miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD

ObjectiveMicroRNA (miR)-301a is known to be involved in the tumourigenesis and pathogenesis of several autoimmune diseases, but it remains unclear whether miR-301a is associated with the pathogenesis of IBD.MethodsmiR-301a expression was assessed in peripheral blood mononuclear cells (PBMC) and infl...

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Veröffentlicht in:	Gut 2016-12, Vol.65 (12), p.1938-1950
Hauptverfasser:	He, Chong, Shi, Yan, Wu, Ruijin, Sun, Mingming, Fang, Leilei, Wu, Wei, Liu, Changqin, Tang, Maochun, Li, Zhong, Wang, Ping, Cong, Yingzi, Liu, Zhanju
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - blood Case-Control Studies CD4-Positive T-Lymphocytes - immunology Disease Models, Animal Humans In Vitro Techniques Inflammation - immunology Inflammatory Bowel Diseases - blood Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology Interleukin-17 - blood Interleukin-17 - immunology Intestinal Mucosa - immunology Intestinal Mucosa - pathology Mice MicroRNAs - blood MicroRNAs - immunology Prognosis Severity of Illness Index Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology
Online-Zugang:	Volltext
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