In vivo anti-inflammatory activity and docking study of newly synthesized benzimidazole derivatives bearing oxadiazole and morpholine rings

A series of 18 newer benzimidazole derivatives (5a-r) were synthesized linked with morpholine and oxadiazole rings with the aim to improve the anti-inflammatory and reduce the ulcerogenic effects. The compound 5g showed maximum anti-inflammatory activity of 74.17±1.28 (% Inhibition±SEM) and ulceroge...

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Veröffentlicht in:	Bioorganic chemistry 2017-02, Vol.70, p.107-117
Hauptverfasser:	Rathore, Ankita, Sudhakar, Raja, Ahsan, Mohamed Jawed, Ali, Abuzer, Subbarao, Naidu, Jadav, Surender Singh, Umar, Sadiq, Yar, M. Shahar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Benzimidazole Benzimidazoles - adverse effects Benzimidazoles - chemistry Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Cyclooxygenase 2 Inhibitors - adverse effects Cyclooxygenase 2 Inhibitors - chemistry Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase 2 Inhibitors - therapeutic use Edema - drug therapy Lipid peroxidation Male Models, Molecular Molecular docking Molecular Docking Simulation Oxadiazole Oxadiazoles - adverse effects Oxadiazoles - chemistry Oxadiazoles - pharmacology Oxadiazoles - therapeutic use Rats, Wistar Ulcer - chemically induced Ulcerogenic activity
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