Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

The tumor genomic copy number profile is of prognostic significance in neuroblastoma patients. We have studied the genomic copy number profile of cell-free DNA (cfDNA) and compared this with primary tumor arrayCGH (aCGH) at diagnosis. In 70 patients, cfDNA genomic copy number profiling was performed...

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Veröffentlicht in:	Clinical cancer research 2016-11, Vol.22 (22), p.5564-5573
Hauptverfasser:	Chicard, Mathieu, Boyault, Sandrine, Colmet Daage, Leo, Richer, Wilfrid, Gentien, David, Pierron, Gaelle, Lapouble, Eve, Bellini, Angela, Clement, Nathalie, Iacono, Isabelle, Bréjon, Stéphanie, Carrere, Marjorie, Reyes, Cécile, Hocking, Toby, Bernard, Virginie, Peuchmaur, Michel, Corradini, Nadège, Faure-Conter, Cécile, Coze, Carole, Plantaz, Dominique, Defachelles, Anne Sophie, Thebaud, Estelle, Gambart, Marion, Millot, Frédéric, Valteau-Couanet, Dominique, Michon, Jean, Puisieux, Alain, Delattre, Olivier, Combaret, Valérie, Schleiermacher, Gudrun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Child Child, Preschool Chromosome Aberrations Circulating Tumor DNA - genetics Comparative Genomic Hybridization - methods Female Gene Amplification - genetics Gene Dosage - genetics Genomics - methods Humans Infant Male Neuroblastoma - blood Neuroblastoma - genetics Oligonucleotide Array Sequence Analysis - methods Prognosis Prospective Studies
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