Early blood pressure lowering in patients with intracerebral haemorrhage and prior use of antithrombotic agents: pooled analysis of the INTERACT studies

ObjectiveAntithrombotic agents increase risks of intracerebral haemorrhage (ICH) and associated adverse outcomes. We determined differential effects of early blood pressure (BP) lowering in patients with/without antithrombotic-associated ICH in the Intensive Blood Pressure Reduction in Acute Cerebra...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2016-12, Vol.87 (12), p.1330-1335
Hauptverfasser:	Song, Lili, Sandset, Else Charlotte, Arima, Hisatomi, Heeley, Emma, Delcourt, Candice, Chen, Guofeng, Yang, Jie, Wu, Guojun, Wang, Xia, Lavados, Pablo M, Huang, Yining, Stapf, Christian, Wang, Jiguang, Robinson, Thompson G, Chalmers, John, Lindley, Richard I, Anderson, Craig S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Aged Aged, 80 and over Analysis of covariance Anticoagulants Antihypertensive Agents - therapeutic use Antihypertensives Blood pressure Blood Pressure - drug effects Cerebral Hemorrhage - chemically induced Cerebral Hemorrhage - mortality Diabetes Disability Evaluation Double-Blind Method Early Medical Intervention Female Fibrinolytic Agents - adverse effects Hemorrhage Humans Hypertension Hypertension - complications Hypertension - drug therapy Hypertension - mortality Ischemia Lipids Male Medical imaging Middle Aged Patients Pharmacists Preoperative Care Prospective Studies Regression analysis Risk Statistical analysis Statistics as Topic Stroke
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Zusammenfassung:	ObjectiveAntithrombotic agents increase risks of intracerebral haemorrhage (ICH) and associated adverse outcomes. We determined differential effects of early blood pressure (BP) lowering in patients with/without antithrombotic-associated ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT1 and 2).DesignPost hoc pooled analyses of the INTERACT studies—international, multicentre, prospective, open, blinded end point trials of patients with ICH (
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp-2016-313246