Vancomycin-resistant enterococcal bloodstream infections in hematopoietic stem cell transplant recipients and patients with hematologic malignancies: impact of daptomycin MICs of 3 to 4 mg/L

Abstract Purpose Case reports of treatment failure with standard-dose daptomycin (6 mg/kg) have recently surfaced in vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI) episodes with daptomycin MICs of 3 to 4 mg/L. The clinical implications of daptomycin MICs of 3 to 4 mg/L in VRE BS...

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Veröffentlicht in:	Clinical therapeutics 2016-11, Vol.38 (11), p.2468-2476
Hauptverfasser:	Chong, Pearlie P., MD, van Duin, David, MD, PhD, Bangdiwala, Ananta, MD, MPH, Ivanova, Anastasia, PhD, Miller, William C., MD, PhD, MPH, Weber, David J., MD, MPH, Gilligan, Peter H., PhD, Shea, Thomas C., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Bacterial Agents - therapeutic use Antibiotics bacteremia Bacteremia - drug therapy Bone marrow Catheters daptomycin Daptomycin - therapeutic use Endoscopy Enterococcus Enterococcus faecium Enterococcus faecium - drug effects Female Hematologic Neoplasms - pathology Hematopoietic Stem Cell Transplantation Humans Infections Intensive care Internal Medicine Leukemia Male Medical Education Microbial Sensitivity Tests Middle Aged Mortality Neutropenia Patients Retrospective Studies Stem cells Transplants & implants Vancomycin - therapeutic use Vancomycin Resistance - drug effects vancomycin-resistant enterococci VRE
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