheraphy on mean platelet volume in patients with hyperlipidaemia: a retrospective study of 45 patients</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Sertbas, Yasar ; Sertbas, Meltem ; Ersoy, Ugur ; Bilir, Bulent ; Gunaydin, Seracettin ; Ozdemir, Ali</creator><creatorcontrib>Sertbas, Yasar ; Sertbas, Meltem ; Ersoy, Ugur ; Bilir, Bulent ; Gunaydin, Seracettin ; Ozdemir, Ali</creatorcontrib><description>To investigate the effect of ezetimibe on platelet functions as a drug which increases mevalonate levels. This retrospective study was conducted in Istanbul, Turkey, and comprised record of normolipidaemic and hyperlipidaemic patients taken from the outpatient clinic from October 2004 to February 2015,. The results were taken from the baseline and third-month data of ezetimibe treatment. SPSS 22 was used for statistical analysis. Of the total, there were 50(53%) normolipidaemic patients and 45(47%) hyperlipidaemic ones. Pre- and post-treatment values of mean platelet volume were significantly higher in the hyperlipidaemic group than controls (p<0.001). In the hyperlipidaemic group there was no significant difference between pre- and post-treatment values of mean platelet volume (8.96±0.93 vs. 8.92±0.84; p>0.05). The use of ezetimibe alone should not be the first choice in hyperlipidaemia treatment.</description><identifier>ISSN: 0030-9982</identifier><identifier>PMID: 27924965</identifier><language>eng</language><publisher>Pakistan</publisher><subject>Anticholesteremic Agents - pharmacology ; Ezetimibe - pharmacology ; Humans ; Hyperlipidemias - drug therapy ; Mean Platelet Volume ; Retrospective Studies ; Turkey</subject><ispartof>Journal of the Pakistan Medical Association, 2016-12, Vol.66 (12), p.1559-1561</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27924965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sertbas, Yasar</creatorcontrib><creatorcontrib>Sertbas, Meltem</creatorcontrib><creatorcontrib>Ersoy, Ugur</creatorcontrib><creatorcontrib>Bilir, Bulent</creatorcontrib><creatorcontrib>Gunaydin, Seracettin</creatorcontrib><creatorcontrib>Ozdemir, Ali</creatorcontrib><title>The effect of ezetimibe monotheraphy on mean platelet volume in patients with hyperlipidaemia: a retrospective study of 45 patients</title><title>Journal of the Pakistan Medical Association</title><addtitle>J Pak Med Assoc</addtitle><description>To investigate the effect of ezetimibe on platelet functions as a drug which increases mevalonate levels. This retrospective study was conducted in Istanbul, Turkey, and comprised record of normolipidaemic and hyperlipidaemic patients taken from the outpatient clinic from October 2004 to February 2015,. The results were taken from the baseline and third-month data of ezetimibe treatment. SPSS 22 was used for statistical analysis. Of the total, there were 50(53%) normolipidaemic patients and 45(47%) hyperlipidaemic ones. Pre- and post-treatment values of mean platelet volume were significantly higher in the hyperlipidaemic group than controls (p<0.001). In the hyperlipidaemic group there was no significant difference between pre- and post-treatment values of mean platelet volume (8.96±0.93 vs. 8.92±0.84; p>0.05). The use of ezetimibe alone should not be the first choice in hyperlipidaemia treatment.</description><subject>Anticholesteremic Agents - pharmacology</subject><subject>Ezetimibe - pharmacology</subject><subject>Humans</subject><subject>Hyperlipidemias - drug therapy</subject><subject>Mean Platelet Volume</subject><subject>Retrospective Studies</subject><subject>Turkey</subject><issn>0030-9982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UEtLxDAY7EFx19W_IDl6KeTR9OFNFh8LC17Wc_nafKWRpIlNulKv_nErrp5mGOYBc5asKRU0raqSr5LLEN4o5bmk9CJZ8aLiWZXLdfJ16JFg12EbiesIfmLUVjdIrBtc7HEE38_EDcQiDMQbiGgwkqMzk0WiFwmixiEG8qFjT_rZ42i01wrQargjQEaMowt-GdBHJCFOav5ZyuR_9Co578AEvD7hJnl9fDhsn9P9y9Nue79PPWcspnmXZ6yspBSCcZSKqo6rpmBAZQG8aRee0U5QwUSlKihlBtDmqFoJpSi4Epvk9rfXj-59whBrq0OLxsCAbgo1K7O84JxldLHenKxTY1HVftQWxrn-O058A3LTa0Q</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Sertbas, Yasar</creator><creator>Sertbas, Meltem</creator><creator>Ersoy, Ugur</creator><creator>Bilir, Bulent</creator><creator>Gunaydin, Seracettin</creator><creator>Ozdemir, Ali</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201612</creationdate><title>The effect of ezetimibe monotheraphy on mean platelet volume in patients with hyperlipidaemia: a retrospective study of 45 patients</title><author>Sertbas, Yasar ; Sertbas, Meltem ; Ersoy, Ugur ; Bilir, Bulent ; Gunaydin, Seracettin ; Ozdemir, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-6f64189553312e5d0df2db71a057a2bcdb740f303139d9a854aac6edc5a8372d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anticholesteremic Agents - pharmacology</topic><topic>Ezetimibe - pharmacology</topic><topic>Humans</topic><topic>Hyperlipidemias - drug therapy</topic><topic>Mean Platelet Volume</topic><topic>Retrospective Studies</topic><topic>Turkey</topic><toplevel>online_resources</toplevel><creatorcontrib>Sertbas, Yasar</creatorcontrib><creatorcontrib>Sertbas, Meltem</creatorcontrib><creatorcontrib>Ersoy, Ugur</creatorcontrib><creatorcontrib>Bilir, Bulent</creatorcontrib><creatorcontrib>Gunaydin, Seracettin</creatorcontrib><creatorcontrib>Ozdemir, Ali</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Pakistan Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sertbas, Yasar</au><au>Sertbas, Meltem</au><au>Ersoy, Ugur</au><au>Bilir, Bulent</au><au>Gunaydin, Seracettin</au><au>Ozdemir, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of ezetimibe monotheraphy on mean platelet volume in patients with hyperlipidaemia: a retrospective study of 45 patients</atitle><jtitle>Journal of the Pakistan Medical Association</jtitle><addtitle>J Pak Med Assoc</addtitle><date>2016-12</date><risdate>2016</risdate><volume>66</volume><issue>12</issue><spage>1559</spage><epage>1561</epage><pages>1559-1561</pages><issn>0030-9982</issn><abstract>To investigate the effect of ezetimibe on platelet functions as a drug which increases mevalonate levels. This retrospective study was conducted in Istanbul, Turkey, and comprised record of normolipidaemic and hyperlipidaemic patients taken from the outpatient clinic from October 2004 to February 2015,. The results were taken from the baseline and third-month data of ezetimibe treatment. SPSS 22 was used for statistical analysis. Of the total, there were 50(53%) normolipidaemic patients and 45(47%) hyperlipidaemic ones. Pre- and post-treatment values of mean platelet volume were significantly higher in the hyperlipidaemic group than controls (p<0.001). In the hyperlipidaemic group there was no significant difference between pre- and post-treatment values of mean platelet volume (8.96±0.93 vs. 8.92±0.84; p>0.05). The use of ezetimibe alone should not be the first choice in hyperlipidaemia treatment.</abstract><cop>Pakistan</cop><pmid>27924965</pmid><tpages>3</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0030-9982
ispartof	Journal of the Pakistan Medical Association, 2016-12, Vol.66 (12), p.1559-1561
issn	0030-9982
language	eng
recordid	cdi_proquest_miscellaneous_1846722140
source	MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals
subjects	Anticholesteremic Agents - pharmacology Ezetimibe - pharmacology Humans Hyperlipidemias - drug therapy Mean Platelet Volume Retrospective Studies Turkey
title	The effect of ezetimibe monotheraphy on mean platelet volume in patients with hyperlipidaemia: a retrospective study of 45 patients
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T23%3A07%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20ezetimibe%20monotheraphy%20on%20mean%20platelet%20volume%20in%20patients%20with%20hyperlipidaemia:%20a%20retrospective%20study%20of%2045%20patients&rft.jtitle=Journal%20of%20the%20Pakistan%20Medical%20Association&rft.au=Sertbas,%20Yasar&rft.date=2016-12&rft.volume=66&rft.issue=12&rft.spage=1559&rft.epage=1561&rft.pages=1559-1561&rft.issn=0030-9982&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1846722140%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1846722140&rft_id=info:pmid/27924965&rfr_iscdi=true