Gatifloxacin-Associated Corrected QT Interval Prolongation, Torsades de Pointes, and Ventricular Fibrillation in Patients with Known Risk Factors

Drugs not commonly considered to be cardioactive agents have been reported to cause prolongation of the corrected QT interval with resultant torsades de pointes or ventricular fibrillation. We report 4 cases of gatifloxacin-associated cardiac toxicity in patients with known risk factors for this adv...

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Veröffentlicht in:	Clinical infectious diseases 2002-03, Vol.34 (6), p.861-863
Hauptverfasser:	Bertino, Joseph S., Owens, Robert C., Carnes, Timothy D., Iannini, Paul B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anti-Infective Agents - adverse effects Biological and medical sciences Brief Reports Cardiac dysrhythmias Cardiology. Vascular system Cardiovascular agents Congestive heart failure Dosage Drug toxicity and drugs side effects treatment Female Fluoroquinolones Heart Heart - drug effects Humans Infectious diseases Long QT Syndrome Medical sciences Medications Middle Aged Musical intervals Pharmacology. Drug treatments Predisposing factors Risk Factors Torsades de Pointes Torsades de Pointes - chemically induced Toxicity: cardiovascular system Ventricular fibrillation Ventricular Fibrillation - chemically induced
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Zusammenfassung:	Drugs not commonly considered to be cardioactive agents have been reported to cause prolongation of the corrected QT interval with resultant torsades de pointes or ventricular fibrillation. We report 4 cases of gatifloxacin-associated cardiac toxicity in patients with known risk factors for this adverse event.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/339075