Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6

Abstract It has been suggested that ETV6 serves as a tumor suppressor; however, its molecular regulation and cellular functions remain unclear. We used prostate cancer as a model system and demonstrated a molecular mechanism in which ETV6 can be regulated by epidermal growth factor receptor (EGFR) s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2017-01, Vol.384, p.1-8
Hauptverfasser:	Tsai, Yuan-Chin, Chen, Wei-Yu, Siu, Man Kit, Tsai, Hong-Yuan, Yin, Juan Juan, Huang, Jiaoti, Liu, Yen-Nien, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Bone metastasis Bone Neoplasms - enzymology Bone Neoplasms - genetics Bone Neoplasms - secondary Cell Line, Tumor Cell Movement Cell Proliferation Disease Progression Down-Regulation Epidermal growth factor Epidermal growth factor receptor (EGFR) ErbB Receptors - genetics ErbB Receptors - metabolism ETS Translocation Variant 6 Protein ETV6 Experiments Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Male Metastasis Mice, Nude microRNA (miR)-96 MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Mutation Promoter Regions, Genetic Prostate cancer Prostatic Neoplasms - enzymology Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ets - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Review boards RNA Interference RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Studies Time Factors Transcription, Genetic Transfection Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!